So I’ve read conflicting things about running Nolva or Arimidex during the cycle at a low dose to combat gyno symptoms. Some say just run it as a precaution and some say just keep it on hand in case symptoms arise. I’ve also heard others say that you’d Ben stupid to wait for symptoms to arise as it’s too late by that point. Those same people swear by running a low dosage of nolva(20mg)or Arimidex(.5mg) ED or EOD during their cycle as a preventative measure. What are your thoughts? Also if you do agree with running nolva or Arimidex during cycle which one would you use? I’ve read that they are different in the way they work. One is a a aromitase inhibitor and the other is a serm. Just trying to figure out which one would be ideal to run during a cycle to combat gyno.
If it make any difference my first cycle will be a Test E only cycle. WIll look something like this:
W1-12 Test E 375mg(1.5ml) E3D
W3-14 HCG 250iu 3x per week
W1-14 Adex .5mg EOD or 20mg Nolva ED??
PCT:
W15-18 Nolva 40/40/20/20
Please let me know any critiques. Wanted to keep it simple as it will be my first cycle.
tren being run on first/second cycles (weightliftingwithoutlimits is permausing 1g tren weekly and started just after/on his first cycle, that’s why I tend to give him so much shit lol)
people running massive dosages of combined compounds first cycle
people running heavy doses of cutting agents first cycle (thyroid hormone, clenbuterol etc)
At this point I’m happy he’s just sticking to test, at least that’s a win
Personally if I venture higher, I find testosterone induces profound sympathetic nervous system stimulation, compounds like mast or even dbol (used for very short periods of time otherwise I feel shit) work out better in this regard. I reckon I’d like primo, but can’t afford it at 130$/100mg/10mL vial
If I knew for certain I could get legit, 100% accurately dosed primo i’d use it at 150mg test 100mg primo and never cycle
The answer to OPs question is undoubtedly tamoxifen. Preferably no ancillaries should be used, as even tamoxifen comes with its own set of primarily neurological risks (neurotoxicity perhaps present st high dosages). Estrogen is important for glucose/lipid metabolism, neurological balance, NO production, facilitates anabolism and more. I’ve said this exact statement so many times I should just copy/paste it somewhere and paste it whenever I need to say it. Tamoxifen doesn’t actually lower concentration of E in the body, just binds to receptors in tissues sensitive to the hormone (breast tissue etc) this estrogen can’t exert effects upon those receptors… an aromatase inhibitor (depending on type) will actually lower E/E metabolite concentration in the body by binding to aromatase reversibly (non suicidal aromatase inhibitor) high a high affinity, thus blocking conversion of androgen to estrogen as the enzyme is already being used. Examples are like… anastrazole or letrozole
Otherwise suicidal AI’s like exemestsne irreversibly bind to the aromatase enzyme, rendering it inactive (I say “killing it” because theoretically the enzyme is useless now), the only time you’re body will aromatase if you totally crush you’re E using this is when you’re body synthesises new aromatase.
Shortened version: SERMS bind to the ER in various tissues, AI’s bind to the aromatase enzyme
No, but there is a difference between puffy nipples and true gyno
True gyno is when the mammary glands have actually developed excess breast tissue. Prolactin induced gyno is very rare.
Prolactin (at least in breast tissue) upregulates receptors for both estrogen and progesterone, thus it is probably easier to get gyno on a 19 nor + aromatising compounds. Even test increases prolactin dose dependently, however 19-Nors have a far higher affinity for doing so. Prolactin itself is also responsible for enlargement of the mammary glands
Yea the 50 iu slin thing (actually I think it was quite a bit more) really blew me away. That’s like… acutely life threatening
I don’t believe there is a safe way to use insulin. If, for whatever reason you’re influx of carbs is suddenly unavailable… say you go to the bathroom to shoot you’re slin, come back and the dog has eaten you’re pizza you’ve prepared for yourself… now you’re ded
One of the sticky posts said that there are two camps that address what is a proper dosage for a persons first cycle. Some say that you will have the best results during your first cycle so hit it hard(1000mg/w or more). The more conservative and probably softer approach is to take it easy on your first cycle (500mg/w) as to see how your body reacts. So I decidedly on a happy medium so to speak, somewhere in the middle. I’ve got no problem running 500mg/w though instead.
Well you’re talking about two different types of medication. Each one does something different. There tons of threads on AIs, you should do your own research
I look at a 19nor and I get gyno starting. It has gotten worse with cycles but I have yet to have get true gyno from anything else.