In the below referenced study subjects on 100 mg T subq had on average peak levels of 1100 ng/dl. Its reasonable to deduce from this medical study that 138mg subq plus 3x 400 IU hCG will result in supraphysiological T levels.
@dextermorgan how much do you inject to get to almost 2000 ng/dl?
200mg gets me 2000 but 100mg gets me 600. How many folks here take 100mg and have 1000 T levels?
Most of the guys I know on 200mg are around the 1000 total T level.
2000 peak or trough?
I inject daily so that’s 24 hrs after injecting 28.6mg. That was on sub-q
so that makes it average. The linked study reported that on 100mg subq average T was 890 ng/dl (table 2). Which means the level eg you achieve is in perfect alignment to the article.
i don’t think the HCG will be doing much for me since I’m primary hypogonadal
what sides should I be watching out for? for too high Test I’m guessing acne, aggression, high bp, for too high E I’m guessing nipple sensitivity, ED, mood swings, anything I’m missing?
What does that have to do with telling someone their protocol (which they are under a competent doc’s supervision) is too much and will likely experience E2 side-effects when you have zero info of how it will effect them? I say that because the same shit happened to me and I attributed all kinds of shit to high E2 when it was all in my head. That caused me to have a miserable first 6 months on TRT. Look at all the posts attributing every little thing to estrogen.
If you want to be miserable then start looking for sides before they present themselves. You’re going to be fine. Expect 6 weeks of your body adjusting before you really start to feel the TRT positives.
yeah I’m not looking to be a hypochondriac, just want to know if there are any real red flags. I know the first weeks are going to be wild anyway with my body figuring out what it wants to do. I’m curious because the doc gave me the anastrozole to take as needed, they seem to think I will probably need some AI due to my high E2 sensitivity test
You’ll feel a lot better if you don’t take it especially the first 6 weeks. If life becomes unbearable then post here and people can guide you on whether it’s something to take an AI for. I attributed all kinds of things to high E2 and end up crashing it several times. Crashing is the most miserable experience I had on TRT and there’s no quick fix.
I would think Defy gave it to you so you would have it on hand if they decide you need it. As in you let them know what’s going on and they say take it or don’t. I doubt it’s there for you to take when you want.
Stay on the protocol, @dextermorgan has also a good point.
When you go overboard with E2 just remember to maybe lower the dose before taking the AI. Bloodwork can be done already after 3 to 4 weeks. Nothing dramatic will happen past the 4 weeks mark regarding T and E2 levels as you reached steady state.
Good luck!
no originally they wanted me on it along with everything and walked it back to as needed after i expressed concern about the sides, and they also wanted to start me on a slightly higher dose
I’m low 800’s at trough, ,on 15 mg a week,split into 2 injections. 100 mg is pissing in the ocean for some of us.
Serum levels on subq seems to be 20 to 25% higher then im. So your 75mg 2x week (i guess im?) translates to about 2x60 mg subq. Typically once weekly is associated with a difference between peak and trough of 350 ng/dl at 120mg per week. Splitting it makes the delta go to about 170. So with a trough of low 800, it makes a peak of around 1000, average of 900.
So the article says average of 900 at 100 mg subq and you achieve about 900 at 120 subq. Thats also in perfect akignment considering the intersubject variability.
Guys we simulate PK profils of molecules like filgrastim with multiple clearance pathways and many factors to consider in a 2 or 3 compartment model. PK of T is not really rocket science.
That was Sub-q ,I recently went to shallow IM because I was getting too much bruising with Sub-Q. It is really hard to pigeon hole dosing, there is tremendous diversity in individuals. The once a week numbers were not terribly different.
is there a real difference between being at top of range and supraphisiological if its only by 50 points? or is it some sort of threshold?
Ok test/hcg arriving wednesday, can anyone tell me if im missing anything?
Luer lock syringes
29ga 1/2" needles
alcohol wipes
sharps container
You should be using insulin syringes, Luer lock syringes have a dead space where medicine is wasted which may not be a problem if injecting 1-2x weekly, but if you start injecting daily or EOD then you may run out of medicine before your refill.
I have never seen a Luer lock syringe that didn’t have a dead space.