Something Wicked This Way Comes... Again

[quote]Bill Roberts wrote:
Well, the statement was surely not backed by evidence. Let’s leave it at that.

I actually do think it’s possible that Androsol was related to your banging the Playmate. It’s totally unproven and we never made a point of it, if even mentioned it all at any time (I can’t guarantee I might not have mentioned it in the forum as personal experience) but I know quite a few including myself that very, very strongly suspect from personal experience that Androsol had a very, very significant pheromone-like effect on women.

Sadly, the chance of 11-T replicating that is essentially zero.

[/quote]

That and the fact that I maintained an 8%BF at 200lbs very easily on andrsol made it easy also!

TO the guy that thinks transdermal delivery is worthless is a FOOL. (and must of never tried androsol) ,ANDROSOL was the bomb, and worked perfectly, and even better than I ever thought. I actually preferred androsol OVER MAG-10 IMO. I never tried the MAG-10 in pill form only the LIQUID though.

I commend you Bill Roberts for pushing the envolop on this one!

[quote]HD8 wrote:
IF using one application per day wouldn’t you preferentially want to apply the 11-T in the afternoon or night when we want cortisol to be lower not in the morning when we want it to be higher?[/quote]

If there were no intent of avoiding LH inhibition and thus allowing longer use, then I would use at half dose 2x/day rather than full dose 1x/day. Just as you suggest.

On the timing you suggest, hypothesizing that there would be an advantage to higher levels at night, that sounds logical and entirely reasonable, and I don’t have direct observations or literature evidence to say no.

But personally I believe no, from what a Greek (that is to say, he lives in Greece) doctor advised me from his findings in use of Cytadren as an anti-aromatase. He found it beneficial to avoid cortisol inhibition at night, but to allow some of it during the day, rather than the other way around. His reason for saying this was from observed outcomes, but he also suggested a theory that cortisol rise in the final hours of sleeping is part of the natural process and interfering with it causes more problems than reducing daytime stress-caused cortisol increases, which aren’t required and so partially inhibiting that is not a problem.

Not the exact same thing is happening here, as systemic levels of cortisol will not be affected, only local conversion of cortisone to cortisol, but the same principle may apply.

As personally how I weigh evidence, I never found this doctor to be wrong on anything he ever advised or reported to me, so personally, not knowing the outcome on something and not having direct evidence, I would put my money on his being correct.

[quote]Last question,finally if taking only one dose(35sprays)wouldn’t it be better to take half 17 sprays in the morning and 18 sprays at night,assuming timing is no issue?
Thanks in advance[/quote]

Sure thing!

Yes, I believe it would.

[quote]MISCONCEPTION wrote:
TO the guy that thinks transdermal delivery is worthless is a FOOL. (and must of never tried androsol) ,ANDROSOL was the bomb, and worked perfectly, and even better than I ever thought. I actually preferred androsol OVER MAG-10 IMO. I never tried the MAG-10 in pill form only the LIQUID though.

I commend you Bill Roberts for pushing the envolop on this one! [/quote]

Thank you! But to be clear and not take undeserved credit, while I developed the delivery system it is Patrick Arnold who is to thank for bringing adrenosterone and then 17b-hydroxyadrenosterone (also called 11-KT) to market, and Tim Patterson that was really responsible for using our transdermal technology on this product.

I consulted on it and contributed a couple of aspects (the new-to-the-non-pharmaceutical-industries penetration enhancer that this has, and I think the fact that it is an acetate though I’m sure Patrick would have advised the same for our application, and for what it’s worth which is nothing I did some early work trying to make a better-than-capsules liquid version of it that didn’t pan out) but it is really Tim and Patrick who pushed the envelope on this.

Well, now that you mention this pheromone like effect of Androsol… if I were to have some Androsol that had been kept in a cool, dark place for the last 8 years or so (but not frozen)… any chance that pheromone like effect might still kick in?

I’m desperate, here.

[quote]nephorm wrote:
Well, now that you mention this pheromone like effect of Androsol… if I were to have some Androsol that had been kept in a cool, dark place for the last 8 years or so (but not frozen)… any chance that pheromone like effect might still kick in?

I’m desperate, here.[/quote]

I would think so. The only reason I wonder is that Steve McGregor said he had found some instability but I am not sure that what he saw may not have been an artifact of GC/MS. (I just don’t know.)

I wouldn’t think from the structure it would be unstable in isopropyl alcohol in a cool dark place, even after 8 years. I could be wrong, but I wouldn’t think it unstable.

