If your mood issues are under control then that is great, if you feel like it could still use improvement, MENT, even at 5 mg/day has been working wonders for me.
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P5P is for prolactin control, 5HTP will be better for mood, serotonin production
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Both are necessary for serotonin production. 5-HTP is 5-Hydroxytrypophan. For the decarboxylation reaction to serotonin (5-Hydroxytryptamin) P5P (Pyridoxalphosphate, active form of vitamin B6) is necessary.
Thereās been studies in monkeys showing that P5P increases serotonin.
By the analogous mechanism with dopamine P5P increases dopamine. By that it decreases prolactin.
5-HTP seems to pose problems with competition for the enzyme (dopamine is lowered). P5P actually is unbiased in its highetening of these neurotransmitters.
If we are already on the topic. I think itās highly interesting that P5P decreases prolactin production induced by nandrolone. This shows that nandrolone effect on dopamine/dopamine receptors is to blame for the prolactin effect.
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Progestogens interfere with dopaminergic transmission in vitro/within rodent models, there is validity to your hypothesis. Particularly given dopamine agonists are used to treat prolactinoma. If 19-nors mediate a particularly strong effect re dopaminergic dysregulation (which they doā¦ Receptor de sensitisation) your hypothesis may indeed be correct.
Yeet
Florp
Floop
Dooptoopity
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9/3/21 Update:
Iām glad to hear that. I saw that in your current cycle log. Thanks for the tip!
Thanks for the tip! P5P is working for now and I have it on hand already. But Iāll keep 5HTP in mind. I just watched a vid on it the other day.
So, 1 week in, zero visible to physique thus far. so, no need for pics. Changes have all been mental.
Anxiety has increased, as it always does when Iām on NPP, but P5P has helped me not take it out on another people.
Confidence is also way up, but this is no surprise as I always experience this when I bump Test higher.
Insomnia is a bit worse than usual but, again, no surprise there, as NPP always causes me insomnia.
Appetite is insane and hard to control. I can definitely eat A LOT more on NPP without gaining fat, than on Test alone. and I really enjoy that, but I have to be careful not do overdo it.
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9/11/21: two weeks inā¦ā¦the good, the bad, thoughts, and pic.
Good: traps have popped, body weight has gone up a smidge, all muscles look a little fuller, confidence is up, libido is up.
Bad: appetite is very hard to control, bad fatigue throughout the day, strength has dropped in all compound movements.
Thoughts: Iām noticeably fuller, especially in traps. Family and friends have commented. Weight has gone up 2 pounds and waist has stayed same. No other upper-body hypertrophy so far, which is really disappointing, because that is the goal of this cycle. My performance in lifts that require fortitude is up. Making great progress in loaded carries and high-rep death sets. Performance in lifts that require maximum momentary power have suffered by about 10%, though. This change is no surprise, as NPP always kills my low-rep strength.
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Luv the progress report @Professor_Hulk but have to ask why add the AASās if they bring you anxiety and insomnia? Not to mention how they trash your lipids. Have you ever considered a gram of T and nothing else? All that said your latest pic is awesome. Your traps really pop along with your delts pecs biās and triās.
I suffer from anxiety and insomnia and sometimes they overwhelm me. So that can be a focus I see more than others.
I am enjoying reading your thread. Wishing you all the best.
There goes my interest in NPP 
Thanks for the encouragement! Saw the pics you posted the other day of your transformation from 50ish to now. Wow man! Legend!
Good question. I have always really enjoyed physical exertion in one form or another. It started out as a coping strategy as a child. I was beaten, drugged, and raped by three different stepfathers during my childhoood. My mom sure knew how to pick āem. I was a troubled kid and needed an outlet. I started out in martial arts. Then added in strength training, then football, then extreme sports, always more, more, more. I was a very angry young man and pushing myself always made me feel better. So from very early on, my brain was just wired that way. Mad at the world? Just go do some high-rep squats or ride an ATV 75mph through the woods. Problem solved. Around age 35 ish, something happened. I couldnāt recover from all this anymore, and even wanted nothing to do with most of it. The only thing I never stopped doing was lifting heavy weights. I no longer enjoyed it, but I still just did it. Anyway, I was dog tired all the time, got injured often, always depressed, had no interest in life, hobbies, or even sex. Fed up one day, I went to a T clinic and my T levels were 144 ng/dL. I hopped on TRT and felt like my old self again, and enjoyed lifting weights again. for a while. Then, I didnāt, and started to slowly feel like crap again. I called another clinic and told them this. They put me on 350mgs Test a week. I felt better again, a lot better! For the first time in my life, training worked like itās supposed to: lift heavy, eat a lot, sleep a lot, and actually be able to lift a little more each week. I also regained interest in old hobbies, enjoyed life more. As all of us on here know, this is a very, very addictive feedback loop. Leaves you always wanting more and more. More muscle, more confidence, more strength, more libido. You get more, than you want more still. Thatās where Iām at now. I am the biggest and strongest Iāve ever been in my life and donāt ever want to go back. In fact, Iām not even willing to just maintain. Iām always seeking more. So, thatās why the AAS. I train really, really hard, as an outlet. So hard that if I were a mere mortal, it would kill me. On AAS, I can actually recover from it, progress, enjoy life.
