Low T, Low DHEA-S, and High FSH. Possible Causes?

Pharma TRT
1

Hi Guys,

I recently saw my PCP for a follow-up visit after being put on Clomid. My initial labs from June were as follows:

|Testosterone, total|312 ng/dL
250 - 1,100 ng/dL

|Testosterone, free|70.3 pg/mL
35.0 - 155.0 pg/mL

|Estradiol|26 pg/mL
< OR = 39 pg/mL

|Follicle stimulating hormone|10.4 mIU/mL
1.6 - 8.0 mIU/mL

|Luteinizing hormone|6.7 mIU/mL
1.5 - 9.3 mIU/mL

|DHEA sulfate|106 mcg/dL
106 - 464 mcg/dL

I expressed to my doctor that I wanted to increase my testosterone, but didn’t want to go on TRT just yet (36M that would still like to have kids). She suggested Clomid and I started on a dosing schedule of 25MG EOD. Fast forward three months (September) and I just got the following labs back:

|Testosterone, total|224 ng/dL
250 - 1,100 ng/dL*|

|Testosterone, free|65.5 pg/mL
35.0 - 155.0 pg/mL

|Estradiol|29 pg/mL
< OR = 39 pg/mL

|Follicle stimulating hormone|9.8 mIU/mL
1.6 - 8.0 mIU/mL

|Luteinizing hormone|7.2 mIU/mL
1.5 - 9.3 mIU/mL

|DHEA sulfate|47 mcg/dL
106 - 464 mcg/dL

Pretty confused with the results as I thought my T would increase at least a little bit. My DHEA-S also decreased and my FSH is still elevated. Any thoughts on what could cause such a result? I started weight training 3x a week not sure if that affects anything. Not sure if I should increase the clomid dosage and/or supplement with pregnanalone and DHEA. Can these prohormones increase T if I’m deficient?

2

You’ve likely got primary hypogonadism. LH & FSH were high before the Clomid, and that should have been her first clue that a SERM wasn’t gonna work for you. Sadly, most regular docs are still clueless. Anyway, unfortunately, TRT is your answer.

1 Like
3

The results point to testicular failure and you are likely already infertile. As for the low DHEA, it could be damage to the adrenal gland or a diseased pituitary gland.

Do you have any cortisol labs?

Any testicular pain?

I’m afraid you body is incapable of producing certain hormones, you will need to replace the testosterone and supplement the DHEA.

Your PCP is in over his/her head on this matter, you need to see an endocrinologists.