Mixing Instructions PT-141

Here’s a thought based on what I was doing with hCG. Consider the idea of using a 30 g <=0.5" insulin pin and go right in at the top of the rectus femoris way above the blue dot below. Should line up level with midline of your groin. Can’t remember what your bodyfat is but flex the region to find your insertion (go way below that) and that should get you a decent IM injection if your BF is reasonabe. Make sure you think about what you are doing

image

Remember you want to go into the muscle (see red dashed circle below), don’t go in inner thigh (see major nerves).

Report back any change in onset of effect.

1 Like

My legs are pretty lean and all the different muscles are fairly easily identifiable. I’ll try this method, thank you.

From manufacturer:

image

Idea is to inject as close to target organ (in terms of effect if not action, thanks @lordgains for keeping me honest on these distinct concepts) as possible without doing something that can end in disaster. I’ve never has an issue with the high rectis injection but have had horrible experience with even a little above blue dots shown above. Note the high rectis shot is above what is shown as highlighted thigh region in the Vyleesi insert. Would be more like this:
image

Also, start on the LOW side of dosing and monitor effect with methodical dose titration over time. Don’t end up in the ER.

Ok, I see you did 0.8 mg previously. May want to start lower with new injection method.

For informational purposes only

1 Like

https://www.nature.com/articles/3900582

image

1 Like

The graph you posted is for Melanotan II, I assume that is similar. Is that a side effect of that drug as well? I assume it is based on the graph. In general, are the injections to make one tan easier also good for erections?

https://www.tandfonline.com/doi/abs/10.3109/15563650.2012.740637?journalCode=ictx20

More info. Yes related compounds. I think I’ve heard the slang term the “vacation” peptides.

MT-II (Melanotan-II)

Pharmacology

MT-II is a synthetic cyclic heptapeptide that was initially designed as an artificial tanning agent. Its structure is based on an earlier linear peptide, Melanotan-I, however cyclization was introduced to prevent degradation and allow both N and C terminal truncation of the peptide [38]. The pro-erectile activity of MT-II was reported as a significant unexpected reaction during a phase-I human trial of human tanning [39]. MT-II contains a seven amino acid sequence with homology to receptor binding portions of α-MSH and ACTH. The compound is thought to cross the blood brain barrier and has high affinity for the MC1R, MC3R and MC4R. MT-II has a similar affinity for MC4R compared with MC3R and may be considered “superpotent” because of its relatively high affinity for MC4R compared with the endogenous peptides α-MSH and ACTH (10-100 fold difference).

PT 141 (Bremelanotide®)

Pharmacology

PT-141 (Bremelanotide®) is currently the most studied melanocortinergic compound with regard to therapeutic potential for treatment of erectile dysfunction. PT-141 is a synthetic heptapeptide. It is a deaminated derivative and likely metabolite of MT-II. This compound has strong binding to MC receptors 1, 3 and 4, with a higher affinity for MC4R over MC3R. Application of PT-141 to HEK-293 cells expressing MC4R increases cAMP production, indicating that this compound, like MT-II, acts as an agonist [42].

2 Likes

Loving this thread

Interesting. It says to avoid the area 2” around the belly button. That’s always been my go to spot for sub q

Same here, done hundreds of HCG pins there without issue

Guideline to avoid people inadvertently giving an intravascular injection.

People without education or training will do all kinds of crazy stuff that seems reasonable to them. The point to the instructions and SubQ guidelines is to ensure you go SubQ not IV (with meds like insulin, etc).

Above we are talking about the potential to go IM instead of SubQ. Make sense?

Also can anyone think of another reason why you don’t want to inject anywhere near your belly button?

there is another side effect of it… brutal nausea.
me and my gf tried this both… we both got very horny but both got very sick at the same time… its basically throwing up with a hard dick.
no way in hell we could have had sex like that…

1 Like

What dosage was that at Hank? I agree its not worth the trade off it it makes you sick as well.

In one of the papers tareload shared the clinical trial dose for best effect/minimal sides was 0.025mg/kg of body weight.

I’m 77kg so that equates to around 1.9mg dose.

As a starting point i was going to use 0.5mg to guage reaction to it, thats a tiny dose?

I dont remember the dose. We tried it once, got sick, threw it out and never wanna remember that day. I had never been so sick in my life.

That sounds really bad, ive heard of people ending up in A&E at 6mg plus doses :open_mouth:

Kind of important. Glad you are feeling better!

Remember everyone, pay attention to mg/kg bodyweight when injecting stuff you have no experience with.

when i did it i knew how much i needed, its just that i did it once while back, the dosages are different than AAS stuff so i have no way of remembering it, because i knew i would never ever need to know again, haha.

1 Like

Gotcha. Just wanted to put a disclaimer for the reader that “more is definitely not better” on some of these injectables :slight_smile:

Definitely applies to this product i think :+1:

2 Likes

For Bremelanotide especially IM as discussed above, quite reasonable. Well done.

From the product directions I posted above, damn, you guys are impatient and refuse to read :slight_smile:

Read the directions before you use stuff. I guess there are two types of people in the world, those that read the directions and those that don’t. I recommend reading the directions before playing in Pharma land.

Im listening and reading :grin:

In fact im going to drop the 1st dose planned for tomorrow to 0.25mg and titrate from there.

No rush is there.

1 Like