Low T, New to TRT

Very common.

I would think more common would be the above is worse not better. The day of my injection is trough and serum levels are lowest.

Many have stated feeling best day of injection.

It could be a whole slew of things. Increasing T? Increasing E? Who knows. But it’s common.

Yes day of injection, but this is before I inject. Levels would not be increasing they are decreasing steadily.

@kratom_dumper @highpull @systemlord and to all else… Thyroid labs are back

TSH 0.94 Range (0.40-4.50)
T3 Uptake 33% Range (22-35%)
T4 TOTAL 8.8 mcg/dl Range (4.9-10.5)
Free T4 Index 2.9 Range (1.4-3.8)

From my understanding labs look great. TSH is optimal and T4 is optimal… Can anyone provide insight. Please review my symptoms above. 5 week into TRT and slugglish still. Waiting on labs for Test/e2 still… My fatigue must have been caused by my pre-TRT levels… Still not feeling much different since starting TRT at 50mg every 3.5 days. If anything my libido is worse and overall I feel dull. Less emotions all together… prior to starting TRT I had decent libido but also anxiety. Now both libido and anxiety are gone.

Read this ā€œA somewhat low or high T3 uptake is the presence of a normal TSH level is not clinically relevant.ā€ found this from a published research paper. I was really hoping my Thyroid would be to blame for my persisting issues… I feel like im at a dead end merely existing, I want to enjoy life. I just don’t know what to do anymore and each passing day I lose hope

Starting to think a lot about adrenal fatigue. I have been chronically stressed for a long time… although my fatigue is easily explained by my pre-TRT levels (Free T was 5 ng/dl and TT in the 300s)

I think, generally, 100mg a week is too low. Maybe not if injecting daily, but certainly for twice weekly. I’d go to 75mg every 3.5 days.

These labs tell you almost nothing about your thyroid, like how much thyroid hormone is making it into your cells. Basically the doctor is making the assumption Free T3 is good without actually testing it. Testing Free T3 and Reverse T3 is better because this is the end result, the performance of the thyroid is known, testing T4 and Free T4 and the end result is unknown.

Next time I would test these biomarkers, but TSH looks great.

This is may be disaster waiting to happen.

I agree with this but TSH would be slightly altered right? What would be the cause that my free T4 isn’t making it to T3? Besides RT3

E2 was not tested, but would it be safer to assume that because my T levels were low so was my E2? I am in great shape and lean/muscular… I am really looking forward to receiving my labs here shortly. Also is it possible I require higher TT levels since my pre TRT TT of 380 ng/dl netted me 5ng/dl free T. If this were linear, which I know it is not then I would require 1000ng/dl TT to reach higher Free T levels. Something 100mg weekly would not provide me. Just a thought. What is your input on this?

Below you can see I hold little water

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None of this stuff matter because everyone has different levels of aromatase enzymes within the body and isn’t determine by build. I have seen muscular lean guys aromatase like crazy. I don’t expect your level to be sufficiently elevated until 4-5 weeks provided the dosing is on target, it’s just too earlier in this process.

What I believe happen it you got shutdown at a time when the exogenous testosterone was still low and this is why the symptoms were present.

In your real world experience what are the lab results for 150mg/weekly?

I understand, I just think 5 weeks in now that I should have felt at least something, I am going backwards. I will not change anything until I see my labs. I am not sure why they only posted my Thyroid panel online for me to view… I will call doctors office.

I think this too, first 1-2 weeks I was doing much better energy libido wise.This is why I believe maybe my dosage is too low… Im getting close to steady state

That’s because when you first start TRT, you have your natural production and the exogenous testosterone, so basically for 1-3 weeks you are stacking exogenous testosterone on top of endogenous testosterone.

Right but now my levels are near steady-state exogenous only and I still feel bad. I am at week 5, do you really think one more week is going to change my T levels drastically? Not trying to sound rude, not my intention at all I am seriously just wondering from your experience if week 5 to week 6 changes a lot in regards to T levels.

No I don’t, you could go ahead and do labs now because things won’t change dramatically in another week.

I drew labs up yesterday, im hoping the labs come back on the lower end so at least I have an explanation for my persistent low T symptoms. If thats the case a dosage increase will hopefully fix everything… I will post here once I have the numbers…

It may be, but not everyone is a special snowflake. Odds are greatly in favor of him doing better. Just because a very small minority of guys are overly sensitive to testosterone and estrogen does not mean everyone falls in that box. If you consider hundreds of guys on TRT, most are taking 200mg a week, once a week. Easily, 90% are between 150-200mg and injecting once weekly, or once every two weeks. I know you disagree, but 200mg is not a ā€œmassiveā€ dose of testosterone.

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Very difficult to say. I spoke with a guy this week taking 160mg once weekly, and his total test was 1400 something and free was close to 400, at trough. I take 200mg once weekly and come back at 900-920 total and 200-220 free. Go figure. His E2 was 50 something, about the same as mine. He feels great.