Greetings! I am having a very difficult time getting clear information on the functional use and efficacy of gonadorelin acetate for sex hormone production. The more I read about application the more I move closer to daily injections. 0.14ml of 0.2mg every day. I’m my own guinea pig. Is the half …

I’m already shut down and even though this is n=1, I have seen improvements and I can’t tolerate hCG. I’ve read a few studies that seem to indicate that there is no shutdown with kisspeptin-10 because it’s not a GnRG. It stimulates the pituitary to release GnRG. You don’t believe 100 mcg’s 3 times …

Too much kisspeptin-10 or 54 can cause excessive GnRH production which will eventually lead to GnRH receptor desensitization. I’ve spoken to the physicians directly that publish these papers and they all concur an infusion pump is the only real way as it stands now to deliver it in 2 hour boluses t…

Very interesting! Thanks for sharing. Short of infusion pumps or the device you’re looking to create, what’s your best guess for best utilization of kisspeptin-10 for those of us on TRT and are already shut down? Do you think kisspeptin is the best alternative aside from hCG and HMG currently?

My interest in Kiss-10 is first and foremost as a diagnostic for delayed puberty / normosmic congenital hypogonadotropic hypogonadism/Kallmann syndrome. There is no diagnosis currently for people that show signs during puberty of delayed puberty. Like me, a “late bloomer” turns into T lvls of 171…

Thanks for the detailed reply. When did you discover your condition and how old are you now? That sounds terrible and I can understand your focus and motivation. I also didn’t like Clomid. What problems have you had with injections? Can you elaborate on the below: how do gnhr receptors become dese…

Diagnosed at 26. Went on TRT for ~1.5 years had a mental breakdown and quit. Injections cause a lot of issues with libido/ED for me (and accentuated mania/psychosis). It’s very hard to figure out. Alcohol was not helpful. When I was 26 I was on 150mg/week a drinking almost daily and had a troug…

It’s so hard to tease out individual variables over time. I’ve gone through that as well. I’m sure that alcohol was changing your physiology. There was a time I was crushing my estrogen with an AI and drinking actually made me feel substantially better. I believe it had a multitude of affects, but i…

Sounds like a reasonable hypothesis, but the answer is I don’t know. You’d in effect be running a clinical trial on yourself. Hopefully with a TRT doctor. You’re right that the HPTA axis is already shutdown, and that means the Kisspeptin pathway is shutdown, as is the GnRH pathway. Who knows if t…

Thanks for your thoughts. Let us know if you get your device that allows for continuous microdelivery via needles/a patch in the market!

Hello Everyone, I’m new here to share news about my personal experience with Gonadorelin actate so far. 1st injection was Tuesday (nothing) 2nd injection was Saturday morning ( up and down erections and libido. Note: I stopped taking hcg about 3 weeks before I started taking Gonadorelin felt horr…

Gonadorelin Acetate Experiences, Outcomes & Dosage?

Pharma TRT

oppenheimer December 27, 2022, 7:29pm 41

Yes. Kisspeptin → GnRH → LH/FSH → Testosterone → Estrogen → negative hypothalamic feedback

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Gonadorelin Acetate Experiences, Outcomes & Dosage?

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