I have a pituitary tumor, diagnosed in 2018. Been on TRT since 2019. On thyroid meds, and cortisol is ok. I’ve been taking HGH .4 once a day for 2 months roughly. Its killing my libido, and I dont understand why. I took HGH a year ago, and the same thing happen, and I stopped and my libido came back. I actually need the HGH, cause I failed a stim test, and my endocrinologist prescribed me Genotropin. Prolactin is normal, and I even took some cabergoline anyway, just to see if it helped. I also tried a AI, small dosage ,25 Anastrazole, and nothing helped. I cant understand why HGH does this to me, and when I stop it, my libido comes back.
Estrogen is at 30 ultrasensitive
Testosterone is at a 920
No recent labs on Free test or SBHG but these are always in range, including the last time I had this problem.
Free T4 is 1.5
Free T3 is 4.1
TSH is non irrelevant in my case
I found an article that may or may not be helpful in further dissecting exactly where your problem may lie:
Results: Only severe hyperprolactinemia (>35 ng/mL or 735 mU/L), often related to a pituitary tumor, has a negative impact on sexual function, impairing sexual desire, testosterone production, and, through the latter, erectile function due to a dual effect: mass effect and PRL-induced suppression on gonadotropin secretion. The latter is PRL-level dependent. Emerging evidence indicates that hyperthyroidism is associated with an increased risk of premature ejaculation and might also be associated with erectile dysfunction (ED), whereas hypothyroidism mainly affects sexual desire and impairs the ejaculatory reflex. However, the real incidence of thyroid dysfunction in subjects with sexual problems needs to be evaluated. Prevalence of ED and decreased libido increase in acromegalic patients; however, it is still a matter of debate whether GH excess (acromegaly) may create effects due to a direct overproduction of GH/insulin-like growth factor 1 or because of the pituitary mass effects on gonadotropic cells, resulting in hypogonadism.