Selegiline/Deprenyl

Pharma
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Ropinirole, a d2/d3 agonist can also be used to reduce prolactin in doses as small as .2mg, but a short half life of c. 6 hours makes dosing a pain… and it’s also not as cheap as selegiline.

I tried selegiline a few years ago and found it really improved my short term memory-- i had a job grading multiple choice exams and pre-deprenyl, would look at the answer key, remember 4-6 answers, mark the questions and thrn have to look back at the answer key before going on to mark the next questions. At doses of 2.5-5mg/day I found I could remember 8 or 9 answers at a time.

It is also a neuroprotectant. I was turned on to the stuff after reading a paper in which the rats on selegiline 1) lived longer 2) finished the maze more quickly and 3)had more sex than the rats without it.

I tried a dose of 10 mg per day and after about a week, if i remember correctly, I woke up in the middle of the night hearing voices- just random words and bits of speech, no one telling me I was jesus or should kill my colleagues or anything like that. Did I turn myself into a schizophrenic for a night, lol?

23

[quote]Babo wrote:
Ropinirole, a d2/d3 agonist can also be used to reduce prolactin in doses as small as .2mg, but a short half life of c. 6 hours makes dosing a pain… and it’s also not as cheap as selegiline.

I tried selegiline a few years ago and found it really improved my short term memory-- i had a job grading multiple choice exams and pre-deprenyl, would look at the answer key, remember 4-6 answers, mark the questions and thrn have to look back at the answer key before going on to mark the next questions. At doses of 2.5-5mg/day I found I could remember 8 or 9 answers at a time.

It is also a neuroprotectant. I was turned on to the stuff after reading a paper in which the rats on selegiline 1) lived longer 2) finished the maze more quickly and 3)had more sex than the rats without it.

I tried a dose of 10 mg per day and after about a week, if i remember correctly, I woke up in the middle of the night hearing voices- just random words and bits of speech, no one telling me I was jesus or should kill my colleagues or anything like that. Did I turn myself into a schizophrenic for a night, lol?
[/quote]

yes, excess dopamine has been linked to schizophrenia.

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I guess my previous email didn’t make me sound too bright… I mean who takes drugs without knowing the long term effects? Let me rephrase my question. In my normal blood profiles pre and post cycle- I have never asked for prolactin levels. My last bloodtest post cycle showed a total T level of over 2,000- my doc almost crapped himself.

Anyway taking Clomid and Nolvadex kept my E levels in check (just slightly high)- so I thought I was ok… Although some weird shit started happening in the bedroom which started to freak me out. Taking this stuff seams to have reversed the ‘weird shit’. So although I don’t have any documented proof my prolactin was out of wack (will ask if I can get that from now on) I am hoping that was the case and the selegiline straightened me out. So here are the REAL questions if indeed I had a shitload of prolactin.

  1. This has never been an issue over the past 10 years of on and off steroid use. Was it the combo of stuff I took this summer or maybe my advancing age contributing to this?
  2. So I take this drug and I feel great. If I ween myself off- will my symptoms return? ie will my prolactin levels increase on their own without introducing juice to the mix? Or should I be ok until I start up again in March?
    Crazy about the hearing voices side effect!

Also I’ve been reading some articles and due to the half life this stuff lives in your brain you could probably do 2.5mg EOD instead of ED- but to be honest I feel so good right now I like the dosage of ED.

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Thanks Bushi! The problems didn’t start until AFTER my tren usage… I started out with good old enanth and winny and moved along to prop and tren along w/ gh throughout and clen and T3 the last 4 weeks.
I was SHA-Redded this summer. I wish I knew about the selegiline this summer as it could have helped me avoid a couple of embarrasing situations… :slight_smile:
Friggin Tren.
Off the subject- Tren cough- Real side or myth? I don’t think I saw it personally after 4 weeks. But a couple of the peeps have claimed they got it. I had never heard of it before this year.

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Selegiline sounds interesting. Being that it’s an MAOI, albeit a less severe than the earlier ones, I was wondering about the side effects. Did any of those who have used it monitor or alter your diets to avoid tyramine-rich foods?

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It is a selective MAO-B inhibitor in doses of up to 10mg/day, the dose for parkinson’s disease. That is way more than we are talking about here. There really does not seem to be any of the MAO issues in terms of direct side effects with low doses. However, all MAO inhibitor drugs can amplify the effects of some other drugs, which can be good or bad. You need to be doing some homework concerning “drug interactions”.

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For the benefit of those currently using Selegiline as well as those, such as myself, who are considering it for the future it seems it would be useful to compile the various substances that should be avoided or monitored in relation to Selegiline.

