“it is sub lingual formula, with testosterone propionate encapsulated in Hydroxypropyl Beta Cyclodextrin.”
Anybody familiar with this ?
Thought might be quite interesting with some of the needle phobes I have seen receintly.
Interesting read on Cyclodextrin delivery method.
Guess I am not a medical genius to cypher some of that study 
So is sublingual a good or bad thing lol
Oh BTW nice avitar 
You have to ask yourself how it would survive the first pass through the liver, which being capsuled or not has no effect on.
I just wonder how much of it is absorbed sublingually and how much is swallowed.
It may allow more to be absorbed sublingually than swallowed, but it doesn’t matter. The most you can expect from a cyclodextrin in oral delivery is protection from the enteric acids. It does nothing for liver protection, so if you don’t get it absorbed sublingually then it’s subject to first pass metabolism and gastric acids. There was an interesting paragraph about peptide and protein protection, but as of now that’s no real help to us.
Also there is the problem about WHICH cyclodextrin to use…there would need to be studies on which worked best for test delivery–I don’t know of any such studies, although it’s possible they exist (I didn’t search), and I doubt any UGL would bother to actually do the studies so you’re basically left with a “yeah, this should work” mentality.
Bad news. But hey, maybe it works. On the other hand, you’d probably be better served to do it the old fashioned way. I dunno since I don’t have any firsthand experience with any AAS, least of all this one, but that’s what I think based on my background.
I may be mistaken but I read that test is too big to be absorbed sub…may be wrong…just read it somewhere.
[quote]Aragorn wrote:
It may allow more to be absorbed sublingually than swallowed, but it doesn’t matter. The most you can expect from a cyclodextrin in oral delivery is protection from the enteric acids. It does nothing for liver protection, so if you don’t get it absorbed sublingually then it’s subject to first pass metabolism and gastric acids. There was an interesting paragraph about peptide and protein protection, but as of now that’s no real help to us.
Also there is the problem about WHICH cyclodextrin to use…there would need to be studies on which worked best for test delivery–I don’t know of any such studies, although it’s possible they exist (I didn’t search), and I doubt any UGL would bother to actually do the studies so you’re basically left with a “yeah, this should work” mentality.
Bad news. But hey, maybe it works. On the other hand, you’d probably be better served to do it the old fashioned way. I dunno since I don’t have any firsthand experience with any AAS, least of all this one, but that’s what I think based on my background.[/quote]
If its absorbed sublingually it will bypass the liver. The problem is you might swallow some one time and less another. The levels in your bloodstream wouldn’t be stable.
[quote]heavyequipment wrote:
I may be mistaken but I read that test is too big to be absorbed sub…may be wrong…just read it somewhere.[/quote]
I’d think if you can absorb it threw your skin like the patches, you should be able to sublingually.
[quote]Hagar wrote:
Aragorn wrote:
It may allow more to be absorbed sublingually than swallowed, but it doesn’t matter. The most you can expect from a cyclodextrin in oral delivery is protection from the enteric acids. It does nothing for liver protection, so if you don’t get it absorbed sublingually then it’s subject to first pass metabolism and gastric acids. There was an interesting paragraph about peptide and protein protection, but as of now that’s no real help to us.
Also there is the problem about WHICH cyclodextrin to use…there would need to be studies on which worked best for test delivery–I don’t know of any such studies, although it’s possible they exist (I didn’t search), and I doubt any UGL would bother to actually do the studies so you’re basically left with a “yeah, this should work” mentality.
Bad news. But hey, maybe it works. On the other hand, you’d probably be better served to do it the old fashioned way. I dunno since I don’t have any firsthand experience with any AAS, least of all this one, but that’s what I think based on my background.
If its absorbed sublingually it will bypass the liver. The problem is you might swallow some one time and less another. The levels in your bloodstream wouldn’t be stable. [/quote]
Yeah, I know. I should have rephrased my post–I meant that if you do not absorb it sublingually, the best that can be expected is that the PROPER cyclodextrin will protect it from enteric/gastric acids, but its protection from liver metabolism is nil.
Thus, if you don’t absorb it all sublingually, you’re toast. Also, sublingual dosing is only really effective if you can keep it under your tongue long enough w/o swallowing, AND if you can get a constant, major portion of it to absorb consistently each time.
Dermal absorption and sublingual absorption are not the same thing.
By that logic, you could argue that you could eat your food just as efficiently if you just threw it in the blender and slathered it on your body.