Multivitamin Selection

Nutrition
41

There is at least one thing that came up; I haven’t as yet looked past finding the first one.

1: Eur J Nutr. 1999 Dec;38(6):278-85.

Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans.

Hoffmann J, Linseisen J, Riedl J, Wolfram G.
Institute of Nutritional Sciences, Technical University of Munich.

BACKGROUND: Antioxidant concentrations in low density lipoproteins (LDL) are an important determinant for their susceptibility to oxidation and can be modulated by dietary intake.

AIM OF THE STUDY: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated.

METHOD: An antioxidant supplement consisting of beta-carotene, lycopene, lutein, canthaxanthin and alpha-tocopherol was given to six young women together with a standard meal. Using a cross-over study design, each subject received the standard meal without additional dietary fiber and enriched with pectin, guar, or cellulose in a random order.

To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured.

RESULTS: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase.

Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without. On average, pectin, guar, and cellulose reduced the increase of the lag phase (measured without addition of dietary fiber) by 38%, 22%, and 18%, respectively.

CONCLUSIONS: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and alpha-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.

42

[quote]Bill Roberts wrote:
There is at least one thing that came up; I haven’t as yet looked past finding the first one.

1: Eur J Nutr. 1999 Dec;38(6):278-85.

Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans.

Hoffmann J, Linseisen J, Riedl J, Wolfram G.
Institute of Nutritional Sciences, Technical University of Munich.

BACKGROUND: Antioxidant concentrations in low density lipoproteins (LDL) are an important determinant for their susceptibility to oxidation and can be modulated by dietary intake.

AIM OF THE STUDY: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated.

METHOD: An antioxidant supplement consisting of beta-carotene, lycopene, lutein, canthaxanthin and alpha-tocopherol was given to six young women together with a standard meal. Using a cross-over study design, each subject received the standard meal without additional dietary fiber and enriched with pectin, guar, or cellulose in a random order.

To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured.

RESULTS: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase.

Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without. On average, pectin, guar, and cellulose reduced the increase of the lag phase (measured without addition of dietary fiber) by 38%, 22%, and 18%, respectively.

CONCLUSIONS: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and alpha-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.[/quote]

So Bill…

it only mentions carotenoids and alpha-tocopherol. I am also understanding it to mean that the reduced effect is not an issue and the bioavailability is reduced in the gut.

am I reading that correctly?

and what supps are carotenoids and alpha-tocopherols? and if they are beneficial is there a way to enhance their absorption in the gut?

43

solgar makes a really good vitamin…

44

[quote]duddy wrote:
I think Mr. Roberts is the man.
[/quote]

QFT.

Thanks for taking the time to answer my question, Bill.

45

[quote]OctoberGirl wrote:
AIM OF THE STUDY: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated.

To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured.

RESULTS: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase.

Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without.

CONCLUSIONS: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and alpha-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.

So Bill…

it only mentions carotenoids and alpha-tocopherol. I am also understanding it to mean that the reduced effect is not an issue and the bioavailability is reduced in the gut.[/quote]

If, as is the case, improved resistance of LDL to oxidation is desired, then it is an issue that the fiber resulted in less improvement.

You are correct that it is saying that fiber reduced bioavailability.

[quote]and what supps are carotenoids and alpha-tocopherols? and if they are beneficial is there a way to enhance their absorption in the gut?
[/quote]

Carotenoids include beta-carotene, lutein, and canthaxanthin (used in this study) as well as for example lycopene, astaxanthin, and zeoxanthin. Beta-carotene as you know is a source of Vitamin A, while the others mentioned are beneficial antioxidants.

Alpha-tocopherol is one of the forms of Vitamin E. It is likely that what was found here regarding absorption is true for other forms of Vitamin E as well.

Absorption of these compounds is generally good. Absorbtion is better if some fat is consumed at the same time (quite little would be needed) for example with a meal. The study above gives reason to believe absorption will be better if the meal is low fiber.

In the case of a multivitamin providing genuinely ample amounts of Vitamin E including genuinely ample gamma-tocopherol, a moderate loss of bioavailability wouldn’t be such a concern as there is margin of error, but apparently it’s not optimal. In the case of a midgrade supplement that does provide some gamma-tocopherol but is quite stingy with it as most are (it is quite expensive stuff) then it really would be best to get the most out of that miserly amount that can be gotten and therefore take it at a time when fiber is not being consumed.

However, I would tend to think that carotenoid bioavailability, for those carotenoids supplied in smaller quantity such as lutein, astaxanthin, etc, is where the greater value or need is in optimizing bioavailability. There it probably really is significantly wasteful to consume such while failing to take in some fat at the same time or, it seems from the above, while consuming much fiber.

