Gday Guys,
45yr old, navigating through my first 6 months of TRT.
Im on primoteston and pin a split dose every 5 days.
I also have an autoimmune disorder, which was the catalyst for starting TRT, Essentially it shut off my nuts.
Q for feedback, how much of a worry is extremely low HDL? I literally have none.
This is in part due to my AI but may also have some effect from the TRT.
Recent blood work attached for thoughts.
Specialist appointment confirmed in two weeks.
Cheers,
Is this a long term or short term issue you are dealing with?
Why are you on an AI? Why didn’t they test your E2 is you’re on and need an AI? Why are your T levels so high?
Wow you look like a hematologist’s dream. What exactly?
Pre TRT lipid panel?
What is your TRT protocol?
I assume you have had lipid issues way before TRT. Correct?
Hey, yeh I went back as far as I could and results from 2018 are ver close.
So over 5 yrs in my 40s with the same HDL levels there abouts.
I have takem Sirolimus for over a decade for my auto immune which levels off my blood work but killed my hormones 
Hey mate, sorry AI = auto immune in my original post 
My apologies. My mind went to the common forum abbreviation for aromatase inhibitor. Those can lower HDL a good bit.
All good bud, when I read it back, I realised it could easily be misinterpreted
Seems like your autoimmune disease is stressing the liver. Bilirubin is borderline although ASAT/ALAT are on check. Haematology is borderline and might worsen because of TRT. I would decrease Primoteston a little bit to avoid hematopoietic side effects.
Low HDL is long term a cardiovascular risk marker, although your LDL-C seems low, so this is probably a feature of your auto-immune disorder.
I’d expect TRT to cause gradual increase of LDL-C at this dosage.
Non fasted and on a fairly dirty bulk.
Bloods were taken at 430pm and id trained that morning.
Fairly steep increase since September.
“The results of this study indicate that testosterone replacement therapy in hypogonadal and elderly men may have a beneficial effect on lipid metabolism through decreasing total cholesterol and atherogenic fraction of LDL-cholesterol without significant alterations in HDL-cholesterol levels or its subfractions HDL2-C and HDL3-C.”
Mitigated results here…LDL-c is stable, but TG is not good, especially with such a low HDL-c… this is quite atherogenic. Are you planning to reduce dosage? Or at least adjust your dietary intake?
Also forgot to ask, your autoimmune disease, is it identified and under control? Seems to interfere with your lipid metabolism even before TRT.
Hey Miosie. Short answer is yes (but) sirolimus my drug used to treat it, is pretty strong too. In fact I wonder if they’re fighting against the testosterone as there is something mTor related, ive lost the article now.
Ive come down to .35ml (87.5mg) every 3 or so days now.
I know the cholesterol impact from sirolimus is pretty common so I haven’t really worried about it.
I think the Tris are high based on me having the bloods taken late in the day and Id eaten a good bag of pork crackling for a snack that lunch.
Really need a follow up test I guess
Cheers
Alright! That’d be good if you can have a fasted test and start weighing the pro’s and con’s of controlling lipids…
