Smoking 25g of MJ would be quite the experience. I think it would actually be quite difficult to do.
Edit. You said you said .25 g. That is reasonable to do.
youād probably get sick, throw up and pass out before finishing 25g unless you have an enormous tolerance, in which case Iād think perhaps one should re-assess their prioritiesā¦ Respiratory irritation alone would also serve as a mitigating factor.
Could be done through ingesting brownies, but once again youād probably get very, very, very sick. You wouldnāt die (well, itād be possible for the elderly/those with pre-existing cardiac pathology to die from this), but youād probably wish you were dead.
I use the reference of 0.25 as I believe thatās probably around the amount of cannabis most would put in a spliff.
Marco, first off, Iām so glad you are involved with Zitzman. To have someone not only believe in pfs but be willing to research it is amazing. I think heās on the right track with his beliefs.
Your story is very similar to my early days. I didnāt have the extreme dryness in hands though.
My last pill was ā09 believe it or not. Time does improve things, Iāve tried so many supplements and even prostate draining over the years.
Other than timeā¦ I would say when I started a small dose of synthroid, it seemed to help a little with the coldness, shrinkage. Helped my skin dryness a little which was never severe as yours.
I only started to consider testosterone and jump on board a little over a year ago. Went from testogel to compound cream to test cyp IM to test cyp + hcg to now just continuing hcg alone.
The two times I was nearest to 100% was early into testogel and maybe a few months ago with my highest dose of test and hcg combined. Unfortunately, my hematocrit and hemoglobin got a little high and had a strange feeling in my chest. Also, I have bph which my doctor says testosterone can make worse. Whether heās right or wrong, I took testosterone and hcg with the first intention of going off both eventually and hoping things restarted.
If not, I can always go back on. But, I had numbers in rangeā¦ maybe lowish-middle but in range before test.
When Zitzman says run higher numbers to activate the receptors I can say in my case, that may have worked. I believe at 45mg of test cyp every 4 days and about 150iu of hcg every 4 daysā¦ my T and FT were pretty high over range. E2 was over but not as much.
I had strong morning erections every single day. Oddly though, my orgasm sensation didnāt really improve and I think continued to slowly decline. I only started to lose a lot of the sensation a few years ago. The general numbness was and is kind of the same.
Thereās also stories of guys that got worse on testosterone so be aware of that.
Iām feeling not that bad right now. About 10 days off my testosterone. I went from about 80/week to 40 a month ago. In another month Iāll get blood work seeing how it is just being on 300iu of hcg every couple days.
If you end up trying hormone therapyā¦ I donāt know if thereās a disadvantage to adding testosterone after running on hcg for a while, but, I think trying hcg alone first and for months, could be a good start. Iād stay away from anti estrogens and if you try cream be careful of putting it on your scrotum because Iāve read about guys crashing after at first having great success. I believe it has to do with DHT going through the roof or maybe E2 going too low.
Look forward to your posts. Man, donāt worry about your hair, it means less than zero. Be glad youāre in touch with Zitzman. It took forever to get doctors to believe this. And anti-depressants, they can cause pfs on their own. I donāt want to say never touch them, but, if you can avoid them if at possibleā¦
Stay positive!
(I was never into weed but tried it and it may help orgasm sensationā¦ but, then I thought it made them a little worse withoutā¦ so I ended that experiment fairly quick)
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Hi Jay, i have read your posts, i feel very sorry for your ongoing numbness 
.
That is also my main concern right now, i am afraid that my ED and also the numbness i also have persist. Not quite one year ago i had great sex and i still canāt believe that i could never feel/experience that again.
I am certainly not taking any Antidepressives that mess with Serotonin. I know from my intake of Tramadol that in higher doses it will affect Serotonin and mess with things down there. Actually stopped it completely and just dealing with the pain.
I know that weed can enhance the senses and make sex very nice, but i got anxious from weed years ago and since than i donāt really enjoy it anymore. Also not a solution, in my opinion weed is much worse than alcohol, at least for me, makes me plain stupid and overly emotional and i also feel hungover the next day.
I will update as soon as i get the letter from the Doc.
This was now said two times in here and before somebody jumps off a cliff because he didnāt want to try antidepressants, Iāll inform you guys that there are a lot of different antidepressants, some of them, for example Trazodone and Tianeptin, are known to IMPROVE sexual function.
