Low or High E2? Libido crash, mood swings, headaches — what would you change?

Pharma / TRT
1

Hey guys, would really appreciate your thoughts on this.

I’m a few weeks into my cycle and everything was going great until about a week ago. Here’s what I’m currently running:

  • Test E 500 mg/week (split Tues/Fri)
  • Primo E 300 mg/week
  • Mast P 200 mg/week
  • Nolvadex 20 mg/day (been using it since the start because I’ve had gyno before)
  • Took one dose of Adex (0.25 mg) three days ago — thought maybe I was getting high E2

For the first few weeks, I felt amazing. Libido was high, mood solid, workouts great. But over the past week things kind of flipped. Now I’m getting:

  • A noticeable drop in libido
  • Feeling weirdly emotional at times
  • Sluggish overall, low motivation
  • Headaches (mainly tension-type, front of the head)
  • Some mild water retention
  • BP has been higher than normal too

I got bloodwork done before taking the Adex, and I’m waiting on the E2 results now. But these symptoms started even before I touched the AI, so now I’m wondering:
Is this high estrogen creeping up, or did Primo, Mast, and Nolva suppress/block estrogen so much that I’m crashing?

If you’ve run something similar, what would you do? Would you drop or reduce Mast, adjust Nolva, or something else?

Any input is really appreciated. Just trying to get back to feeling like myself again.

2

You’re running far too many compounds to guess without lab work.

1 Like
3

It seems you crashed something alright. Go get a full blood panel asap. Then see if you can Get a bp medicine, cholesterol med and a water pill asap.

5

i got a bp medecine already and its already under control.

6

hopefully by tomorrow ill get the E2 lab work, i have already done by cbc and other panels and everything is on point.

7

You did a full panel before or during your cycle?

8

Good job getting that!!

9

before and then at my 5 week mark when things started turning around.

10

And everything on the panel looked good?

11

How different did the panels look?

12

actually most of them look a bit similar, while my ast alt look better since starting the cycle.

13

Just got my E2 sensitive back: 126 pmol/L (ref range: ~29–128).
This result was before I took a 0.25 mg Adex dose (last Thursday).

What’s throwing me off is I was feeling great weeks ago — high libido, clear head, no water. Now things feel off: libido dipped, bit of bloat, and blood pressure started creeping up too.

Would you continue using Adex in this case?
Feels like something shifted, even though bloods look “normal.”

14

Your panel is irrelevant if you took Adex after the panel, what was the point of doing that… you need a new panel

I took adex once and I had the exact same experience. Took weeks to recover. Effing sucks.

I have heard people say great things about Aromasin but I cannot speak to it myself

15

I took the panel before taking any dose to see where my E2 is at before supplementing with adex.

16

But unless I misread this thread, you took your adex before reading the results of your panel. If so, why would you do that.

17

Headaches could have been from increased BP, which could just be from the amount of gear you are using, CNS stimulation. E2 at the top of the range wouldn’t scare me, especially since you are on so much test. obviously you have to go off labs, but if it were me, i would assume my E2 is LOW compared to my test, especially since i think some of the compounds you are taking also lower e2, correct?

Your E2, may be LOW compared to how high your test is.. lay off the adex, completely, in my opinion, see if you start feeling “better” but if you keep feeling bad, maybe lower some of the compounds that lower e2?

High test needs high e2 to feel “dialed in”.

18

This is great advice. So I laid off adex and dropped mast since the past 10 days. Blood pressure is under control now 120/70 on average. Headaches are still present mostly in the afternoons, however manageable now. Planning to do another blood test this coming Thursday, e2, TT, Prolactin and CBC. Don’t feel like stopping the cycle as I’m half way through because of the headaches, hoping the bloods will point me in the right direction.

19

I know headaches are associated with low e2. Could be your case, possibly, obviously no way to tell, but the fact that they are getting better is a good indicator. Good luck.

20

Have you noticed any changes in your erection or sleep in recent days?

21

Hey guys, just wanted to give a quick update and get your thoughts.

Over the past couple of weeks, I was dealing with some pretty bad headaches likely linked to blood pressure and maybe some hormonal fluctuations. Thankfully, things have settled down now: BP is under control, and the headaches are almost completely gone.

As a precaution, I temporarily dropped Mast Prop (200 mg/week) around Week 5 when the headaches and high BP started. Since then, I’ve kept things steady with just Test E (500 mg/week, split 2x/week) and Primo E (300 mg/week, split 3x/week).

I got bloods done on July 3:

  • Total Testosterone: 2300 ng/dL
  • Prolactin: Within normal range
  • E2: Still waiting on results, should be in over the next couple of days

My original plan was:

Run Test E + Primo E + Mast P (to be increased to 300pw) for most of the cycle
Then introduce Anavar (50 mg/day) for the last 6 weeks

Now that things are improving, I’m trying to decide if I should go ahead and reintroduce Mast and follow the originally planned cycle, or to modify it from this point on.

Would really appreciate any input from the vets here. Thanks again to everyone who helped earlier — means a lot.