New Guy - Question on TRT

Saw the Doc on 8/29. I got the results from the 7/26 labs. These were taken before starting TRT.

Estradiol 47 pg/ml 13-54 pg/ml

FSH 2.3 mlU/ml 1.55-9-74 mlU/ml Annotation: Low testosterone is due to Pituitary with understimulation of the testes. Male estrogen is normal. I told him that 47pg/ml might be normal but it is way high. Told him that 22 was optimal and he said we will adjust AI to get it to 22. (I’m starting to like this guy!)

LH 1.5 mlU/ml 1.1-8.6mlU/ml

Doc said FSH and LH were abnormally normal, since I had low test. He said the brain is not acknowledging that Test is low. What is the root cause of this??

KSman could you elaborate on “some get bad estrogenic side effects”. What would your suggestion be on amount of Clomid weekly? I will question him as to the possibility of changing to Nolvadex. I asked him if I could get HCG and he avoided the issue, I will persue this more. I have another appt in a month, he asked for new labs for TT, FT and E2.

[quote]FN257 wrote:

Doc said FSH and LH were abnormally normal, since I had low test. He said the brain is not acknowledging that Test is low. What is the root cause of this??[/quote]

Your high estrogen is the most likely cause of this. I guarantee if you took just an AI, you would see immediate improvements in LH/FSH and Total T. But you started TRT, right? So that ship may have sailed.

[quote]
KSman could you elaborate on “some get bad estrogenic side effects”. What would your suggestion be on amount of Clomid weekly? I will question him as to the possibility of changing to Nolvadex. I asked him if I could get HCG and he avoided the issue, I will persue this more. I have another appt in a month, he asked for new labs for TT, FT and E2. [/quote]

Clomid works by occupying SOME estrogen receptors, so the actual estrogen can’t do its job (which is good). The problem is that this increases your overall blood estrogen as your body tries to compensate, and this excess estrogen can bind to the receptors that ARENT occupied by clomid. This is part of the problem–other people have said this is compounded by Clomid actually eliciting an estrogen-like response on the receptors it is actually bound to.

Nolvdadex seems to do a bit better job at mitigating this.

But all of this is really acedmic and applicable for a non TRT context, because I still maintain that it does not make sense to run a SERM (like Clomid/Nolva) while you are adminsitering exogenous testosterone. You need HCG to keep the testes alive, not SERM!!!

Also, are you aware that SERMs and Anastrozole do not work well together? One blunts the effects of the other (I think it is SERMs that blunt the Adex), such that the combination of the two is no different than just takin the SERM. there is a stickey about this in the Steroids Forum (SERM/AI stickey).

I still maintain that taking a SERM with TRT is silly.

VT hit the nail on the head… this is a great example of why estrogen tests are useless and estradiol should be used. Sounds like your new doc actually cares about your well-being as well.

I’ve always been hot natured too, but worse sense starting TRT. People look at me funny when I mention I’m hot or ask if anyone else is warm. I don’t get gushing sweat but I do sweat more. I just attributed it to an increased metabolic rate.

I will update more later on my progress but want to ask this now. My doc finally agreed to let me use Hcg, where are you guys buying it? My insurance won’t cover it. Costco said generic was $68 for 10ml but couldn’t get it due to shortage. Novarel is $167 for 10ml. Is there a shortage? Just my luck to get Doc inline with SOP and can’t get it.