From what I’ve read the following should be avoided:

-tricyclic antidepressants
-SSRIs
-opiates (most prescription pain meds, especially Demerol)

I’d be interested to hear of any additions to this list as well as any experiences from those who have used Selegiline in the manner we are discussing who have encountered any drug/food/supplement interactions.

31

I forgot to add sympathomimetics(CNS stimulants) to the list.

Since a major worry with the traditional MAOIs had to do with serotonin syndrome, I wonder if things like 5-HTP should be avoided. And since Selegiline is largely dopaminergic, I wonder if one should take care as far as supplementing with dopamine precursors such as Phenylalanine or Tyrosine.

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The problems can be from drugs becoming more potent as they are not getting metabolized by MAO.

I take deprenyl, trazodone and sometimes very small amounts of Wellbutrin. With dopergenic drugs, you really need to take less. There can be a synergy and you need to factor that in. Take small amounts and see how you react. Note that some drugs will have much longer effects with deprenyl on board. You can feel dopamine overload with an incremental dose and that is your upper limit.

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Will caber cause a positive test?

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[quote]ravekennels wrote:
Will caber cause a positive test?[/quote]

Err, for amphetamines? It has a very different structure so I’m going to go out on a limb and say absolutely not.

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deprenyl does create small levels of amphetamine metabolites
caber will not be detectable

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My recommendations still stand.

Zoloft is an SSRI. You need to avoid SSRIs. It is mildly dopergenic.

Trazodone as a sleep aid. Can improve mood.

Deprenyl to increase dopamine. 10mg/week as a starting dose.

Wellbutrin to increase dopamine with some stimulant action. Do not take past mid afternoon.

Cabergoline to increase dopamine and lower prolactin.

All of the above are very good at having no to very low side effects with the exception of Wellbutrin which can be overly stimulating for some. That might be something that you need to compensate for the changes from years of stimulant use. When mixing dopergenic drugs, you really need to mindful of the combined effects. A mix can be useful as these drugs to act differently in different parts of the brain. I found that caber eliminated any need for Wellbutrin overnight.

And adex to modulate E2 levels as elevated E2 oten causes mood and depression problems.

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Maybe someone can help me out here. I’m on antidepressants. 150mg wellbutrin and 10mg paxil per day, both of those being pretty much the lowest prescribed doses. The depression is pretty much under control but unfortunately I’m having some sexual side effects (ie. very low sex drive). From what I’ve read, antidepressants can raise prolactin. So maybe that is part of the problem?

The real question is if I’m already on an SSRI (paxil), would it be safe to take selegiline at a very low dose alongside the paxil in hopes that I’d get a boost to my sex drive? I’m not afraid to ditch the paxil if that is necessary however.

38

Have you tried cognitive behavioural therapy? I’m not suggesting you discontinue treatment, but maybe it could help you. I suffered similar sides from SSRIs, and I would never take them again.

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[quote]bushidobadboy wrote:
Someone mentioned a thread dedicated to this great drug.

No, it’s not a steroid, though I might class it as a sort of performance enhancer, if you count improved libido mood and sleep patterns as ‘performance’, lol.

So what is it? As a MAO-B inhibitor (in regular doses), this drug inhibits the enzyme that oxidises dopamine, meaning that more is left in the system to be released and reuptaken.

Why is this of interest to me, a steroid-using individual? Well since it is a well established fact that dopamine antagonises (‘counteracts’ in laymans terms) prolactin, and that since elevated prolactine may be an unwanted side-effect of certain pro-hormones and steroids, and that since prolactin has inhibitory effects on libido (and mood) in men, you can see the possible use for a drug that reduces it.

Now there are other drugs that will achieve a similar aim, however they are either unstable (liquid cabergoline), expensive (tablet caber) or harsh on the system (bromocriptine).

Selegiline is cheap and only needs 2.5mg ED (or EOD if you are sensitive) to create a pleasant lift in daily energy, mood, libido, etc.

In fact, we did a trial study group over on enhanced-minds. com which you guys can read up for yourself.

In a nutshell then: selegiline is a cheap, reliable way of reducing that nasty brain chemical that may be what is f**king you up in the bedroom, post cycle. Side benefits include happiness and improved daily energy.

Got it?

BBB[/quote]

Hey BBB,

I’m trying to find this study on enhanced minds but to no avail! I might be on the wrong site! Could you or someone link it to me? Cheers.

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Apparantly you can eat cheese, without getting f*cked up blood pressure wise, with low dose Selegiline.