SSRIs and some others are known to decrease sexual function but then you should just try others first. ADs can do wonders for people.
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Your organs would say otherwise.
In terms of penchant for inducing dependence/addiction/cumulative toxicity to organs alcohol is leaps and bounds more toxic comparative to cannabis.
Problem with cannabis stems from patterns of use. As it is less toxic, doesnāt last as long and lingering effects for most tend to be less severe plenty develop a habit of using daily. Though as youāre specified you were getting tipsy on a daily basis. The cumulative toxicity isnāt comparable, if referring to daily intoxication, cannabis is the lesser of two evils.
As to cumulative impact on cognitive facultiesā¦ Not enough data on the matter. Individualistic predisposition differs too.
From what Iāve anecdotally observed, young adults (18-23) over in my university seem to have a far harder time reeling in excessive alcohol intake as opposed to cannabis intake. I happen to not be found of either, both give me a hangover and significantly impede my cognitive faculties the day after use. Either can be good fun if used occasionally, though I would never recommend someone pick up drinking or smoking cannabis recreationally as in the end itās all bad news. GHB is where itās at (jokingā¦ Donāt try this, itās like the crack cocaine of alcohol, it might be less toxic but the potential for abuse is leaps and bounds higher).
Of course individualistic predisposition also plays a role. Some might have a higher penchant for developing a dependence on cannabis, others gravitate towards drinkingā¦ Or sleeping pillsā¦ Or whatever.
Be carefulā¦
Mesterolone was patented for use as an atypical antidepressant. You can look at clinical trials regarding the matter.
That one tends to dramatically improve sexual function. If only mesterolone cipionate were still available!
Ok, to each his own. But no offense, i see you are a kid. I think alcohol is much more of a drug for grown up adults than weed. I also think that you exagerate the effects of moderate alcohol consumption on organs.
I used to smoke weed too when i was a kid, but at some point the anxiety, memory issues and hangover were too much for me so i stoped. When drinking on the weekends, i badly overdid it with hard liquor and the hangovers were catastrophic.
But i think as you grow up you learn to enjoy alcohol differently, i donāt like to get really drunk for example, just a little tipsy is enough.
I know that i dislike sleeping pills, meaning benzos, and i really think that you have to have some serious problem to be into that kind of thing if you donāt just take them to sleep. Even than the sleep quality you get is shit.
Never tried GHB, i heard it gives you the best sleep and also other things. But i donāt think that you can seriously compare this to a couple of beersā¦
Iād blame them they are idiots. The medical industry we have to deal with is such a pain in the ass. Their masters the insurance companies dictate what is to be prescribed . This is why so many of use turn to the dark web and we buy what is needed.
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It is with moderate alcohol consumption too. But we are all adults so do as you please 
I donāt bother posting much anymore but still read at propeciahelpā¦ thereās a new guy from China that just posted. Sounds like he hooked up with a top hormone doctor at their best hospital. Already starting research with this guy. The doctor is older and even started finasteride to further his knowledge. Thatās devotion.
I think our best chance is finding doctors like him and Zitzmann. Iām seeing one of the few doctors in Canada listed on pfsfoundation.org
This guy from China is getting dna sequencing done. Sounds like he improved some on Clomid and hcg. Might be worth it to check his story out.
My skin on my forehead is already drier since my last test shot about 2 weeks ago. Iāll probably give in again and go back on it. Probably should anyways until my next appointment end of June to discuss how I should properly go off.
I wish Zitzmann and that Chinese guyās doctor could talkā¦ and of course understand each other. Ha
Marcolainen I also use 4-6 oz of whiskey to help me deal with GADās my anxiety comes and goes at will with no triggers. My shrink told me whiskey works for some because it numbs a certain part of you brain the same part of your brain that benzoās work on GABA.
My GP doc took me down the SSRI path trying to boost my serotonin it made me so depressed I almost took my own life. My wife took me to the hospital she thought I was having a heart atack. It was a bad panic attack. The nurse gave me 1 mg lorazepam and in 20 minutes I was perfectly normal. BP down for 200/100 HR97 to 130/82 HR 64 I left the hospital with 10 pills. Thru experimenting I found I only needed 1/4 of a pill if I took it at the beginning.
