[quote]TxCASH wrote:
Maybe someone can help me out here. I’m on antidepressants. 150mg wellbutrin and 10mg paxil per day, both of those being pretty much the lowest prescribed doses. The depression is pretty much under control but unfortunately I’m having some sexual side effects (ie. very low sex drive). From what I’ve read, antidepressants can raise prolactin. So maybe that is part of the problem?
The real question is if I’m already on an SSRI (paxil), would it be safe to take selegiline at a very low dose alongside the paxil in hopes that I’d get a boost to my sex drive? I’m not afraid to ditch the paxil if that is necessary however.
[/quote]
First of all, thats great that you’re experiencing successful treatment of your depression, as it can be a hell of an animal to tame. Be aware that Paxil has a reputation as being one of the harshest of the SSRIs with regard to sexual side effects. It also is notorious for promoting weight gain. Since you are having success with the Welbutrin/SSRI combo, I think the first logical step would be to switch to a different SSRI such as Prozac, Zoloft, or Lexapro. Personally I would lean towards the Prozac as it’s the “old faithful” among SSRIs and it tends to be less sedating than Lexapro and less likely to cause GI distress than Zoloft. Paxil is known to have an unpleasant discontinuation syndrome but that would be somewhat mitigated by the substitution of a different SSRI.
If you continue to have sexual side effects, it would make sense to increase your Welbutrin dosage. As you stated, you are on a low dose of Welbutrin. It acts partially as a dopamine reuptake inhibitor so some people find that it boosts libido. From personal experience I did not necessarilly find Welbutrin to boost my libido but it did make sex slightly more pleasurable (which I didn’t think was possible) and orgasms more intense.
[quote]TxCASH wrote:
Maybe someone can help me out here. I’m on antidepressants. 150mg wellbutrin and 10mg paxil per day, both of those being pretty much the lowest prescribed doses. The depression is pretty much under control but unfortunately I’m having some sexual side effects (ie. very low sex drive). From what I’ve read, antidepressants can raise prolactin. So maybe that is part of the problem?
The real question is if I’m already on an SSRI (paxil), would it be safe to take selegiline at a very low dose alongside the paxil in hopes that I’d get a boost to my sex drive? I’m not afraid to ditch the paxil if that is necessary however.
[/quote]
First of all, thats great that you’re experiencing successful treatment of your depression, as it can be a hell of an animal to tame. Be aware that Paxil has a reputation as being one of the harshest of the SSRIs with regard to sexual side effects. It also is notorious for promoting weight gain. Since you are having success with the Welbutrin/SSRI combo, I think the first logical step would be to switch to a different SSRI such as Prozac, Zoloft, or Lexapro. Personally I would lean towards the Prozac as it’s the “old faithful” among SSRIs and it tends to be less sedating than Lexapro and less likely to cause GI distress than Zoloft. Paxil is known to have an unpleasant discontinuation syndrome but that would be somewhat mitigated by the substitution of a different SSRI.
If you continue to have sexual side effects, it would make sense to increase your Welbutrin dosage. As you stated, you are on a low dose of Welbutrin. It acts partially as a dopamine reuptake inhibitor so some people find that it boosts libido. From personal experience I did not necessarilly find Welbutrin to boost my libido but it did make sex slightly more pleasurable (which I didn’t think was possible) and orgasms more intense.[/quote]
Sorry for hijacking the thread.
My girlfriend is on paxil and has a great sex drive. But as I’ve heard so many times, everyone reacts differently to different drugs. I’m gonna call my doctor and see if I can switch out the paxil for something else. Hopefully without crashing too hard. Correction: I am actually on 300mg welbutrin… my mistake. It’s such a pain in the ass having depression. Thanks for the response
Yeah, I know…it’s an older thread. Not specifically trying to bump it, just reporting on my personal experience with the substances mentioned.
I’ve been using deprenyl for five weeks now, and it’s effect is pretty much as-described by Bushy and KSman. I front-loaded 5mg/day the first two days (in retrospect probably unnecessary), then went to 2.5mg EOD. It’s important to note that it took about about ten days for me to notice any real effect. I suspect that several of those who posted that they were disappointed with deprenyl likely didn’t give the drug sufficient time to begin providing benefits. As my dopamine level started to increase I could definitely feel very significant positive changes in both my libido and overall mood. The fact that my GF commented multiple times on both tells me that there is more than just “placebo effect” going on here.
