Will reply when I have access to computer again
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Grew up in Mississippi and had a very similar experience. Itās amazing what that stuff can do to make you see major needed life changes and wake the F up to whatās going on. Love it
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HaHa well at least you have an excuse.
Me its just fat fingering on one too many wild turkeys 101.
ahhhā¦good taste sir, good taste
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Alright sir, so androgen induced water retention can be induced through various mechanisms. E2 may be one mechanism behind androgen induced water retention, however androgens, esp at high doses may induced dysregulation of the renal angiotensin aldosterone system, of which regulates water retention. Vascular remodelling, furthermore 11b HSD2 inhibition induced by anabolic steroids may lead to increased sodium retention and bloating. 11bHSD is a family of enzymes primary responsible for the conversion of cortisone to cortisol and vice verca. Inhibition of 11b HSD2. Within aldosterone selective tissues, said enzyme (11bHSD2) is responsible for the oxidation of cortisol into less potent metabolite cortisone. Inhibition of said enzyme will lead to less conversion, and it should be noted cortisone has far weaker glucocorticoid activity compared to cortisone. However this is marginally irrelevant when it comes to the fact of which androgens tend to reduce cortisol, however testosterone, DHT and estradiol have a weak binding affinity to CBG, yet this is likely somewhat irrelevant.
Aside from E2 (and potentially a role within 11hsd2 inhibition, Iād hypothesise a large portion of water retention induced by testosterone may be mediated via prohypertensive effects and/or remodelling involving the RAAS system. Furthermore diet can have a large impact on water retention when using compounds of which can greatly alter the way one takes in nutrients and the biological response to said nutrients. Furthermore impaired hepatic function will limit clearance of excess oestrogen
Lowering E2 in general is a bad idea, itās complicated, however aside from the effects regarding glucose, lipids, endothelial function, neurotransmitters, interfering with the bodies natural balance (aside from the fact the additional E2 and test is pharmacologically added and supraphysiologic in nature) can end up screwing with ratios of subtypes of oestrogen, the body is quite smart at holding onto what it needs.
If absolutely required one could use an AI, esp if itās cycle related and not simply TRT, however Iād hold off if I could. If one canāt use testosterone at supra doses without issues such as HBP, extreme bloating etc, potentially test isnāt for them and an alternate compound could be used. Blasting isnāt healthy by any means regardless, thus either way youāre going to be causing damage. Perhaps a dry compound may suit you better (or not, stronger androgens and non aromatising androgens tend to have a higher risk regarding cardiovascular pathology, esp for older individuals, thus atherosclerosis, androgenicity (prostate) and myocardial infarction may be a serious concern with drugs like drostanolone, metenolone etc)
Thanks unreal, I really appreciate your time and sharing your thoughts on my issue.
I donāt add sodium but I am sure there is added sodium in several foods I eat during the day. Deli ham, turkey, smoked salmon.
Out of 5 blasts over the last 3 years(4 successful 1 ended early do to high HCT/low ferritin issue) this was the largest dose 380mg/w but also the first time my E2 has not returned to the high 20ās where I feel best.
My current lipid panel is better than it has ever been. When I started this journey everything but HDL was over range and in the red. My triglycerides were over 300.
I have some Mastobal (masteron) on order and will be adding 200mg/wk for a test. I am hoping this will help me dryout and correct my ED issue. Current libido is perfect I just canāt keep my dick hard.
What are youāre trigs currently? 300 is a concern dude, furthermore if you add 200mg mast youāre on 580mg/wk (or are you on 400mg/wk now, in which case itās 600mg/wk).
How long do you intend to run this blast for? If current libido is perfect, yet ED is an issue one could opt for a pde5 inhibitor (Iām no doctor and thus donāt recommend medications, however in theory itās a hell of a lot safer)
Iām off the blast. I started my Spring blast March 1st 120mg x3/wk 1000iu HCG/wk no AI for now anastrozole if needed. I usually let my E2 run unless side get unbearable.
Cardarine 20mg 5 days a week only on gym days. 500mcg Ipamorelin nightly.
If you scroll up you will see a post where I just posted my current bloods and brought this 5 month old post back. my lipid panel is awesome. My problem is 5 months later my E2 has not returned to the high 20s where it always does on my TRT protocol plus I have developed extreme ED and am still holding water.
(I replied via email)
Also, Franco Columbu died today, Iām spreading the word.
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So sad to hear about Franco.
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