On TRT, Low Progesterone, Low Libido, Thyroid/ Adrenals?

You require an expert in thyroid disorders, nothing less.

Do you know how I might find one? I assume the NHS will be no help and private endos have been useless in the past.

Also, how are my cortisol levels? (Posted above)

Word of mouth will be best, you can find someone in your area on one of these forums. You can use the search option for doctors in your area. Reviews online is also a good idea.

Cortisol looks good.

If you haven’t resolved this yet, you need to take your high E2 seriously. It’s almost twice what it should be. High E2 will cause all of the symptoms you’ve mentioned.

Yes re Wilson and book.

After IR you need to be posting temperatures again.

Cortisol is not shot low, so you are not at that end of adrenal fatigue.

Your high fT3 and lower body temps suggester tT3.

I do not get a good feeling from your questions about how you completed or grasped reading the sticky. So more required there. I know that you have school demands that are in the way. Perhaps these are part of a stress contribution.

Thanks for your response.

I believe you have misread the units. The first test showed E2 was too low and the second showed it was almost perfect. I am now on the same AI protocol that was used during second test and symptoms mostly persist.

Thanks

Some weeks after IR, temperatures were the same as before. I can post what they were but there is little difference, in fact they seem slightly lower than before.

I am 3 weeks into taking T3 medication at 50mg a day. I decided to do this as seeing an expert isn’t really an option for me currently.

Would you mind pointing out which areas you believe my knowledge lacks in? I thought I had a good understanding of this and have been reading elsewhere but perhaps not. Perhaps that I was too keen to start T3 medication?

Thanks

My first post, led to here from google search.
Have you been tested for Thyroid Antibodies/ Hashimotos ?
Your symptoms and experience seem similar to Auto Immune Thyroiditis- the antibodies made against the thyroid can leave you with hypo symptoms one day, hyper the next and all sorts of randomness with other numbers. I was treated successfully for hypthyroid for years until this year things went south majorly this year (was in the 500Kg club now cant even lift) and the tests for the Antibodies came back HUGE- just one avenue to rule out.
Thing is 90%+of sufferers are 40+ females so medicine and the net isn’t geared up for weight training guys experiencing it and often puts symptoms down to PED use side effects.
(its largely genetic…any family history of auto immune issues/ hypothyroid?)

Hey mate - curious if your symptoms have abated and if they have, do you know why?

Afraid not mate. Hope the story is different for you if you’ve experienced this.

Low progesterone indicates primary hypogonadism, it is something I have rarely ever seen in men without ASIH, low PGR. But 19-nors will shut you down hard.

You may want to discontinue androgens altogether and hit the testes with a high dosage of HCG for 2-3 months and then get labs to see if they are functioning. If they are, you will probably feel better and your sex drive will be back and you can go back to TRT and should feel good again.

If not you could be primary hypogonadal, but I bet its just the 19-nor that shut you down hard. So the HCG should work. I have also seen the GH peptides work wonders for men in this specific situation. I know it is a completely different axis it is stimulating, but it also affects the androgens ability to bind to the receptor. In other words, increased GH levels will make your testosterone more effective.

I like the IPAM/CJC the best. Hope this helps

Thanks for chiming in but my understanding is that It shouldn’t matter how hard you’re shut down if you’re on trt. You’re saying that I should get my HPTA up and running, only to shut it down again by getting back on trt and that will bring back libido? When people say they have HPTA shut down, they mean they have low endogenous test production. This doesn’t matter when I’m injecting exogenous test. Unless the HPTA produces something other than test which will effect libido that I’m totally unaware of.

Thanks

It does produce other hormones, and 19-nor jacks with a lot of things in addition to shutting down HPTA.

1 Like

Truth is testosterone is not very suppressive compared to estrogen or 19-nors. There are definitely different levels of shut down, your HPTA can be partially shut down.

Just like HCG partially stimulates the HPTA and is partially suppressive.

IMT won’t do 19-nors, we haven’t for years. Not good for you, if your TRT and just trying to be optimally normal male. GH peptides are the safe and more effective alternative.

Well maybe not more effective than Tren but hey lol Pick your poison.

Does it? Which hormones that affect libido?

Yes, so I have learned. Been increasing dopamine and dopamine sensitivity for the last few months, no change.
Next I’ll be looking at adrenals. 24hr cortisol came back normal but I’ve ordered a much more comprehensive adrenal test. Also organic acid testing and GI testing. These are rarely discussed here.

ou can really mess with the brain chemicals with that stuff. It’s hard on catecholamine recptors and possibly even production, Dopamine in particular.

I have been going off the premise that shut down is shut down. When I tested everything while on trt (pre -tren), LH and FSH were near 0. I will look further into this.

Lol trust me, if my libido ever does come back, and at this point, I’m not sure that it will, I will never take sex drive for granted again. Life is very different when you haven’t had a sexual feeling for almost 2 years. It feels like all motivation was subconsciously about sex. I have no passion for anything now.

1 Like

All these different hormones are made directly and indirectly through the HPTA axis. So just LH and FSH is just the tip of the iceberg. So by providing your body with the core raw materials to make all these different hormones that fill different pathways, and jump starting the HPTA, you should feel a lot better.

ASIH stands for Anabolic Steroid Induced Hypogonadism. It is not just a 2 way street, the hormones are suppressive and they desensitize the testes. The stronger the androgen the stronger the desensitization. So you induce secondary hypogonadism by ingesting exogenous hormones and in turn these hormones also desensitize the testes inducing primary hypogonadism.

Testosterone doesn’t shut you down all the way, it has been a while but in caucasian men in the 70’s it was studied as a male birth control, and testosterone was only 60 ish % effective at shutting down fertility, but when they added deca to the mix it shot up to 95% effective.

So my point, you need to re-sensitize the testes, in hopes that when you go back to your regular regimen the small dose HCG is enough to stimulate.

Hope this makes sense.

Edit: Remember this is a 2 purpose thing, desensitize and test the testes ability to function. Because if they cannot, HCG is a waste of your time when on TRT. And it may be whats making you feel bad. Only way to know is to stimulate and see what happens.

Yep. So I increased dopamine with tyrosine/ L-dopa but that did nothing. Next steps are to see whether vit B6 definiency or adrenal issues is causing issues with the dopamine pathway. That’s what the comprehensive testing is for.