Three weeks in, I increased the dosage to 2.5mg ED, and the effect went from noticeable/significant to utterly profound. I’m in my early 50’s now, and even 18 was nothing like this. The neat thing about this compared to say…two weeks into a test/tren cycle…is that it doesn’t adversely affect other parts of my life; in some ways I’m even calmer than usual. I can still concentrate at work, I’m not distracted by every attractive woman that walks by, etc., just feel an incredibly strong drive towards the end of the day to get home and begin heaping lavish amounts of attention on my lady in various ways…attention that I know will be returned many fold. At the moment I have no plans to experiment with another dosage increase, as I am extremely happy with my sex drive at this point.
KSman and a few others mentioned complimenting deprenyl with small doses of PEA to improve orgasm intensity. This too, works well for me. As KSman alluded, “conventional” dosing of PEA (400-500mg)along with deprenyl is a bit “loud” - 250-300mg is usually perfect for reducing size of my universe down to the room that my GF and I are occupying for a few hours. Orgasms come fast and thick, usually rivaling the “big bang” in intensity. The only thing I’d add here is that it seems to be really important to watch hydration levels when using PEA. My normal resting heart rate is around 55-60, but if I’m even the least bit dehydrated just 200mg of PEA will raise my resting heart rate up into the 120’s. So far though, this hasn’t happened when I’ve paid close attention to fluid intake throughout the day beforehand.
I’ve read that some like to stack deprenyl with cabergoline and I might try that in the future…just not sure how things could get much better than they are right now. Thanks again to Bushy for starting this thread and making me aware of this drug’s potential benefits.
A quick question for KSman, Bushy, or anyone else with knowledge on the subject:
Due to my own positive experience with it, my GF has expressed interest of trying deprenyl, but she’s currently on 10mg/day of Lexapro. From my reading here and at other sites, I understand that the use of deprenyl is contraindicated with most SSRI’s. Is this a dose-specific situation? What alternatives might she have?
I’ve been using Selegiline for a few weeks now, it is a fantastic drug! I have often suffered from seasonal depression, and this year I was determined to beat it. A dose of 2.5mg EOD has already given me a “pleasant lift in daily energy, mood, libido” and I would like to thank BBB and KSMan for the information in this thread.
[quote]last1standing wrote:
A quick question for KSman, Bushy, or anyone else with knowledge on the subject:
Due to my own positive experience with it, my GF has expressed interest of trying deprenyl, but she’s currently on 10mg/day of Lexapro. From my reading here and at other sites, I understand that the use of deprenyl is contraindicated with most SSRI’s. Is this a dose-specific situation? What alternatives might she have? [/quote]
Missed this when I was hospitalized.
The combination might create a overload by further extending the life of neural transmitters. As deprenyl MAO-B action can last for a week, the issue would not be short lived, however, one could back off of the SSRI.
Selegiline has a low oral bioavailability, which increases to moderate when ingested together with a high-fat meal (the molecule being liposoluble).
Selegiline’s oral bioavailability is drastically increased in females taking oral contraceptives (10- to 20-fold).[15] This could lead to loss of MAO-B selectivity in favor of an MAO-A selectivity, which in turn would make patients suspectible to the usual risks of unselective MAOIs such as tyramine-induced hypertensive crisis and serotonin toxicity when combined with serotonergics such as SSRIs.[15]
My experience, also confirmed by a friend, was that the effects of selegiline (even at 5mg/Ed) were so subtle as to be placebo. Maybe it had an effect, maybe it didn’t, but it is really difficult to do a double blind experiment on one’s self. I understand individual reactions are highly variable, and it is relatively inexpensive, so I suppose you should try it for yourself, but I didn’t feel like it lived up to the hype.
That said, I WILL be using it concurrently with my next Tren cycle as an anti-prolactinase, and am guessing it will work fine in that regard
My experience, also confirmed by a friend, was that the effects of selegiline (even at 5mg/Ed) were so subtle as to be placebo. Maybe it had an effect, maybe it didn’t, but it is really difficult to do a double blind experiment on one’s self. I understand individual reactions are highly variable, and it is relatively inexpensive, so I suppose you should try it for yourself, but I didn’t feel like it lived up to the hype.
