Help with Low E2

Please get stable and skip the excursions.

hCG 250iu SC EOD only please. 500iu simply doubles costs and can create other issues.

With 150mg T per week, we would expect that 1.5mg/week anastrozole would be good for normal anastrozole responders, the few others [not rare] need 1/4th that dose. So try 0.5mg anastrozole at time of injections.

There is no way to know in advance if you are an over-responder.

Stop anastrozole for 5 days then resume at new dose.

Do E2 labs in 3-4 weeks. Target is E2=22pg/ml and AI dose will be changed to get there. If you get E2=28pg/ml change old dose by a factor of 28/22 and you will be good.

I could do better if your anastrozole dose was not a secret.

Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.