I´m also sceptical despite lowering trt dose, i still don´t feel confortable with Prolactin over 10, which i had with a microdose of Arimidex, since i quit AI prolactin is always over 15, reaching 18, i pin EOD, even ED it did not lower it.
Next step for me will be to reintroduced a very low dose Arimidex and test again after a while and see, i´ll update my thread with today´s result
That is 90 mg splited EOD, shallow IM on shoulders
@zsub154 find my email in my bio and email me.
@lukedorian there are ways to reduce prolactin without taking an AI. You don’t block estradiol to try to lower prolactin. It is most definitely one of those things that will cause issues past a certain point. Have you looked into P5P? It is as effective as cabergoline. There are several papers on the subject if you do an online search.
Call me skeptical on that one. Can you post those papers?
It does not convert to E2 but rather 7a-methyl estradiol so don’t expect to see an E2 in the 50s.
The only normal prolactin reading I’ve ever had was after taking P5P for a while. I know n=1 isn’t exactly a scientific study, but it did seem to work for me. Prior to that mine had gone from 20 to 30 to 40’s over about a 2 year period
Do a google search for ‘p5p versus cabergoline’. Click on the first result from Researchgate. Then click on ‘Download full-text PDF’.
1 Like
Recommended p5p dose for guys with high end of prolactin still in the reference range?
Start with 50mg a day and do that for a few weeks. You can go as high as 200mg. Work your way up slowly and find a dose that makes you feel your best.
Hello thanks for the reply there Danny, thing is if you look at this thread i post all recent labs and protocol changes
There you can clearly see that on 11/02/2020, microdosing Arimidex is when more stable prolactin and E2 are, i don´t remember how i felt tho, now like i´m making record of all this i´ll check it out.
There i was taking 0.025 mg and yes you already said that them doses are just too low and i should not notice anything on that dose but as you see it does makes a difference
I already feel awful on Vitamins i get insomnia almost instantly, reading that p5p is vitamin B6.
I would focus on getting prolactin down directly versus bringing down estradiol if I was in this situation. I’d start 50mg daily P5P and give it a few weeks then bump up to 100mg if required and do that for a few weeks up to 200mg. I’d simply find the dose that makes me feel my best. The issue isn’t estradiol. My E2 is 50% higher than yours and, no, I’m not using an AI. However my prolactin has ALWAYS been above the range, even prior to TRT when my E2 was 12. Zinc, vitamin e, p5p, b6 etc… all help to bring prolactin down with p5p being the best of the bunch.
I agree, E2 does not bother me, how ever it is well known that prolactin tends to go up when E2 is out of control so i´m guessing i havce to address E2 in order to control prolactin.
One other thing i take finasteride 3 times a week, a very small dose only 0.125 mg, so that also might be a factor to have higher E3 hence higher prolactin.
About Frequency of injection EOD is the same as ED but way better than twice per week in my case.
or you could, ya know, try P5P like has been stated 3x now
1 Like
It converts to a more powerful estradiol and I’m taking significantly more than an equivalent dose of testosterone. I’m willing to bet that the amount of methyl-estradiol is far higher relative to what my normal E2 reading would be on traditional trt. I am deeply confused as to what argument you’re trying to make here.
I keep giving you the best advice I can possibly give you but you keep insisting you need to control E2.
Forget about E2. I had the same issue as you. I focused on lowering prolactin. I don’t touch E2. I gave you potential solutions to lower prolactin. Stop worrying about E2. You aren’t ‘high’ by any stretch of the imagination. Finasteride messes up a lot of guys and that’s the first thing I would consider cutting out before anything else.
EOD means every other day (every second day). Divide your weekly dose by 3.5 and inject that amount every other day.
ED means every day. Divide your weekly dose by 7 and inject that amount every day.
I meant labs did not vary from EOD to ED, they where the same but better than twice per week
Only that you shouldn’t expect to see an “E2 reading in the 50s”. Didn’t want you to be surprised by a non-existent number there.
Also, would you mind giving an update on your Trest only protocol? I’m nicely dialed in on 60mg of T a week but wouldn’t mind giving Trest a run. I’m considering running it at 2.5mg EOD.
Yeah but what about E2? 
Ok, I see where you’re coming from now. Yes, the actual reading that would pop up would be potentially misleading. Given that methyl-estradiol has the same affinity for the ER as regular old estradiol my assumption is that the sensitive assay test would read it as such. But of course I don’t know that for sure!
I’ve read on other forums that it doesn’t show but am looking forward to seeing your bloodwork.