High Free T and Low Free T Direct

Hello,

I’ve been lurking here for a while.

I have had a variety of “low-T” type symptoms for many years now. I am now a 29 year old male. Here are some of my symptoms:

Feel little or no pleasure from sex.
Seldom have morning erections.
Brain Fog.
Tired and irritable in spite of ample sleep at night.
Results from workouts not what I expect.
I became interested in girls years later than my peers. (or so I think)

I’ve had well-meaning people try to “talk me out of it” and convince me that it’s “all in my head”. Bullshit, I know better than that!

My symptoms began around age 20. I’ve seen a number of doctors, most of whom were not the least bit helpful.

One doctor whom I saw suggested that I could have a case of chronic Lyme Disease. Reading about Lyme Disease, I was rather skeptical, but I tried the herbal regimen he recommended and I reported about a 40% reduction in the severity of my symptoms. At first, it seemed like a miracle-cure, but even as I was feeling better, my improvement stopped, and I knew something was still wrong.

My previous lab work included testosterone, but the diagnosing physician didn’t work with t-replacement. However, he did suggest that chronic disease organisms can disrupt the body’s ability to maintain healthy hormone levels. I thought about that, but I can’t help but wonder if that has something to do with my becoming interested in girls at a later age.

Anyways, here are some of the highlights from the last time the above doctor had my blood drawn (by Labcorp). (Apr 2, 2012)

WBC 3.1 1000/ micL (4.0 - 10.5) (has been low for years)
Total T 476 ng/dL (348 - 1197) (same as a test done 2 years ago)
T, Free Direct 9.5 pg/mL (9.3 - 26.5) (about the same as a test done 2 years ago)
SHBG 29.7 nmol/L (16.5 - 55.9)
LH 3.4 mIU/mL (1.7 - 8.6)

I decided to try something different. I found my way to a physician who specializes in bioidentical hormone replacement therapy. She insisted on ordering blood work again. Here are the highlights:

WBC 3.1 1000/micL (4.0 - 10.5)
Total T 513 ng/dL (348 - 1197)
T, Free 34.73 ng/dL (5.0 - 21.0)

The physician said that based on her previous one hour consultation with me, it sounded like low-T, but with the new test results say high-T!

She (the physician) pointed out the following. I am taking a number of supplements; she supposed that recently changing from one brand to another might have caused an anomalous result (I doubt it) (My supplements: adrenal glandular, Japanese Knotweed (Resveratrol), Stephania Tetrandra, Andrographis, Cat’s Claw). The other thing is that her test that says I have high-T is “Free Testosterone”. The test that I previously had done this year (and two years ago) that says I have low-T is “Direct Free Testosterone”.

The physician wants me to stop all supplements for a month, have the test done again, and then see her.

I was hoping that there may be some expert here who can explain the exact difference between these two tests and why I am having a problem getting a clear answer that the doctor can use to prescribe treatment.

Pleas help if you can!

Ever have a thyroid panel done? Symptoms can be similar to low test and low WBC can be a sign that thyroid needs attention. Might be worth looking into.

iroczinoz, thanks for asking, but my thyroid has been checked numerous times (with free t3 and t4). I will post the numbers when I have the time. I’m fairly certain the testosterone is a big part of the problem here.

Okay, my doctor and I have figured out at least one thing to try.

We’re going to have the “Free T” and “Free Direct T” tests done on the same blood draw later this month.

I’m still looking for an explanation for why “Free T” was measured high after “Free Direct T” was measured low just a few months ago.