I have a question that perhaps someone, could help me with. As I understand it, estradiol’s half life is 13-17 hours. Does that mean that in approximately 13-17 hours my E2 blood level of a theoretical 72, would be / 2 = 36. and then / 2 =18 in a total of 34 hours?
Please note the above is an example only so I can better understand half life as it pertains to estradiol. (no lab information is necessary)
Thank you for your help!
Thom
Yes, approximately.
If its related to exogenous T maybe this helps. T and E2 go hand in hand.
Thank you and it does help. I have always had a problem managing my E2, I guess I’m not alone on that one. I know with me a small amount of AI can drive me straight down to the bottom, it’s horrible. I “think” my max dose is 10% of 1mg tablet, so I’m trying to figure out how to dose it without crashing. Presently, I lowered my dose to .40mg E3D of TC.100mg weekly which I “think” is where I need to be, since I was high on E2 with .70, and .50 so now it’s .40mg TC. The last time i was on a .40mg I was near perfect with TT 1120, FT 34.8 and E2 34.8. But I was interested in trying higher doses, since many of the guys I know, are all around 200mg weekly and some even higher, and the’re happy, and some are using zero AI. But for me those doses were driving up my E2 over 70 so I’m re starting .40mg E3D and I may need a little AI so I just want to learn how to think about how to dose it.
Were you having lingering issues with your E being where it was? Most people are fine after a few weeks, no AI needed.
Hello,
Thanks for your response. I’m not sure if I can agree about “most” people. In my case I may not be clearing out E2 efficiently, which I don’t know one way, or the other. I know I’m ok at E2 at 40-50 max. I also know that I have the same TT FT at .20ml vs. .35ml except at .35ml I have a 72 E2 Sen. Ans at .20 I have E2 Sen at 36.
As you can see I’m still learning, but I know enough that AI’s are still being used in a very large number.
Thank you again!
Thom
@Thomtst
What were the problems you were having?
Try taking some Zinc and Boron. It helps lower Estradiol
Yes. Thank you also Christin, and Nettles herbs.
Thanks again for the response. As you may have suspected I’m trying to figure out how to manage my E2. I “think” I do better on TRT with higher levels of T perhaps about 70 +mg weekly. However, at that dose I get very high E2 levels about 80+. In the past, I made the mistake of wrongly thinking that anastrozole would lower E2, so I took the AI after the T injection. That’s a little like closing the barn door, after the horse already ran away. Presently, I’ve started fresh dosing 40mg TC weekly E3D and I’ll slowly move my dose higher until I hit my sweet spot. I was concerned about rising E2 and AI masking my sweet spot which is why I asked my original question. You seem very knowledgeable, so I thought I would share my of my challenge in greater detail wondering if you had any additional advice. Frankly, my doctor is all about the money. You set an appointment pay him $75.00 you geet about 7-10 minutes and he’s gone. Needless to say he’s useless, except I can get my meds hassle free. This is doc number 4. Anyway, if you have a thought or two about my challenge, I would welcome your response.
Thanks again.
Thom
Hi Tom,
Unfortunately I don’t have any personal experience regarding the use of AI. I try to stay away from AIs as every drug has its (maybe long term unknown) side effects. For me less is more in this regard and I rather have lower T and acceptable E2 than higher T and the need for an AI.
Actually I am also surprised how many members use >150mg per week of T and still their E2 is <50.
At least for me it looks like as if I have a relatively fixed T:E2 ratio, independent of the T amount I use.
The only recommendation that I could give is to try what many here advocate: smaller more frequent injections and see how it develops.
Thank you I appreciate your advice.
Have a great day!