“Like I said, one bottle of 11-T�?� costs $124.95 and will last approximately three weeks, at maximum application.”

I just want to confirm that the max dose is 35 sprays twice a day for a total of 70 sprays a day. So 11-T will last 3 weeks at 70 sprays a day?? Is that correct?

Bill where would one get a salivary testosterone test?

Anyone else notice that Bill’s only a level 2. Guess he’s gonna have to buy a couple more bottles of 11-T!

Great stuff Bill. I love the fact that I really have to READ your posts (sometimes twice) to retain all the information. Thanks and I have 2 bottles on the way!

[quote]DSQ98 wrote:

Anyone else notice that Bill’s only a level 2. Guess he’s gonna have to buy a couple more bottles of 11-T![/quote]

Ha! That system is currently being rebuilt. Sometimes it’s a little slow to the punch (regenerating).

[quote]DSQ98 wrote:
“Like I said, one bottle of 11-T�?� costs $124.95 and will last approximately three weeks, at maximum application.”

I just want to confirm that the max dose is 35 sprays twice a day for a total of 70 sprays a day. So 11-T will last 3 weeks at 70 sprays a day?? Is that correct?[/quote]

Yes.

It may even go a little longer, potentially 24 days worth.

I have used ZRT, but going to their webpage now to check it, I was seeing very high prices for tests more comprehensive than necessary.

Googling yielded Saliva Hormone Testing - Perimenopause, Menopause and Andropause which uses ZRT but offers a plain ol’ testosterone test for $30. Maybe that is on ZRT’s own website and I missed it, I dunno. But anyway that’s the sort of price one ought to be paying for a single hormone test.

The level depends on store purchases? (I don’t know.)

I’m surprised I’m even a level 2 then, because Tim is kind enough to allow me Biotest products for free. I’ve chosen to purchase books and videos though, because I don’t want to stiff the authors out of their royalties.

[quote]
Great stuff Bill. I love the fact that I really have to READ your posts (sometimes twice) to retain all the information. [/quote]

Thanks! Glad that it is of help!

[quote]LowfatMatt wrote:
DSQ98 wrote:

Anyone else notice that Bill’s only a level 2. Guess he’s gonna have to buy a couple more bottles of 11-T!

Ha! That system is currently being rebuilt. Sometimes it’s a little slow to the punch (regenerating).[/quote]

Also for some reason my join date and post count must be altered from some massive data loss. I was posting long before 2003 – maybe something like 1999? – and I thought I had at least a couple thousand posts.

Hey Bill, I got a question, I read your early regarding 11-T and V-Diet. Lil bit about me, former fat boy, from 310 to 215 now. Im 22 bout 6’1 low teens for BF%. Unless Im ultra strict in my diet, I tend to have the typical trouble areas that someone with my weight loss would have, love handles arent so bad, but I got a good amount of lower back fat that I cant seem to shake and although its not perfect I do consider myself extremely lucky in terms of loose skin for the amount of weight I’ve lost.

Now heres the Q.

Id I did the V-Diet, would it be beneficial/ worth while to apply the 11-T to strictly the trouble areas as in lower abs, oblique, and lower back in an attempt to really hit them. or would you suggest complete application?

Thanks for any help you have to offer…

Bill,

You are a gentleman. It is an absolute pleasure to read your responses.Very informative.

Thanks,

Marc

[quote]Bill Roberts wrote:

Also for some reason my join date and post count must be altered from some massive data loss. I was posting long before 2003 – maybe something like 1999? – and I thought I had at least a couple thousand posts.
[/quote]

Yeah, I noticed the same thing regarding join dates. If i remember correctly, T-Nation revamped their dbase around that time. I think that some people even had their screen names tweaked.

Anywho, should one anticipate any strength gains outside what would be expected from typical glycogen weight gain? I realize that this product will do more then water gain, but just wondering if more then trivial strength increase can be expected?

BTW, I LOVED Androsol! I never got the effect from oral 4-AD-EC that Adrosol gave me. From a biz/marketing strategy, I realize WHY u went away from the transdermal; BUT, man was I sad. : )…No question that it put a cave man spell on the women…funny. They even asked to have their hair pulled

[quote]Bill Roberts wrote:
I would think so. The only reason I wonder is that Steve McGregor said he had found some instability but I am not sure that what he saw may not have been an artifact of GC/MS. (I just don’t know.)

I wouldn’t think from the structure it would be unstable in isopropyl alcohol in a cool dark place, even after 8 years. I could be wrong, but I wouldn’t think so.
[/quote]

Oh, wow, thanks. I’ll give it a shot.

