I am curious about the cycle of E in relation to TRT injections. Like most patients I take my Anastrozole once weekly the day after my injection. But my recent labs came back with highish E (41.5) and I’m not keen on my overall performance at this level (I like mine around 20-30). Even though my free T was 21 and total was 800+. I’m only taking 1/4 pill of Anastrozole, but doc doesn’t want me moving up to a 1/2 for concern of crashing my E.
Here’s the question. I inject Wednesday morning. Anastrozole Thursday morning. Every Saturday, without fail for 9 months, I get acne on my left temple. I’m wondering if this symptom and timing clues anyone in as to when exactly the E spike is happening, the metabolization of my T shot, and if changing the time of my AI will yield better results.
The timing is wrong, by the time estrogen is peaking the AI hasn’t reach maximum effectiveness. Sounds like your doctors is afraid to do what’s expected, raise the AI dosage. Whenever I see a doctor tuck his tail between his legs I lose respect for him.
We always tell folks to take the AI at the time of the injection, by the time estrogen peaks the AI will already be at maximum effectiveness.
A legitimate concern, however you noted symptoms (“not keen on my overall performance”) coincidental with higher E2 levels. I would take my anastrozole Wednesday night and take a second weekly dose on Sunday morning.
Same day you say? That’s curious. That’s the one piece of advice I haven’t seen yet. I’m not aware of how quickly the AI works, and how long it lasts, vs, the peak T absorption after shot, etc. Interesting. I am considering splitting my 160 does into to shots every 4 days now though.
I’m going to give this advice a try. I’m also going to begin splitting my shot into twice weekly 80 doses instead of the single 170. Problem is I’ll run out of AI early and have to tell the doc what I decided to do on my own to get the script refilled…
Half life of anastrozole is 46-48 hours. Gets in pretty quickly. Some guys take it at the time of injection and some 24 hours later. Some micro dose daily. TRT guys (myself included) are probably overthinking it a bit.
Personally, I have taken it at the time of, the next day, and twelve hours after injection, which is what I do currently. Not sure if I can appreciate any difference, but I’m doing well. We all respond differently, the trial and error approach, provided it’s reasonable, will eventually get you where you want to be.
I will agree with this.
The timing of when you take your Arimidex(anastrozole) (Half life 2 days) - Steady state is 10 days.
After 5 half lives of any medication, you will have double the amount in your system. Just multiply the half life of a medication by 5, and this will give you how long it will take to reach a “steady state” of a medication a.k.a double the amount of that medication in your system compared to your first dose. For example, half life of Arimidex is 2 days. So 5x2 equals 10. So on the 10th day of taking Arimidex regularly, you will have reached the steady state of the Arimidex in your system.
Dynabro can you not get your prescription from a compounding pharmacy in micro doses like .125mg/pill? That is the best way to do it. trying to cut 1mg womens cancer pills into 4 pieces sucks big time.
Suggest that you split T and inject twice a week to get steadier levels. Subq is steadier than IM and you can use #29 1/2" [12mm] 0.5ml insulin syringes for IM or subq.
Take anastrozole at time of injections for simplicity. You need to take more. Most need 1mg anastrozole per 100mg injected T. A few are over-responders who need 1/4th of the expected amounts and that could spook a doc who has no knowledge about this. No way to know in advance.
Anastrozole is competitive to T at aromatase reaction sites and needs to match steady serum T levels. T–>E2 rates are proportional to T levels.
Expect to feel a major improvement in 7 days: libido, energy, mood, tolerance and socialization.
Slightly confused. Let’s see if I even ask the right question! So you’re saying that double weekly doses of 0.25 will result in a steady level? And that’s good for me?
Based on splitting my weekly 160 shot into 2 80s AND taking the 0.25 AI with each injection innday of? Just making sure I’m on the same page. And yes, I definitely will look into microcode options. Solid advice.
Spitting your T dose in two will likely help to lower your E2 as well. If you plan to split the T anyways I’d try that first before adding more anastrazole into the mix. Just my 2 cents.
I take my AI the day after my shot. I believe everyone is different though and labs are the only way to tell what is better for you. Taking day of the shot had my E at 33, and taken the day after my shot put me at 22. No other changes were made.
Sure. Which is why I’m presenting the continual Wednesday injection, Thursday AI, Saturday zits and greasy faced schedule. My hope was that schedule revealed something about my metabolic rate of the T and would lead to a recommended dosage time for the AI.
Let me guess you are some where between the age of 20-35? Greasy skin and acne is the price one pays to play the TRT game so young. I think you will find it is not all E2 related. Checkout some of Noah’s vids.
Oily skin and ache is from excess DHT which happens when you convert a lot of testosterone into DHT. Lowering your test dosage is the only sane way to lessen oily skin and ache. Do not take drugs to lower DHT, your asking for it.
Elevated test, and sub sequentially, elevated E2, is gonna cause some acne. I don’t think age has anything to do with it though.
DHT causes the oiliness, which can contribute to acne, but I was always under the impression that acne is caused by e2 being high.
At least for me, its one of my tells that my e2 is high.
If I have a greasy forehead, but am avoiding acne, I know im right where I should be.
When I was 18-19, I had high test, and I also had greasy skin and acne. Seems like it would be normal to experience the same thing when test is artificially elevated by TRT.
I like that guy. But this video is worthless. There are also a few other videos where I don’t know if the information is the best. The blood pressure video is one.
He didn’t give us any values, any idea where his numbers are falling.
He just said, I lowered my dose from 200 to 160 and I still have acne!!! (no TT, FT, E2,)
It was a friendly heads up, you’ve had an attitude since day one. I’ve tried to be diplomatic with you to no avail. Your response shows your state of mind is largely negative, my attitude largely positive.
Thought I would save you the trouble of having a mod message you, I’ve made similar mistakes myself and thought I would save you the trouble. Next I’ll just let it happen on it’s own.
