I found some of my grandpa’s old diabetes medication in the cupboard. that glucophage stuff.
What does this do with insulin?
What’s the difference between this and glucophase xr (K-R-ALA) that designer supps. sells? Do they essentially do the same thing? When should I take this stuff if I do use it?
Any help greatly appreciated.
Metformin is likely to act by three mechanism.
Slows down carbohydrate absorption from the gut, reducing the height of maximal pasma glucose concentration.
Inhibits hepatic gluconeogenesis, (formation of glucose from amino acids) in the face of adequate glucose load and insulin (a mechanism that is deficient in diabetic patients, they keep making glucose from amino acids dispite not ‘‘needing’’ glucose and develop hyperglycemia).
An important mechanism of action is improved insulin sensitivity in peripheral tissue.
** No effect on insulin per se but because of the increased sensitivity, plasma insulin concentration would be slighltly reduced.
R-ALA clearly not as well studied as metformin in relations to diabetes does seem to offer some improved insuline sensitivity peripherally and has a number of anti-oxidant properties and shows benefits in the treatment of diabetic neuropathies and other types of autonomic dysfunctions.
Metformin can be taken once, twice or three times a day. The usual max dose is 850 mg three times a day.
R-ALA, dosing protocols are not clearly studied but one study tried 600 mg once daily, 600 mg twice daily and 600 mg thrice daily with not difference in outcome (glucose disposal in diabetics).
Good day
AlexH
thanks for the replies guys, but i got some more questions, so i really know what im getting myself into here.
so both are insulin mimetics that partition nutrients away from fat and into muscle, correct?
so can i use metformin the same way i would use k-r-ala? For example? before my Surge shake, and also before a post-workout meal with a lot of carbs? or any meal with a lot of carbs for that matter?
I always enjoy dandalex and BBB’s posts.
so, anyone have any experience with it? What’s the best way to take it? Post-workout? Before large-carb meals? Suggestions? HELP!!!
Insulin sensitizing effects of metformin occur with prolonged use, not acute dosing.
Acute dosing simply inhibits hepatic gluconeogenesis with no impact on insulin sensitivity. Impact on a carb meal shows reduced glucose elevation depending on carb source but no effect on insulin level.
Considering the relatively short plasma half-life and somewhat reduced absorption when taken in with food, metformin should probably be taken three times daily between meals.
For benefits to be derived, this is the type of drug that people need to take regularly for extended periods of time for it to be effective.
AlexH.
[quote]Kamran114 wrote:
I found some of my grandpa’s old diabetes medication in the cupboard. that glucophage stuff.
What does this do with insulin?
What’s the difference between this and glucophase xr (K-R-ALA) that designer supps. sells? Do they essentially do the same thing? When should I take this stuff if I do use it?
Any help greatly appreciated.[/quote]
Dude,
Are you diabetic? If not then why would you ever want to fuck with one of the most vital hormonal systems in your body. You’re playing with dynamite if you start messing with stuff like that, esp with a family history, and all. Learn to manipulate your diet to get the results you’re looking for, and leave grampa’s old medicines in the cupboard.
DJ
[quote]djreef wrote:
Kamran114 wrote:
I found some of my grandpa’s old diabetes medication in the cupboard. that glucophage stuff.
What does this do with insulin?
What’s the difference between this and glucophase xr (K-R-ALA) that designer supps. sells? Do they essentially do the same thing? When should I take this stuff if I do use it?
Any help greatly appreciated.
Dude,
Are you diabetic? If not then why would you ever want to fuck with one of the most vital hormonal systems in your body. You’re playing with dynamite if you start messing with stuff like that, esp with a family history, and all. Learn to manipulate your diet to get the results you’re looking for, and leave grampa’s old medicines in the cupboard.
DJ[/quote]
i don’t think using metformin while being a non-diabetic has that many risks. do you even know what metformin is supposed to do? i went ketogenic for over 9 months. do you know what happened to my insulin sensitivity? my tolerance to carbs became like shit! do you know what that resembles? a diabetic!
even if it wasn’t my special case, i dont think there’s that much risk. all metformin does is dispose of glucose in the blood.
if anything, metformin and glucophage, help make this vital hormonal system work better.
Go read desposo’s article on militant fat loss and metformin on bodybuilding.com
As a 64 yr olde type II diabetic, take it to heart when I say do not screw up your body using this drug. It can cause a very slow developing lifelong problem.
[quote]philipj wrote:
As a 64 yr olde type II diabetic, take it to heart when I say do not screw up your body using this drug. It can cause a very slow developing lifelong problem. [/quote]
Please explain this problem that you refer to. Also, when you say “using this drug”, do you mean at all? Or just abuse? Plz clarify, or somebody help him out. I’m very interested in this, and I’d like to find out what I should be looking for in terms of evidence against the drug, considering so many people on here have used it with positive results.