Summary of information from director of “popular/leading” TRT/TOT clinic. This ellipse covers vast majority of the patients (>10,000 patients). Median dosing is 140 mg/week (range is 100 to 180 mg/week for most). You can see what that means in terms of mean TT levels (about half in range and the other half above range for mean TT). This graph collapses all the dosing strategies (E7D, E3.5D, EOD, ED) onto one plot using approach I shared previously:
| mean/trough ratio | peak/trough ratio | peak/mean ratio | check math | |
|---|---|---|---|---|
| q7d | 1.60 | 2.13 | 1.33 | 1.33 |
| q3.5d | 1.20 | 1.40 | 1.10 | 1.17 |
| qod | 1.09 | 1.14 | 1.05 | 1.05 |
| qed | 1.03 | 1.05 | 1.02 | 1.02 |
After a lot of argue with Danny (and to be fair and unbiased once I had the data) I wanted to share this plot as it shows many many guys are running supra at some point of all of the week and seeming to do well. Long term who knows. I respect the MD I got this info from so you can see the median is very close (140 mg/week) to Danny’s touted starting dosage of 150 mg/week. This provider is not running his patients to fT levels of 30-50 or 50+ ng/dl but there are a good fraction running up to 30 ng/dl.
Good luck everyone. It’s a brave new world.