Many, many times my friend. Iāve experimented up to 500mgs of Test a week. I donāt feel good that high. The reckless side of me, the devil sitting on one shoulder, has always told me āJust stop playing around with baby doses, man up, and do a gram a week. Then youāll see some REAL results.ā The much smaller, quieter, angel sitting on my other shoulder always says ājust be content with where youāre at. Keep the doses low, stay safe, take care of your health.ā I fear the angel is losing. Iām hoping to see some good numbers from this cycle. If I donāt, a run of 1g per week may be in my future.
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As you know very well, you gotta run it and see how it treats you. Some dudes DO get low end strength from it. I just donāt. It gives me high-end strength like a mofo, though. Week 1 of Jim Wendlerās BBB, i went with 5x10 at 70% TM, because I knew the prescribed 50% would have been way too light. I absolutely crushed all 50 reps. Week 3 it came time to hit the 1+ PR set and I missed a weight Iāve easily hit a million times.
This was not just a one-off bad day either. This happens to me anytime I have ever run NPP.
So why am I running it, you might wonder?
What it consistently DOES do for me is add upper body size, which Iām trying to do right now. My upper body lifts have stagnated forever now. I think I am at the strongest I can get at current upper body size and the only way I will get stronger is to add a few pounds of beef up there. Mark Bell talked about this in a video I watched one day. He said your bench could be stuck for a lot of reasons. If youāve tried technique, tried different programming, etc and nothing is working, You may just need to get bigger. You canāt expect to bench much more than 315 with sub-16inch arms. You just donāt have the beef to support that weight.
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This is not my experience with NPP. It increases both my high and low rep (maximal) strength. I personally think NPP is a wonderful drug for strength and recovery.
I havent done anything deca-like since i was like 20ā¦ Maybe i will try it someday thenā¦
9/18/21: 3 weeks complete
The good:
- Weight is up 6 pounds, from 205 to 211.
- Arm size is up .25ā from 15.5 to 15.75
- Traps have absolutely blown up
- Iām able to tolerate a lot more volume per session. The BBB template is a piece of cake and I have to resist the urge to do more.
- Libido is very strong. This is both good and bad. When the wife is game, Iām level 10. Whatās not fun is wanting almost every single woman you see and not being able to do anything about it. Man, I wish I had done this stuff back in my single days.
The bad:
- Anger/aggression are hard to control. I have to be ever vigilant and avoid stressful situations as much as possible.
-joint and connective tissue pain. This one is really weird because itās the exact opposite of what NPP is supposed to do.
-acne. Not a big deal, but annoying nonetheless
Pic:
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Weird that nandrolone is causing connective tissue problems
Like you said, itās supposed to do the opposite
Also surprised it causes aggression, Iāve heard deca causes depression in some, but never heard of 19-nor aggression except from tren
Study on 600mg/wk was indicative nandrolone seemed to increase aggressive thoughts, whereas testosterone at same dose on average didnāt
Nice traps/neck btw
Iāve struggled with anxiety and depression my whole life, but havenāt had any issues on AAS. I may have had some very mild depression on deca, but it was more like lethargy, perhaps from the weight gain. I actually love EQ and feel less depressed and less anxious than ever before so it really does depend person to person how you react
Another example is I love tbol but got nothing from anavar even at high doses. My significant other said āif youāre on something, it isnāt workingā while tbol was a miracle drug like everyone else describes anavar
Iām so glad I gave EQ a try as the mood boost is worth taking it even though it should have turned me into a basket case with my history of anxiety
@eyeoftheneedle76 do you know if your depression/anxiety is a lack of Serotonin(ssriās to boost) or GABA(benzoās to boost)? That could be why these AASās affect you differently.
Yup, NPP is a genuine pain in my ass. It always kills my low-rep strength and makes my lower back, hips, and knees hurt like hell. The only reason I take it is because it never fails to put size on my upper body, which is the focus of this cycle, for me.
Thanks unreal!
I donāt know if it causes aggression on its own. When I am not triggered/provoked, I donāt have aggressive/angry thoughts. What it definitely DOES do to me is make me extremely irritable and more likely to respond aggressively. I have to be careful at work, where I am surrounded by idiots. And I have to be extremely careful at home, around my family. I have three teenagers, so as you can imagine, I am constantly triggered at home.