Anyway this story is getting a bit long. I would like to suggest to you you ask your doc for an Benzodiazepine for emergencies only. lorazepam, Xanax, or klonopin. cut them in 1/4ās and just see. Flush them if they donāt work.
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Hi, i canāt really say that i have such severe symptoms, the anxiety i had in the past months became way better, it also wasnāt so severe that i had panic attacks and such in the first place.
In fact my whole mental symptoms got better, sleep still sucks but whatever. I took Benzos/Zopiclone for sleep the last months for sleep and i really dislike them, a Zopiclone would only still get me 3-4 hours of shitty sleep and although benzos with medium duration of action would put me down 7 hours i felt like a zombie next day.
I am pretty sure that if i could sleep normal again, get normal boners again and regaine libido and sensitivity i would be in a much better placeā¦
Of course alcohol works somewhat similar to benzos, itās an GABAergic, but like i said before i donāt respond like a normal person to GABA drugs anymore, just like others with PFS.
Cheers!
There seems to be some evidence of that but I donāt think it is conclusive.
I looked into 3a-androstanediol glucuronide and it is, as expected, not a direct measure of androgenic activity. It is a metabolite of DHT which is produced by target tissue for example skin. This happens when DHT penetrates skin cells, it then gets converted into 3a-androstanediol-glucuronide but that doesnāt mean it has been used by the cell. The marker is used as a proxy for activity but in my opinion actually only shows how much androgens got into the target tissue. So is there an issue of penetration into the cell if this marker is low? I donāt know, but believers in the free hormone hypothesis couldnt argue so as that would be impossible.
Iām looking forward to OPs report
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Hello again, thought i would do a lttle update.
Unfortunately, or maybe fortunately, my blood results from Dr. Zitzmann showed no abnormalities, including the CAG repeat numbers. All hormones, including progesterone metabolites are fine, minus the high FSH. So all in all, my bloodwork is perfect, minus maybe the drop in free test compared to where it once was.
So he basicly told me to wait until the one year mark after the last pill. If iām not better by then, he recommended trying out TRT.
I also had to do other labs in the last month because of my work and they revealed perfect organ heath.
Some more infos about me as a person: iām actually a medical professional, i am an MD in internal medicine, i have become one after 5 years of residency last year.
The problem with lots of doctors, including Mr. Zitzmann and maybe myself, is that many arenāt open to new ideas and observations. I showed him the low 3-a-diol result, he just plainly dismissed it. That is because he doesnāt know anything about it, and therefore rejects the idea because who wants to say āi donāt know anything about itā (as a professional). So thatās the problem with doctors, as long as you stick to what you have learned and what is true and tested, everything is fine, but god forbid something new comes up, full on reject mode as a tool of ego and image preservation. That goes to other people as well 
.
Because of that, like a wise man said once, i think itās better to say āi know that i know nothingā and to accept ideas, or at least not reject ideas that arenāt in line with your view.
Anyway, enough of this, back to the topic.
I got a friend of mine to test his hormones when i did mine last time. He is exactly my age, he is puffy fat, kind of gynoid, has a weak beard, has little bodyhair and i think has my level of baldness, just a different pattern with pronounced diffuse thinning but not much recession, but he shaves his head anyway and isnāt such a pussy about it like myself.
His total and free test was min range, DHT low , estro normal, everything else normal. His a-3-diol value was 1500 (compared to my well under the range 23). He sleeps well, gets up with a boner and bangs his wife daily. Also he acts really alpha macho sometimes, but i think that is more of a personality trait.
So what about me?
Sadly, iām still not any better. My head is empty and i have short term memory and verbal issues. Itās like somebody took my wits and my mojo. When ingesting a Tramadol it helps a little, the price being a completely numb, unable to erect junk, which brings me to the next point.
Boners plainly suck, Serotonine kills it for good. Thatās all iām gonna say about it because itās embarassing.
Sleep: absolutely dreadful. Most nights i wake up at 4am and canāt go back to sleep for 2-3 hours. Therefore, my energy levels are very low, at some point i take a Zopiclone which makes me sleep for 6-7 hours without waking up, although the next day iām very groogy, but at least my body is getting some rest.
Pumps in the gym are almost non-existant, also i donāt get sore afterwards, although strength is progressing with consistent low volume workouts. Midsection still sucks, face might be a bit puffy, not sure.
