Gotta agree there!
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Are you 6â 3â with the biggest hands also?
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Iâm on Nebido (injected every 10 weeks), anything in your knowledge bank thatâd explain a crash 6-8 weeks after an injection, a slight return to feeling better before the next injection and joint pains starting 4 weeks after an injection? My muscles also feel very âtightâ. I donât have flexibility issues otherwise, and the tightness feeling persists even when warmed up good and proper.
If thereâs a mechanism that explains this, itâd be nice if I could highlight it to my doctors. Finally got remitted from my urologist to an endocrinologist, but have yet to meet with them.
My guess is that my cortisol receptors are drowned in androgens for a while, and then as the blood concentration levels of T diminish Iâm dealing with a backlog of stress hormones explaining the mental crash but I donât know what to think of the joint pain.
Joint pain is usually tied to low E2. Could be other things, but thereâs a good chance your levels tun down just before the next shot.
The AI demonstrated a benefit to these patients where serum T was significantly improved as well as sperm production.
Needless to say, thatâs probably where the benefits end. At that point, there is no mention of what the cons would have been. We know that AIs are toxic. Damage to the endothelial, and etc. etc. etc. etc.
Itâs great to point out the benefits of something but without also discussing the downsides, whatâs the point? This would be the equivalent to me saying, âWhen I shoot up with heroin I feel SO GOODâ. Therefore, benefits are demonstrated with heroin use. MeanwhileâŠ
This is the way I see things. I need an unbiased demonstration of both pros and cons. Having higher levels of T, for example, for the list of PROS I could make a list as long as this thread lol. The cons? It âmightâ cause issues down the road which remain to be seen which âmayâ affect some but not others. If the pros vastly outweigh the cons, thatâs good enough for me. Most medications out there have a list of cons that are two pages long, which you hope not to get as long as you get the one pro that itâs been designed to do.
This is why I donât understand all the fuss about running levels that todayâs society deem to be slightly âtoo highâ based on the current state of the population. It doesnât make sense to me at all.
Yep
Could the same outcome potentially have been achieved using HCG monotherapy with less downsides being a benefit over letrozole?
I got a quick reply from one physician:
This is not news to âAerospace Physiologistâsâ; Very high Hgb has always been a RF; much more so than elevated Hct.
Totally makes sense, one of the reasons nebido is a terrible choice.
Just try to get any other ester from pharmacy will be much better
Itâs either that or gels here and I have allergic skin reactions to all of them 
You appear to be correct⊠now Iâll have to ask him to clarify lol! Iâll get back to you.
I totally forgot that it was discussed on the YouTube channel. Not a physician but has clinical experience. You can have a look and tell me what you think.
The statements in this video are irrelevant to the finding that Hb and HCT communicate the same clinical information, i.e., the volume of RBCs in relation to total whole blood volume.
I just watched it⊠and, yup, correct⊠it wasnât discussed. Sorry about that!
Correct⊠not same gentleman⊠It had just dawned on me that the topic of hematocrit was once discussed so thought Iâd share it if you found anything relevant within the video. I will share your feedback with him.
I need to make it clear, which youâve probably already figured out on your own, that I am completely out of my element in this particular area. I still have a TON of stuff to learn.
Try injecting it once per week
Iâm so sorry I missed this one. Nebido is a terrible way to do TRT. You wind up with a big peak and then a slow and steady decline over a two month period. Your body never finds any type of homeostasis and is constantly in flux. You need to be using something where you can be injecting more frequently⊠at the bare minimum once weekly.
Where are you located where you can only get nebido?
I remember my cardiologist telling me he gets concerned when hgb goes above range.
Didnât ask why as mine was in range
@readalot I got another reply for you. Physician who prefers to remain anonymous for now:
So this is actually a really good thread and the poster makes good points. I actually thought Justin Saya had the best post.
My issues are with the presuppositions of higher HCT = âthicker bloodâ in the sense they are saying.
They are not directly measuring viscosity in these studies but using surrogates. There could be many contributing factors to flow mediated dilation.
This is where real
Science would have to come in. Might be hard to have HCT as an independent variable but itâs needed.
The Andean study isnât necessarily relevant. Itâs one group with specific issues.
We need studies on men on TRT.
I get people being cautious. I do. There is no black and white for this HCT thing.
Iâll try and dig deeper into the studies he posted and read the full papers, and dig in to these measures of âviscosityâ and shear stress, etc, before making any real comments.
I simply see a LOT of assumptions and confounders with these papers and those things need teasing out.
Iâll dig further.
Iâm still on the fence on this issue. I just want accurate measures and to know if theyâre even relevant. We can assume a lot from these measurements that may have zero clinical significance.
Sweden, weâre not allowed to self-inject either so canât take from a vial every week either. Just want to know more about how bad it is and what the fluctuations might do to make it easier for me to have a conversation with the doctors.
Gels are prescribed too but I get allergic skin reactions to all of them and am very concerned about how much of it gets spread around (people/pets).