Post Finasteride Syndrome

Hi guys,
Im suffering of post finasteride syndrome and I would like to know if cjc no dac requires a pct. Obviously I did bloodtest and everything looks fine, currently I’m having sleep issues and sexual disfunction. I tried hcg which helped me but still far to be cured so I’m thinking to use some supplements to fix my neurosteoids and a friend of mine suggests me to use cjc no dac for 2 months but I very afraid about sides effects. Thanks to who will answer me

What does CJC have to do with curing your PFS? It’s an unrelated compound if even effective.

1 Like

How’s your libido? How did HCG help you?

You want to increase androgen receptor sensitivity by boosting your GH levels for 2 whole months? Color me confused.

1 Like

Samsies. If I had a hormonal imbalance from PFS, which my have been my problem as a 10 year Propecia user, I would think a solid TRT program would be the fix.

1 Like

This or if OP is afraid of TRT, then maybe running L-Carnitine for an extended period of time… good luck with those injections though, they hurt like a mofo.

hcg doesn’t improved my libido but in general my mood is better.

i have no androgenic disorders, my hormones are working fine and i don’t need trt. I am currently taking supplements to balance my neurosteroids. i had thought of including cjc no dac in my protocol just to improve my sexuality.

… Do you, or do you not suffer from PFS?

1 Like

I am just chiming in to say that I am assuming @nick87 is likely born in 1987. Why that is important is that mid 30s is a very common time in a guys life when libido goes down. It’s also where some guys see ED issues.

I am not saying for sure PFS is not a real thing. It might be although not proven. Some (2-5%) certainly get short term side effects while on the drug and studies show that. Every study that has followed up with those that have gotten sides has shown that in a short amount of time off the finasteride that the sides went away.

It just doesn’t make sense to me that if drug has cleared out for months, that ongoing sides like reduced libido or ED would still be present.

I think if sexual changes do happen, that it is pretty natural to blame it on finasteride. It’s also why I think people have the on going side effects after stopping the drug (because it wasn’t from the drug).

Funny fact, basically nobody ever thought they had ongoing side effects from finasteride when used for BPH or the early days of propecia. It wasn’t until the PFS foundation came around that it was common for people to think they had ongoing side effects from finasteride.

1 Like

I certainly understand where you’re coming from - and it makes a lot of sense too BUT…

Finasteride works by binding to your androgen receptors - therefore blocking (or reducing) androgenic hormone uptake (test, among others).
Assuming Finasteride was only taken once balding began, I don’t see how it would be possible for results to be achieved long-term after stopping Finas without also having poor androgenic reception long-term.

I think Finasteride is a game of trading male pattern baldness for lower testosterone uptake. Where this comes into play for being able to prove it… Your body would still produce the same amount of test (theorhetically), but you would suffer Low T symptoms without having bloodwork to back you up - entirely due to androgen receptor insensitivity.

IDK, it makes sense to me, but you do bring up good points.

2 Likes

It inhibits the 5-AR enzyme. What it does is limits (reduces by about 70%) the enzyme from converting testosterone to DHT. Your androgen receptors should still be free for testosterone or DHT to bind to.

You are correct here. It won’t work unless you are taking it. You take it as long as you want it to work. If you stop taking it, you will start to lose hair (assuming you were balding before).

A natural taking it will produce more testosterone while taking it. Not a large increase (I think I’ve heard around 10% increase). Dutasteride raises testosterone more so than finasteride.

I underlined that last part, because I think it is important for guys to keep in mind that sexual dysfunction is very common for men as we age. It’s really a natural thing to blame it on something when you take a drug, however, it might just be aging.

1 Like

Wish you were right but PFS is very real.

And most of the “studies” trying to write off PFS as a mental issue or because of aging have been debunked already. Many of them are also done by vested interests like dermatologists who make money of it.

If you really interested in the science read this site:

1 Like

Umm, that’s not exactly a scientific website, but there’s plenty of research to counter this too.

Never trust a ‘scientific’ website that references Twitter threads as supporting arguments for its’ cause… Also, never trust a scientific website that has an obvious bias.

That site looks kinda biased IMO.

The studies I’ve thought were good were more so on the efficacy of the drug. They list drop out due to sides and some of the studies followed up on the side effects. IIRC, there were two studies in the 90s that did this. They had study sizes in the thousands.

I believe the burden of proof here still lies with those that claim it exists.

I also think it’s very possible that things like libido / ED are prone to mental games. I certainly agree that some guys have issues while on the drug, and can’t take it. I think some of them get in their heads about sexual performance afterwards.

I’ve noticed this myself. I’ve had a couple of lack luster performances in the past (both before and after finasteride). It might have just been that I was really tired for a morning session or something. But it took me awhile to get back to my self as I was questioning myself.

Another thing to mention with finasteride is that many guys experience a heightened libido (I did) for a month or so. That did go away for me. But, it might be easy to think my libido is now lower, but it’s where it was pre finasteride IMO. It’s just not as high as it was when I initially started. I think perhaps some of the people complaining about low libido after deca or tren might be in the same boat. They had raging libido while on, so now it seems low, but it probably is more in line with normal.

I have been suffering from post finasteride syndrome for 8 years and pfs exists and is real. men who suffer from this disease are thousands and some manage to recover after stopping the drug and others not. The pfs is different from person to person and mine is neurological and on the other hand I am in contact with a researcher who is studying the effects of finasteride on neurosteroids so it is true that there is a disorder with the receptors but everything derives from neurosteroids, at least for me. I just wanted to know if cjc no dac requires a pct. I don’t mean to sound arrogant but I am well informed about pfs. thanks everyone for the answers anyway.

