This typically doesn’t hold true. Testosterone is primarily metabolised hepatically via reduction and conjugation, estrogen is primarily metabolised via various cytochrome p450 enzymes and conjugation (one of which is an identical way to which test is metabolised). So unless you have significant hepatic dysfunction or an under active cyp1a1/cyp3a4 etc enzymes (of which would interfere with the clearance of estradiol metabolites) then E2 will increase/decrease proportionally to test. However this isn’t to say you don’t have this issue, I have a mutation in regard to one of my cytochrome p450 enzymes (cyp2d6, I contain multiple fully active copies of the gene), and thus I’m an ultra rapid metabolised of certain medications. Take codiene for instance, taking small amounts (say 10-20mg) dumps massive amounts of morphine into my system and is enough to make me totally out of it (so when it’s prescribed to me as cold medicine it’s a yeetfloopily time) whereas another would need 70-140 mg for the same effect. I’ve told this story before but when I broke my ankle, a family member gave me a hefty dose of codiene/acetaminophen… 2 pills of 30mg codiene/500mg acetomitophren… I was in the doctors office, doctor is telling me I need surgery and asap. I start not feeling so good (sphincter of oddi dysfunction), crushing pain in my ribs and I feel faint, as if I’m about to pass out.
Young unreal24278 “I don’t feel so good”
My father “uh huh”
Nurse “is he okay”
Me “really, I don’t feel good at all”
Father “stop complaining, you’re always complaining, one day it’s youre back, shoulder… you’re always in pain, just quit acting”
Aunt tries to calm me down as I’m lying down, tries to tell me I’m just having a panic attack because of the relevation of surgery… no one listens to me
Father “he’s acting, look we will get him to sit down”
Me… can’t move, now motionless/motor skills are gone
Father forces me into seat (he’s not a bad guy, just not always the most compassionate)
I lose consciousness for a few seconds, regain consciousness… throw up everywhere… get up and walk out of the doctors office
And regardless of the effect, using an ai to combat an estrogen dominance that lasts a couple days isn’t worth the potential risk (well unless it realllllly helps you)… and a suicidal AI would be far riskier to use for this purpose, as a mere 1-2 doses high enough could crash E for quite a while, so if it has to be done… stick to anastrazole/letrozole if possible
However these are very powerful meds not to be taken lightly, there’s a good reason as to why they’re primarily reserved for patients with breast cancer unresponsive to SERMS