Tinnitus is still present from the moment i wake up until i get to sleep. Cigarettes and lots of caffeine make it worse, i gotta stop this shit.
My response to stress is very bad, i quit 2 jobs this year after being overwhelmed, this also starts looking bad on my CV. Currently working as a freelancer which is nice in a way, lots of cash, no longterm contract, but iām allways on the run, donāt form any meaningful relantionships and during my free time off i canāt enjoy myself because of the mess i am. (Writing this on a beach in greece, stayed 10 days, almost no enjoyment at all).
A month ago i got some Proviron from some shady internet vendor. I think it was bunk, tried it a week, made me a little more agressive (not in a good way), ditched the rest of the pills, packaging and the pills theirself looked counterfeit.
So all in all, iām not really better. And i canāt go on like that. Will fill my script for topical testosterone to see how i feel on that. If that doesnāt change a thing will get a script for injections.
So, there you have it, i am still experiencing my lowest low and am deeply regreting doing this to my body and my soul.
Cheers
Since you are a medical professional, you can understand literature and therapies very well, I suppose.
I see other problems though: quit the addictions. Quit caffeine, quit alcohol, quit cigarettes, quit marijuana and quit porn (if you endulge). Give your brain a break.
Also, if you are able to prescribe yourself drugs, why not start a treatment with antidepressants that are known to increase libido/stabilize mood/improve sleep quality? My choices would be, in this order: Agomelatin (ever tried melatonin?), Tianeptine and Trazodone.
I donāt know if you check all the boxes for clinical depression but I bet it would be enough for a diagnosis.
Iām sure youāll improve with enough time, but you have to let your body heal for quite some time. It would really be better to get your body at least the break it needs for that.
Sad to hear that you experience PFS. I donāt a have time to back up what im going to write with studies and anecdotes from other forums now.
But fix of PFS is really, androgens.
All of your mental issues are due to low GABA activity and lack of neurosteroids. We supplement Progesterone (25mg) mainly and Pregnenolone maybe Allapr. for those sides until they heal.
Take L- Taurine and before bed, Valerian Root for your sleep issues. They both increase GABA too.
Trestolone/ Sustanon (mid to high doses) + 250- 500iu HCG EOD
Or any other steroid which binds to ARs with a good affinity and agonizes them, causing downregulation. (PFS is upregulated AR)
This is for fixing your Androgen Receptor expression. A guy i know recovered with Trestolone within few days fully. I donāt know what happened after he quit since he is went ghost. Probably recovered still.
Keep in mind, donāt cycle Trest more than 4- 6 weeks. Stop using it and see how you feel. I would start without losing more time. Best of luck.
The problem with the studies and all the theories is that we can not certainly explain what PFS is. So i eould rather rely on peopleās personal anecdotes. I spoke to guys that did steroids and recovered quick, so that at least gets hopes up.
I should ditch my addictions, meaning nicotine, alcohol and especially cafeine are just habits. I donāt really indulge in porn, i realized in the past that itās a shitty habit.
Of course i am depressed, i am wary of that. I had some depressive states in my past, but those were based on very concise causes and acumulation of negative experiences. I am ashamed to say this, but even when my mother died i didnāt have such severe insomnia.
I have tried exactly those pills you mentioned, they either didnāt help at all or they did have worrysome side effects. And i also donāt want to rely on pills to sleep/function.
Right now iām as free as a bird and donāt really have much to worry about. But the fact that my body refuses to properly execute some basic physiological functions such as sleep and get rest, getting normal boners and not throwing 24/7 ringing at my ear really starts to getting to me. And also the ever growing suspicion that this might be the new me.
It is what it is, thank you for taking the time to read and write, apreciate it.
Can you please share your bloodwork here? Did you also measure IGF-1?
And from where your Free T dropped? What it was before?
Also, can you please read my Post Accutane thread if you have time. (The latest messages about AR upregulation and Bicalutamide and Mifepristone.)
I hope we will recover from this. Cheers.
Hi Marco,
I was wondering how you are doing now.
Iām also an MD with PFS for the last 4 years. Iāve tried so many things already, from dieting to steroids etc. Nothing helps. Still 0 libido, genital numbness, anhedonia, flat emotions.
Best regards
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