1 Like

You would have gotten a more direct answer by leaving out the PFS then.

And no, CJC doesn’t require PCT, although I’m unsure what you hope to achieve with this… i guess it doesn’t matter.

I know that peptide can help my sexual disfunction. thanks for answer anyway

Uhm no, the guy from the website is a scientist himself.

He even wrote a scientific paper about what could cause PFS. Check: A proposed explanation of lasting dysfunctions after use of finasteride or dutasteride – Finasteride Info

But you’re right about being sceptical about “science”, especially from companies who have already been caughty lying and manipulating studies like Merck, you know the ones who made finasteride. Let’s take a look:

Lawsuits claim baldness drug Propecia causes sexual problems and depression. The judge sealed evidence – uncovered by Reuters – suggesting the maker downplayed the side effects. A widow wants the truth out.

Merck has been involved in MANY scandals and study manipulation:

Merck Manipulated the Science about the Drug Vioxx”
Scientists from the pharmaceutical giant Merck skewed the results of clinical trials in favor of the arthritis drug, Vioxx, to hide evidence that the drug increased patients’ risk of heart attack.

Tragically, Merck’s manipulation of its data—and the FDA’s resulting approval of Vioxx in 1999—led to thousands of avoidable premature deaths and 100,000 heart attacks.?Dr. David Graham, the Associate Director for Science and Medicine in FDA’s Office of Drug Safety, testified in 2004 before the Senate Finance Committee that the FDA’s failure to recall Vioxx earlier had resulted in as many as 55,000 premature deaths from heart attacks and stroke, calling it the equivalent of allowing “two to four jumbo jetliners” to crash every week for five years. Even years after discontinuing use of the drug, patients who have taken Vioxx continue to experience complications.

“Merck Agrees to Settle Vioxx Suits for $4.85 Billion”
Three years after withdrawing its pain medication Vioxx from the market, Merck has agreed to pay $4.85 billion to settle 27,000 lawsuits by people who claim they or their family members suffered injury or died after taking the drug, according to two lawyers with direct knowledge of the matter.

Problem with most of the studies regarding “safety of finasteride” are flawed by design. For example most of them only have study subjects of older age and are done by questionnaire, etc.

Also here’s a good breakdown of one of the many manipulated “studies” to try and paint the picture fina is safe: Meta-analysis launders safety data from old pharma trials; blames patients for drug harms – Finasteride Info

No, what you’re experiencing is not normal at all. (unless you’re 50+) You’re libido getting lower is not normal at all and a clear sign of finasteride damaging your body.

And yes there is proof it exists;

Other than thousands upon thousands of anecdotal reports from different men of severe adverse reactions to the drug appearing on the internet in the decades since it was approved for sale, evidence of objective differences between PFS patients and control groups has now been established.

https://journals.plos.org/plosone/ar…0237#abstract0

The ratio of AR positive stromal cells % to serum testosterone concentrations was 2-fold higher in cases than in controls (P?=?0.001). Our findings revealed that modulation of local AR levels might be implicated in long-term side effects of finasteride use. This provides the first evidence of a molecular objective difference between patients with long-term adverse sexual effects after finasteride use versus drug untreated healthy controls in certain tissues.

We also reported abnormal somatosensory evoked potentials of the pudendal nerve in PFS patients with severe ED, the first objective evidence of a neuropathy involving peripheral neurogenic control of erection.

Data obtained on neuroactive steroid levels also indicate interesting features. Indeed, decreased levels of pregnenolone, progesterone and its metabolite (i.e., dihydroprogesterone), dihydrotestosterone and 17beta-estradiol and increased levels of dehydroepiandrosterone, testosterone and 5alpha-androstane-3alpha,17beta-diol were observed in CSF of PFS patients.

Finally, finasteride did not only affect, as expected, the levels of 5alpha-reduced metabolites of progesterone and testosterone, but also the further metabolites and precursors suggesting that this drug has broad consequence on neuroactive steroid levels of PFS patients.

https://www.jsm.jsexmed.org/article/…817-9/fulltext

Using novel ultrasound technology, 96% of men with PFS and ED demonstrated heterogeneity in their corporal tissue at maximal pharmacologic erection. This new protocol is able to show that PFS men complaining of ED may have an underlying biologic pathophysiology.

So, three objective differences in men with PFS

  1. Double the androgen receptor expression compared to non-PFS control group
  2. Cerebrospinal fluid readings of PFS patients showed significantly lowered levels of several hormones and neuroactive steroids and “abnormal somatosensory evoked potentials of the pudendal nerve were reported”
  3. Ultrasounds of PFS patients’ genitals showed evidence of a potential biologic pathophysiology

Another fun fact, it’s also used by transgenders for transitioning: Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used mainly to treat an enlarged prostate or hair loss in men.[2] It can also be used to treat excessive hair growth in women and as a part of hormone therapy for transgender women.[3][4] It is taken by mouth.[2]

Also let’s be serious here. The ones trying to minimalize the risks of 5ari’s like fina and duta are the people with vested interests and balding guys who put all their hope in these drugs to stop their hairloss.

Think about it logically too. Do you actually believe blocking the most androgenic hormone for years and years will ONLY affect the state of your hair?