[quote]HateMachine wrote:
Id I did the V-Diet, would it be beneficial/ worth while to apply the 11-T to strictly the trouble areas as in lower abs, oblique, and lower back in an attempt to really hit them. or would you suggest complete application?

Thanks for any help you have to offer…[/quote]

Glad to!

I would apply to those areas but not any more heavily than overall. I would still take up about half the total available area, that total area being however many square feet the torso, arms, and legs are.

You could certainly choose to omit whatever half of the total has least need of local fat loss.

I wouldn’t assume that heavier application would result in more compound going through that area of the skin. The skin, so to speak, does not “know” how much material is on top of it, and the molecules of compound slowly diffusing their way through the skin don’t “know” either how much there is behind them. The exception is if material actually starts running out, but with normal application that won’t happen for many hours.

So thicker coat (past the recommended light point) isn’t better, but larger area is better.

Thank you, Marc!

Gnostic, yes, I’d certainly, with suitable nutrition and training, expect to see some strength gains. For an experienced trainer that might well be just something on the order of getting an extra rep after two weeks, and being able to keep it afterwards, at a time when reps just weren’t getting added otherwise; or several percent more weight for same reps, etc.

Sometimes an experienced and generally plateau’d weight trainer experiences from a performance enhancer gains that are kind of disproportionate. For example, gaining 2% per week half the weeks per year would be a phenomenal rate of improvement for an advanced trainer. How many guys who, for their natural gifts, are doing really well to be benching say 365 and took many years to accomplish this and they’ve trained intelligently but nonetheless the last few years have seen little to no improvement… how many of these guys are really going to be benching 52% more or 555 lb a year later?

Maybe if the difference is training with Louie Simmons they will, but ordinarily not even high dose anabolic steroids would give that.

So “even” 2% per week is actually a very fast rate of strength increase for an advanced lifter.

But it does happen that someone will far surpass this and be benching 40 or 50 lb heavier in a short period of time. Sometimes one does hit the jackpot.

My point is, if ordinarily there would have been no strength increase – and that IS ordinarily the case with advanced lifters as even a 1% per week average would give them 52% per year and obviously that is not happening for them – then being say 5% stronger after 2 weeks of a supplement while mahy would think “that’s nothing” it’s actually a very decent outcome if it occurs.

On the glycogen: There might be strength gains from increase in glycogen but if so it is too subtle for me to notice. There is an increase in work capacity in long workouts from it though.

[quote]Bill Roberts wrote:
HateMachine wrote:
Id I did the V-Diet, would it be beneficial/ worth while to apply the 11-T to strictly the trouble areas as in lower abs, oblique, and lower back in an attempt to really hit them. or would you suggest complete application?

Thanks for any help you have to offer…

Glad to!

I would apply to those areas but not any more heavily than overall. I would still take up about half the total available area, that total area being however many square feet the torso, arms, and legs are.

You could certainly choose to omit whatever half of the total has least need of local fat loss.

I wouldn’t assume that heavier application would result in more compound going through that area of the skin. The skin, so to speak, does not “know” how much material is on top of it, and the molecules of compound slowly diffusing their way through the skin don’t “know” either how much there is behind them. The exception is if material actually starts running out, but with normal application that won’t happen for many hours.

So thicker coat (past the recommended light point) isn’t better, but larger area is better.[/quote]

I thought one would want to avoid spraying fatty troublesome areas?

[quote]Bill Roberts wrote:
NateOrade wrote:
I ordered 2 bottles.

So as far as training and nutrition goes:

If one is looking to put on muscle, just keep eating a lot and kicking ass in the gym while using this stuff?
Pretty much, though some things are probably optimized a little differently:

  1. Fats, other than EFA’s and oleic acid (which might be called semi-essential) are probably better substituted with carbs or, if protein isn’t high, protein.

In contrast, without any hormonal supplementation it’s best not to drop fat intake to too low a percentage of total calories – the optimum is probably 30-40% then.

But with the assistance, each unnecessary gram of fat is roughly 2 grams of carbs, 2 grams of protein, or some mix of the two that has to be omitted; or it’s an extra gram of fat being added to the fat stores if the carbs or protein are being added anyway along with the fat.

  1. This isn’t different from when there’s no hormonal assistance, but the heaviest carb consumption is best from pre- and post-workout shakes and the meal or two following the workout, rather than getting the carbs equally across the clock or mostly at different times than that.

On non-workout days, daytime is probably best – again, same as usual on this one, but it’s a point not everyone follows.

  1. Times where gains are really likely are not the time for weird-ass exercises, but for the fundamental and old-reliable, both for the individual lifter and in general, exercises.

There’s a reason many professional coaches want you to for just the next two weeks or other brief time, do one arm dumbbell bench presses off a Swiss ball (or other weird exercise) and then quickly change to another, then yet another, etc etc etc.

The reason is that if you charged hundreds or thousands of dollars per hour, would your client be happy with being “only” 2 percent stronger after say four weeks of paying at this rate for you?

No! (Though in fact, for example a 500 lb competitive bench presser, who has been at this level for a few years, going to 550 in 20 weeks would be a superb training outcome.)

No, the client wants to see 10% (or some other large number) improvement every week! Now he is getting his money’s worth.

Of course this WILL NOT HAPPEN in a program sticking with the fundamentals and using them as the reference and assuming it’s an experienced athlete, but it sure as heck will happen when the first performance is totally compromised by how weird and unfamiliar the exercise is, the second is improved by some learning at it, and the third is starting to really get the hang of it.

Time for the next weird exercise so as to gain 10% every week, but somehow certainly not 520% by the end of the year and not “even” 52%!

So don’t fall into that trap regardless of how many training articles advise it. Bring up the major lifts. Assistance exercises addressing specific individual weak points are also appropriate, but not as the majority of sets done.

  1. It’s not a time for HIT-jedi style training, at least not if done the same way one is used to doing it. It could be acceptable if desired to do an unfamiliar intensifying modification, such as for example, not simply one set of each exercise.

But using for example Dante’s “DC-style” training where after doing as many reps as can be done with hardest work but still correct form, rest (for example) 10 real seconds and then do as many more as possible.

Then rest 15 real seconds and again do as many as possible, this time (if the contracted position is under tension) holding the final contraction for a good period of time such as 10-20 seconds or the maximum possible, and the final lowering as slowly as possible.

Not that it’s necessary to use this method, by no means, but it’s an example of how if you like HIT, it can be intensified into something appropriately useful if not doing this method already. If you are already totally acclimated to this specific method, then it would probably be better to find something else.

Of course, I don’t mean to suggest that training need or ought to be similar to HIT-jedi anyway. That is only IF one is most comfortable with that philosophy and inexperienced with anything else and fearful that going too different could flop.

  1. Training volume. Probably it profitably can be higher than usual, but not to a ridiculous level.

By the way, even if believing in low volume, if one accepts Arthur Jones as an authority, he had his greatest success as a trainer and wrote his Training Bulletins on the principle of 72 sets a week.

This still remains a valid approximate total amount, whether hormonally assisted or not, though if not it can be at the high end and if so, it can be a little low.

  1. If you have a long term cyclical training plan, of course the best time would be during those weeks where gains can most reasonably be expected.

For example, when I was using a Scott Warman-type powerlifting program – week 1 starts with weights slightly higher than could be and were done last cycle for say 9 reps, the final week is set to be a weight slightly higher than could be and was done for a triple last cycle, and the intermediate weeks have equally-spaced weight increases that should yield drops of exactly 1 rep each week thus terminating in the final-week new-PR triples – my best chance of muscle gain was in the 5-6 rep range, so I targeted androgen use for then. Others might personally do better at different times or with different programs. This is just an example.

But the point is, use at what is the most likely time for success within the training program, which is not every single week – for a more advanced lifter, if it seems that all weeks are equally likely then the training program ought to be rethunk. (For a more novice lifter, it’s okay to have each gain about equally likely for gains.)[/quote]

Holy crap - thanks!

Hell yeah.

“Maximal effectiveness of 11-T�?� is reached with a light, thin coat sprayed evenly over freshly showered �?? but absolutely dry �?? thighs, torso, and arms. The key is not to concentrate extra spraying over your problem-fat areas.”

Thats from the article…now i’m confused. Should we spray the troublesome areas or not

Oh and how long would this still be in our system after discontinued use? JW

[quote]DSQ98 wrote:

Anyone else notice that Bill’s only a level 2. Guess he’s gonna have to buy a couple more bottles of 11-T!
LowfatMatt wrote:

Ha! That system is currently being rebuilt. Sometimes it’s a little slow to the punch (regenerating).[/quote]

He has to pay? He should get his shit free. Ain’t that a perk for working here? Maybe a discount? Doesn’t he grab a bottle of something or other on the way out of the lab every day?

Tim, you gotta give your guys those perks, otherwise they steal office equipment. Bill probably has 43 staplers, a couple of office chairs, a flat screen monitor, and that secretary that’s been missing for 2 months.