That said, I WILL be using it concurrently with my next Tren cycle as an anti-prolactinase, and am guessing it will work fine in that regard
An update. I have not been right since my surgical disaster and infection in July. I stopped Wellbutrin two years ago as it was too stimulating for me. This fall I slumped into not being myself and had low energy and initiative. It got worse and I was into a deep apathy depression. Two weeks ago I started 100mg in the AM, then last week 200mg in the AM. I am active and getting things done, more like my old self.
How long will that last? One never knows. I though that it was interesting that a drug that I had trouble tolerating over time two years ago, now it completely different. I guess that is a measure of how damaged I was by the events last summer. Now I need the stimulating effect that was a problem two years ago.
[quote]KSman wrote:
An update. I have not been right since my surgical disaster and infection in July. I stopped Wellbutrin two years ago as it was too stimulating for me. This fall I slumped into not being myself and had low energy and initiative. It got worse and I was into a deep apathy depression. Two weeks ago I started 100mg in the AM, then last week 200mg in the AM. I am active and getting things done, more like my old self.
How long will that last? One never knows. I though that it was interesting that a drug that I had trouble tolerating over time two years ago, now it completely different. I guess that is a measure of how damaged I was by the events last summer. Now I need the stimulating effect that was a problem two years ago.[/quote]
Interesting observation. Best of luck with the recovery.
Ordered some selegiline but totally forgot I can’t use it with my Adderall script. Will take a few months off Adderall after my DNP cycle and see how selegiline affects me. So far Stablon (Tianeptine) has done absolute WONDERS. I abused MDMA in the past and Stablon has returned my mood back to the pre-MDMA days.
“”"
Selegiline is partly metabolized to l-methamphetamine, one of the two enantiomers of methamphetamine in vivo.[18] A characteristic metabolic pattern was noted, exemplified by a ratio of l-methamphetamine to l-amphetamine of about 2.8.[19] This stereoisomer is not considered psychoactive and has little abuse potential.[20]
The stimulatory effect on locomotor activity and dopamine synthesis may be contributed to by the action of l-methamphetamine. If anyone is prescribed and takes selegiline, they can and will test positive for amphetamine/methamphetamine on most drug tests, however the prescription for selegiline would explain why they test positive for amphetamine/methamphetamine.
“”"
“This stereoisomer is not considered psychoactive” not clear what “this” refers to.
I was on low dose deprenyl/seleginine well before resuming Wellbutrin. Can’t attribute current improvements to deprenyl.
m. pruriens: Contains L-dopa. L-dopa has many effects in the body, not including brain, that can be very unpleasant. L-dopa is compounded with other drugs to inhibit L-dopa in the body. So L-dopa is not very useful. You can find L-dopa on the internet if you want to find out for your self. You really need to increase l-dopa in the brain, not the body. So you need to find things that cause more dopamine to be created in the brain and/or find ways to slow down the metabolization of dopamine.
Drugs that jack up dopamine to get high, will cause damage to dopamine systems in the brain.
[quote]T-Matt wrote:
Ordered some selegiline but totally forgot I can’t use it with my Adderall script. Will take a few months off Adderall after my DNP cycle and see how selegiline affects me. So far Stablon (Tianeptine) has done absolute WONDERS. I abused MDMA in the past and Stablon has returned my mood back to the pre-MDMA days.[/quote]
This was a blast from the past! Still doing Rx Deprenyl/selegiline and cabergoline. Not tried PEA for so long I can’t remember. Was doing some Parkinson’s [a frend has it] reading and it appears that Deprenyl+food can have an absorption rate that is 20% with food and 4.4% fasting. Taking deprenyl with food, with some fats would appear to be a critical factor.
A year ago I had a 3 hour hernia surgery to clean up the mess from 2010. I felt fantastic after that. I think that they used Ketamine - Wikipedia as part of the anesthesia. It can work miracles with depression, major recovery in a couple of hours. I stopped Deprenyl and caber a month before the surgery to avoid any possible issues.