One reason is because I have low SHBG, 14 as of yesterday. There are some regardless of SHBG levels are very sensitive to fluctuations and excounter negative symptoms when levels are declining for too long, others don’t notice the decline as much.
These TRT clinics are limiting who they treat by putting everyone on a cookie cutter protocol designed for everyone, guys will low SHBG are more than likely going to quit and go elsewhere.
These clinic will make excuses as to why you can’t take the prescription vials home, that it a controlled substance, cialis and antidepressants is a controlled substance and yet you don’t see men going to the doctors office daily for their pill.
Another excuse is you risk infection, children are taught to self inject insulin at home. If a nurse can learn to inject patients, than patients can learn to self inject as well.
Cutting through all the BS, they just want to charge a fee for the injection and keep you coming back for more opportunities for more services, after all it’s a business.
I do have high SHBG, but I will do EOD injections anyways
Trust and decipher bro science from real science. What the body needs versus what the bro science says it doesn’t.
Thanks. From twice a week injections total 200mg, I will do 50 EOD
What do you think about HCG?. Do you think is necessary for wellbeing?
If you did one a week shots and felt great why would you go to a forum. The forum is where folks that don’t feel great and are looking for answers go. I’m sure a large majority of people on TRT are doing once a week and are good enough not to look for better.
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I guess we are the unlucky ones lol
High SHBG comes down over time with high normal androgen levels. Bigger less frequent injections are usually recommended so that you get freeT, the smaller injections tend to allow the SHBG to bind most of it. Long term, it won’t matter, short term you may feel better at least in bursts with bigger injections. Do the thing that works for you though, not what works for someone else.
I WISH 100mg had me peak at 900ng/dl
No it’s not. It’s good for fertility. For some of us when we have low sensitivity in the penis it seems HCG helps because it increases estrogen aromatization in the penis. I was experiencing this (not all men do) and after reading a study / article on estrogen posted by Dr. Jordan Grant I realized that maybe my body is not aromatizing estrogen in that area.
The study says that the body creates e in the bones brain heart muscles skin and penis and etc… therefore blood serum estrogen is not a good gauge because it cannot tell you how much e2 is in the heart. That’s why we say don’t use ai. You could be torturing your brain and that’s why guys have anxiety or high blood pressure because hearts low on e2.
Anyways I tried it and it works every time. I stop for a couple weeks and try again and it works. I take 150iu every 4days. I have tried so many times and it works every time.
I have tried more free t and that never helps with sensitivity. For whatever reason I just don’t create much estrogen in that area and I believe this is why I have that issue.
This is all based on my experience. The study backs up my thoughts but I cannot guarantee this is truly what’s causing sensiviry.
For most men this is not the case.
What I learned from the forums and a few guys I know personally is that TRT works SLOWLY. Not with everyone, but most people. Every change you need to give it enough time, at lest 6 weeks seems with some people takes even longer. The body may need enough time to get used to the testosterone levels, to estrogen levels, to balance HCT or whatever.
The single certain recipe to failure seems to be often changing things.
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Shbg should not dictate injection frequency.
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@charlie12 I’ve heard this being said only by doctors who recommend daily injections anyway…
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So many low SHBG men report feeling better on more frequent dosing, this is also the position of my doctor (an endo/cardiologist) who is more experienced than most doctors are on the subject of hormone replacement.
Low SHBG men don’t need high normal levels, in fact they usually do best about midrange TT which will see FT levels near or above the top of the ranges and the only way to keep levels in those ranges if very frequent dosing, or else levels will decline rapidly if injections are spaced out to much.
Also TT and FT ratios are greater and any decline of TT will see FT levels affected by a larger degree then increasing symptomatology. I see low SHBG men struggle more often because the injection frequency is inappropriate which causes excess testosterone, estrogen and therefore symptoms.
Exactly. I read a study from NCBI a while ago that indicated that E2 doesn’t travel well. The indication was that we have enzyme everywhere and the test travels freely to be used where needed. So guys using the AI and HCG are really liable to just shut down E2 everywhere but the scrotum, which I expect would be problematic. I don’t know why people run to start multiple things at once. one thing at a time, and take as few things as possible. Every new drug or supplement is just an extra variable to complicate things. I still won’t say no AI ever, but I’m sticking with use it only if you need it and as little as possible if you do.
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Isnt low SHBG being increased with improving insulin sensitivity?
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Are you aware of any research on this? it would be interesting. While I know some guys with low SHBG who do need twice a week injections, it certainly is not all and many do well with one. I know some with high SHBG who also do better with twice weekly dosing, not many, but some.
Research no, just by the shear numbers of low SHBG men across multiple forums I believe this represents the majority, but I will admit there are low SHBG men who even do fine on weekly dosing, it seems less common at least on the forums.
When I did weekly dosing after 15 weeks I started noticing a crash, twice weekly there was a slight crash on the third day which is strange considering my trough levels were 697, FT 29 pg/mL, not low by any standards.
If levels deline for too long, I feel this decline.
And only use it for a short while for the rarest of cases. Not simply because your nipples are itchy or you have a little water retention.
A guy was on excel male Facebook group yesterday. He posted he has an e2
Of 20-23 over the last 3-4 years. He wanted
To know why he’s peeing all the time. He thinks his prostate is bunked. All types of issues and he thinks estrogen causes prostate problems.
The guy could simply stop the ai and his symptoms would resolve.
He kinda listened.
I explained on low t before trt I had night sweats every night and the exact same symptoms with the exact same excessive urinating. It all disappeared with my first shot
Of T.
How you been man? How is the frequency and dose increase treating you?
How has the thyroid meds been treating you?
Interested to hear how things are going @roscoe88.