Micellar Curcumin: 95x better absorption

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Curcumin-rebuilt.jpg1920×823 191 KB

Third-generation curcumin: 95x better absorption
Third-generation curcumin: 95x better absorption1920×823 191 KB

Ordinary of curcumin, with piperine, barely showed up in the bloodstream, but the new generation is 95 times more powerful.

Curcumin supplements are ubiquitous. And for good reason. Curcumin's effects are so powerful and cover so many critical areas – anti-bacterial, anti-atherosclerotic, anti-fungal, anti-inflammatory, anti-body-fat storage, antioxidant, anti-thrombotic, anti-erectile dysfunction, and anti-viral – how could you not take it?

Here's the problem: even if you take large amounts of curcumin, most of it is converted into inactive waste, a process called glucuronidation, which is how the body rids itself of things it considers pollutants. Your digestive system struggles to absorb what's left, and only tiny amounts are shuttled off to your body where it can do its magic.

Studies have documented that taking 3.6 grams (about 7 capsules) of ordinary curcumin (with piperine) produces nearly undetectable levels of circulating free-form curcumin.

And it's this ordinary curcumin that's found in almost all curcumin supplemets today.

Micellar Curcumin

Biotest chose to go with a lipidized form of curcumin that was invented, tested, and patented by neuroscientists at UCLA, sold as Micellar Curcumin ➔ Buy at Biotest. Take a single dose of Micellar Curcumin and high levels of free curcumin are detected in the bloodstream within one hour. Furthermore, high levels of free curcumin are detected as long as 24 hours later, showing that one daily dose is all you need for round-the-clock protection.

More than 50 studies involving humans have found Micellar Curcumin delivers a host of tangible health benefits, including eye and neural health support, healthy aging, joint health, reproductive health, gut health, and mood and cognitive health.

Biotest Micellar Curcumin

References
  1. Mangala Hegde, et al. Curcumin Formulations for Better Bioavailability: What we Learned from Clinical Trials Thus Far? ACS Omega, 2023. 8, 10713-10746.>
  2. Shah et al. Acute human pharmacokinetics of a lipid-dissolved turmeric extract. Planta Med. 2012. 48-PH5.
  3. Gota VS et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. doi: 10.1021/jf9024807.
  4. Cox KHM et al. Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study. Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678.
  5. Esfahani K et al. A phase I open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung. J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611.
  6. Scholey A et al. Curcumin improves hippocampal function in healthy older adults: A three month randomized controlled trial. Poster Presentation in 13th European Nutrition Conference - Malnutrition in an Obese World: European Perspectives (FENS). Dublin, Ireland. 2019: P3-01-02.
  7. Scholey A et al. A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19). Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19.
  8. Gupte PA et al. Evaluation of the efficacy and safety of capsule solid lipid curcumin particles in knee: A pilot clinical study. J Inflamm Res. 2019. 12: 145-152. doi: 10.2147/JIR.S205390.
  9. Koronyo, Y et al. Retinal amyloid pathology and proof-of-concept imaging trial. JCI Insight. 2017. 2(16). doi: 10.1172/jci.insight.93621.
  10. Santos-Parker JR et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailiability and reducing oxidative stress. Aging. 2017 Jan. 3. Vol 9(No1): 187-208.
  11. McFarlin et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. University of North Texas. BBA Clinical. 2016 Feb 18. 5: 72-78. doi: 10.1016/j.bbacli.2016.02.003.
  12. Santos-Parker JR et al. Curcumin supplement improves vascular endothelial function in middle-aged and older adults. Geront. 2015 Dec. 55(Suppl 2): 195. doi: 10.1093/geront/gnv554.01.
  13. Rafii MS et al. The biomarker initiative DSBI pilot: Proof of concept for deep phenotyping of biomarkers. Front Behav Neurosci. 2015. 9: 1-11.
  14. Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Centre for Human Psychopharmacology, Swinburne University. J Psychopharmacol. 2015 May. Vol 29(No 5): 642-651. doi: 10.1177/0269881114552744.
  15. Hazarey VK et al. Efficacy of curcumin in the treatment for oral health – A randomized clinical trial. Government Dental College and Hospital. Nagpur, Maharashtra, India. J Oral Maxillofac Pathol. 2015. 19: 145-52. doi: 10.4103/0973-029X.164524.
  16. Machida N et al. Effects of Solid, Lipid Curcumin Particles on alcohol metabolism - An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study. Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
  17. Frost S et al. Retinal amyloid fluorescence imaging predicts cerebral amyloid burden. Alz Dement. 2014. 10(4): P234-P235.
  18. DiSilvestro et al. Diverse effects of a low-dose supplement of lipidated curcumin in healthy middle-aged people. The Ohio State University. Nutr. J. 2012 Sep 26. 11(79). doi: 10.1186/1475-2891-11-79.
  19. 1Khattry N et al. Curcumin decreases cytokine levels involved in mucositis in autologous transplant setting: A pharmacokinetic-pharmacodynamic study. Poster presented at 54th American Society of Hematology (ASH) Annual Meeting. Atlanta, GA. 2012 Dec 08. Blood. 120(21): 3039.
  20. Shah et al. Acute human pharmacokinetics of a lipid-dissolved turmeric extract. Planta Med. 2012. 48-PH5.
  21. Pharmacokinetics of lipidated curcumin: Dose-concentration correlation. Unpublished, UCLA 2011-2012.
  22. Gota et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in patients and healthy volunteers. Tata Memorial Cancer Centre. J Ag Food Chem. 2010. 58(4): 2095-2099.
2 Likes
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Has there been any issues with liver impact for Curcumin?

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No, in fact, curcumin appears to be hepatoprotective, i.e., good for the liver. Of course, huge, huge amounts might prove otherwise.

2 Likes
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Thanks!

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The link to Longvida Optimized Curcumin® goes to a different product.

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Is this the same as the Curcumin in I-Well?

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No, it’s got the same stuff in it.

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Yes, same stuff.

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Is it the same Longvida that has been tested in this study?

https://www.researchgate.net/publication/326181864_Bioavailable_curcumin_formulations_A_review_of_pharmacokinetic_studies_in_healthy_volunteers

If so, wouldn’t NovaSol have an advantage over Longvida?

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Do you want to consider re-writing the 3rd - 5th paragraphs for more clarity? When I read them, several times I read it exactly the opposite of what (I think?) you were intending to say?? (Maybe it’s just me …)