Hello everyone! I’ve been following a testosterone enanthate regimen for over 12 months now and would like to share my experience while seeking some advice.
I’m a 43-year-old male, not overweight, and I train 4-5 times a week. My regimen consists of taking approximately 60mg of testosterone enanthate (PRIMOTESTON DEPOT 250mg/1mL injection) every 4 days. I recently received my bloodwork results and haven’t been taking any aromatase inhibitors (AIs).
Sex Hormone Binding Globulin: 16 nmol/L (reference range: 13-71)
My E2 levels seem higher than the desired range, so I decided to adjust my dosage by taking 60mg every 5 days instead of every 4 days, in an attempt to lower my E2 levels.
Before making this change, I didn’t experience any nipple sensitivity. However, after the adjustment, I’ve started noticing some symptoms, such as increased awareness in the nipple area. It seems unlikely that my E2 levels could have worsened, so I plan to get my bloodwork done again after 3 months on this new 60mg / 5-day regimen.
I do have a prescription for an AI but would prefer not to use it if possible. Any thoughts or advice on managing my elevated E2 levels and related symptoms would be greatly appreciated. Thank you!
Did you encounter this increased awareness before or after seeing your lab results?
Men on TRT will typically have higher estrogen and DHT levels versus naturally. If you’re not symptomatic and feel good, the AI shouldn’t even be part of the discussion or your thought process.
I didn’t experience any symptoms before getting my recent lab results, but I’ve likely become more conscious of them due to the elevated E2 levels indicated in the tests.
I plan to share my bloodwork results after following the adjusted 5-day split regimen for a couple of months. For now, I’ll stick to my current plan and see how it goes.
I’ve decided to avoid using the AI at this stage. Thank you for your input and support.
By switching to e5d you’re lowering your trough, your overall level will take a few half lives to drop but that initial trough when missing a day is a bit lower.
Chances are on that extra day your e2 which is lagging behind is still slightly raised is proportionally higher compared to the lower test trough.
When e2 starts to outweight T, we get sensitive nipples.
You were doing 60mg e4d, thats 15mg per day so 105mg per week.
I’d maybe have tried 45mg e3d to narrow the band of peak and trough rather than lowering overall doseage (still the same quantities but less spike- which some suggest causes more aromatisation).
Without being able to scroll back as I write this, when were the bloods drawn in your schedule? Normal method is to generally do the bloods the morning of when you are doing your jab.
Thank you for your input. As anticipated, the blood samples were taken on the morning of the scheduled injection date, which was Day 4.
I had thought about using a 45mg dose every three days, but in Australia, we have pre-filled 1ml syringes. So far, I haven’t found an effective method to divide the doses into increments smaller than one-quarter.
Should also be considering the half life of testosterone enanthate being approximately 4-5 days as well?
If you had to pick would you choose the 45mg e3d, instead of the 60 e5d (or e4d)?