This natesto seems like it could be a revolutionary step in TRT practice! I’m stunned by the fact that the feedback doesn’t get inhibited (as strongly) by pulsatile administration but since GnRH receptors work the same it’s not that outlandish a thought.
(i) pulsatile T is less effective than continuous T delivery in suppression of LH secretion, (ii) T feedback is reduced by BMI, and (iii) basal and total, but not pulsatile, LH secretion, estimated by deconvolution analysis is negatively correlated to visceral fat and total abdominal fat area, calculated from a single CT slice at L3-L4.
That’s what the study found. I like it, but we always gotta keep statistics in mind. Deconvolution is not the best way of getting data.
What’s also interesting was that free T and LH secretion correlated negatively with BMI (I think we knew that) which shows us again that fat people are hormonally fucked.
This might be a compensatory mechanism to decreased LH secretion in severe obesity
I’m surprised they got this approved by an ethics committee cause I wouldn’t be excited about getting 800 mg of Ketoconazole orally haha!
The discussion in the end about glucocorticoids and emotions is definitely a topic for another day.
A major discovery recently is that the pulsatility of cortisol is required for normal emotional and cognitive responses in man [42]
To the OP: I think you got some really good input here, I wish you and your family the best and report back how your fertility and T levels are going!
Also OP, maybe your Willy grows on HCG: