SHBG upregulation
Does an increase of free testosterone causes an SHBG upregulation as an homeostatic response?
If one subject genetically has high SHBG that will led him to have low free testosterone. This will be his homeostatic set point.
Then this subject decides to go into TRT or blasting. At first there’s a honeymoon period when the effects of extra testosterone are notable. Then things feel the same as they were at the start.
Most steroid users have reported a loss of effects after some time (hence the Androgen Receptor down regulation theory).
Also Proviron users report a honeymoon period that fades as time goes, given that mesterolone binds to SHBG the body tends to produce more of it to restore its own free test balance.
Is it possible that the improvements that TRT guys need rely on an increase in free test (which they were deficient), but this improvement fades as the body increases SHBG production in an homeostatic quest?