Spending more time with the LEF article, the herb is looking quite interesting.
Not even considering fat loss, the reported changes in LDL, HDL, and C-reactive protein are very impressive and could easily represent very significant health benefit.
I’d have to characterize the LEF article as being flawed by what I call the Marcia Clark method of presenting a case.
In this method, instead of sticking to one really clear, conclusive point or with a very few completely sound points that can’t be refuted, one thinks that presenting a vast number of points is better. It’s not.
And furthermore, to really be a Marcia Clark, at least one of these points has to be dubious. This has the result of the person trying to follow the argument wondering if maybe all the points are dubious.
It could also be called the “bedazzling with bullshit” method of presenting a case. It’s not the way to go.
My estimate at this point is that most of the claimed mechanisms have nothing to do with anything. For example claiming it as an amylase inhibitor. Maybe such an effect can be detected but I doubt it has the slightest trace of relevance.
And also as mentioned I just do not believe people lost 28 lb in 10 weeks with no change in diet or exercise. No change in instructed diet I believe, but no change in actual diet, I do not. There is no reason to believe that the herb increases energy expenditure so dramatically.
However, if the body is triggered to release and not re-uptake into adipose tissue a large amount of fat, then this supplies energy that no longer is needed from the diet. If the person feels correspondingly less hungry and eats correspondingly less, then sure the weight loss is possible.
It seems most likely the truly causative effect on fat loss is the effect on adiponectin.
If I were editing the article – fat chance I’d be chosen for such a job! – I’d have boiled down the claimed fat loss results to the measured change in adiponectin, brought in the discussion on leptin, admitted more clearly in the text that the article was unpublished and the subjects had metabolic syndrome and therefore more study should be done with the normal population; and brought in the effects on blood lipids as a further likely health benefit.
That would have been really solid I think, instead of all over the map and with questionable points.
Sometimes focus makes things clearer. (Uh, a lot of the time it does.)