46

You’re welcome, Tom! And thanks, Duddy.

47

[quote]Bill Roberts wrote:
OctoberGirl wrote:
AIM OF THE STUDY: In the present study, the influence of dietary fiber on the antioxidant enrichment and the oxidation resistance of LDL after antioxidant supplementation is investigated.

To determine the resistance of LDL against copper ion-induced oxidation, the formation of conjugated dienes was measured.

RESULTS: Eight, 10, and 24 hours after antioxidant supplementation the isolated LDL revealed significantly (p < 0.05) increased antioxidant concentrations; addition of pectin, guar, or cellulose to the meal depressed this increase.

Concomitantly, the observed increase in the resistance of LDL against oxidation (measured as lag phase) was lower with dietary fiber supplementation than that found without.

CONCLUSIONS: These results indicate that dietary fiber supplementation decreases the antioxidative effect of a supplement consisting of carotenoids and alpha-tocopherol in LDL, an effect that is likely to be mediated by a reduced bioavailability of these antioxidants in the gut.

So Bill…

it only mentions carotenoids and alpha-tocopherol. I am also understanding it to mean that the reduced effect is not an issue and the bioavailability is reduced in the gut.

If, as is the case, improved resistance of LDL to oxidation is desired, then it is an issue that the fiber resulted in less improvement.

You are correct that it is saying that fiber reduced bioavailability.

and what supps are carotenoids and alpha-tocopherols? and if they are beneficial is there a way to enhance their absorption in the gut?

Carotenoids include beta-carotene, lutein, and canthaxanthin (used in this study) as well as for example lycopene, astaxanthin, and zeoxanthin. Beta-carotene as you know is a source of Vitamin A, while the others mentioned are beneficial antioxidants.

Alpha-tocopherol is one of the forms of Vitamin E. It is likely that what was found here regarding absorption is true for other forms of Vitamin E as well.

Absorption of these compounds is generally good. Absorbtion is better if some fat is consumed at the same time (quite little would be needed) for example with a meal. The study above gives reason to believe absorption will be better if the meal is low fiber.

In the case of a multivitamin providing genuinely ample amounts of Vitamin E including genuinely ample gamma-tocopherol, a moderate loss of bioavailability wouldn’t be such a concern as there is margin of error, but apparently it’s not optimal.

In the case of a midgrade supplement that does provide some gamma-tocopherol but is quite stingy with it as most are (it is quite expensive stuff) then it really would be best to get the most out of that miserly amount that can be gotten and therefore take it at a time when fiber is not being consumed.

However, I would tend to think that carotenoid bioavailability, for those carotenoids supplied in smaller quantity such as lutein, astaxanthin, etc, is where the greater value or need is in optimizing bioavailability.

There it probably really is significantly wasteful to consume such while failing to take in some fat at the same time or, it seems from the above, while consuming much fiber.[/quote]

Thanks Bill,

and thanks for the tip about taking the vitamins with fats.

48

any thoughts on this:

http://www.solanova.com/product.html?pid=11

49

[quote]FFBMikey wrote:
Honestly I don’t think multivitamins work. When I took Animal Pak I felt like I pissed out all of the vitamins an hour after taking them. Also many multivitamins contain two ingredients that negate each other (ex. Calcium and Zinc). My advice would be to save the money, get some BCAA’s fish oil and protein powder. [/quote]

BCAA’s have been proven over and over to be very ineffective and everyone is missing the point of multivitamins there not energy boosters it doesn’t claim that it just give you the vitamins and minerals you may be lacking and the high potency ones are higher in vitamins and minerals you need from training which you may otherwise be deficient which may otherwise may cause you to get ill easier or hinder your gains.

Just because you “cant feel” it doesn’t mean it’s not doing you any good.

50

I’ve been taking Animal Pak for a while and I’ll stand behind it. It’s not something you feel “kick in.” But ever since I’ve started taking it, I have never been sick and I’ve felt overall great despite being on a large caloric deficit and zero carb diet.

I’m also taking Animal Omega for essential fatty acids. It works very well with the ketogenic diet I’m on.

51

I hear USANA makes a pretty good multi

52

Was just hoping that someone could check out this multivitamin and let me know what they think of it. I recently had to switch to an iodine-free multivitamin, because high doses of iodine cause skin flare ups for me. I eat a well balanced diet and use a multivitamin as a backup. Thanks!

http://www.country-life.com/moreinfo.cfm?Category=6&Product_ID=86