I would recommend smaller more frequent doses, it would help to know your other pre-TRT lab values, like SHBG and estrogen. I’ve had a little bit of anxiety on just about every protocol I’ve been on except one, when I was doing a 10mg daily protocol I didn’t have any anxiety.
That has to do with the fact that being on a daily protocol the peaks and troughs are tiny, the larger peaks and troughs may be what’s causing your anxiety. TRT could also be depleting pregnenolone and or magnesium, deficient in either one of these could cause anxiety.
Benzodiazepines, I know them all too well and was on them for 30 years and is why I need TRT for life.
Did you recently just stopped a benzodiazepine? I did a 10 months slow taper and at the end I needed TRT where before my testosterone was perfectly fine.
It could also be that you over responded to the anastrozole which would explain the anxiety and muscle pain that you did not experience years earlier.
You have the advantage for the fact that you’re working with Defy Medical, I’m a patient as well.