Is REZ-V Effective?

An excerpt from a study:

[b]Johan Auwerx (at the Institute of Genetics and Molecular and Cell Biology in Illkirch, France) and coauthors published an online article in the journal CELL in November 2006. Mice fed resveratrol for 15 weeks had better treadmill endurance than controls. The study supported Sinclair’s hypothesis that the effects of resveratrol are indeed due to the activation of SIRT1.

Nicholas Wade’s interview-article with Dr. Auwerx[33] states that the dose was 400 mg/kg of body weight (much higher than the 22 mg/kg of the Sinclair study). For an 80 kg (176 lb) person, the 400 mg/kg of body weight amount used in Dr. Auwerx’s mouse study would come to 32,000 mg/day.

Compensating for the fact that humans have slower metabolic rates than mice would change the equivalent human dose to roughly 4571 mg/day. Again, there is no published evidence anywhere in the scientific literature of any clinical trial for efficacy in humans. There is limited human safety data (see above). It is premature to take resveratrol and expect any particular results. Long-term safety has not been evaluated in humans.[/b]

The REZ-V supplement Biotest sells contains only 600 mg resveratrol/serving. The above study indicates that a human of 180 pounds with an average metabolism requires close to 5,000 mg/day of resveratrol for an impact to occur on performance.

Thoughts?

EDIT: Nevermind…

[quote]BluePfaltz wrote:
where the hell is Cy these days… [/quote]

?

“Mice fed resveratrol for 15 weeks had better treadmill endurance than controls.”

Sure, to improve endurance capacity it may take that high of a dose, but there are so many benefits beyond cardio/endurance to resveratrol.

It’s not a “one dose for all” type of deal.

Ready anything scientific and you’re smacked by the numerous studies.

[quote]SBT wrote:
“Mice fed resveratrol for 15 weeks had better treadmill endurance than controls.”

Sure, to improve endurance capacity it may take that high of a dose, but there are so many benefits beyond cardio/endurance to resveratrol.

It’s not a “one dose for all” type of deal.

Ready anything scientific and you’re smacked by the numerous studies.[/quote]

could you please elaborate

[quote]Seinix wrote:
The REZ-V supplement Biotest sells contains only 600 mg resveratrol/serving. The above study indicates that a human of 180 pounds with an average metabolism requires close to 5,000 mg/day of resveratrol for an impact to occur on performance.

Thoughts?[/quote]

I don’t recall anyone claiming they took REZ-V to improve endurance. From my understanding, that’s not what it’s designed to do.

Check out http://www.T-Nation.com/readArticle.do?id=1158493.

[quote]HK24719 wrote:
Seinix wrote:
The REZ-V supplement Biotest sells contains only 600 mg resveratrol/serving. The above study indicates that a human of 180 pounds with an average metabolism requires close to 5,000 mg/day of resveratrol for an impact to occur on performance.

Thoughts?

I don’t recall anyone claiming they took REZ-V to improve endurance. From my understanding, that’s not what it’s designed to do.

Check out http://www.T-Nation.com/readArticle.do?id=1158493. [/quote]

MORE GOOD STUFF

While athletes should no doubt be excited about these Testosterone-increasing, estrogen-lowering effects of resveratrol, male and female Life Extension people have been all over this substance for other reasons.

An overwhelming amount of literature on resveratrol has demonstrated potent cardiovascular benefits, anti-aging effects, powerful anti-cancer effects, anti-arthritic, and neurological effects (e.g. potential benefits in treating Alzheimer’s Disease). Many of these benefits seem to stem from anti-oxidative and anti-inflammatory effects as well as gene modulation. (13-21)

What the Life Extension people are most excited about, though, is that resveratrol might actually extend lifespan.

Remember those calorie deprivation people that believed you could extend your lifespan considerably by just munching on a ridiculously low number of calories each day?

Well, one proposed mechanism by which calorie deprivation can make you live longer is that it activates a protein called SIRT1 (sirtuin 1). Activation of this protein inhibits PPAR-gamma activity and this causes your body to burn fat.

It’s not hard to imagine that having less fat might cause you to live longer, but remarkably, resveratrol activates this very same SIRT1 protein.

So even if you’re not concerned with extending your life at this point, resveratrol can cause your body to burn fat.

Maybe you’ve heard of the “French Paradox” (and no, it has nothing to do with why their star soccer player would head butt a guy in the finals of the World Cup)?

It’s the medical puzzle where certain populations (French and Greek) seem to experience a low incidence of coronary heart disease while eating a diet high in saturated fat. Epidemiologists have reasoned that it has to do with their daily consumption of red wine.

Well, many researchers have gone one step further and concluded that it was the resveratrol in the wine that was responsible for the French Paradox. (22-25)

This miracle substance has also been shown to have impressive anti-fungal and anti-viral properties, and may even protect the liver from excessive alcohol consumption or oxidative damage from taking too much acetaminophen. (26-39)

If all that wasn’t enough, there’s a good deal of data demonstrating that resveratrol is an extremely promising compound for the prevention and treatment of prostate cancer! (40-48)

So if taking Testosterone-boosting supplements has made you wary before because of possible prostate risks, resveratrol seems like the answer to your prayers.


Please read the above bold sections. These benefits rely on the activation SIRT1 protein, which was the same protein whose activation was observed in the experiment in my first post. Therefore, resveratrol activates the SIRT1 protein, yielding all these beneficial effects. However, if the resveratrol supplementation in the Biotest REZ-V is insufficient, and consequently the SIRT1 protein is not activated/not activated enough, then is REZ-V really effective?