Fatigue post dosing

I’ve been on TRT now for approximately 3 months and my testosterone levels have come up nicely. I’m also feeling much better mood wise, improved sex drive, and better overall energy. I initially started on twice weekly dosing (small dose of 30 mg cyp twice weekly + hcg 200 units, at the same time), but went to dosing every other day and at a lower dose because I was experiencing some anxiety and my provider thought it was likely due to estrogen spikes. I’m also taking anastrozole and was previously at 0.25 mg the day of dosing. Estrogen levels come back normal on blood work.

I have recently started noticing that I tend to be tired on the day of injection, approximately 2 to 3 hours after the dose (I’m dosing in the morning). I’ve increased my anastrozole to 0.5 my day of injection and 0.25 the day following. That seems to keep the anxiety symptoms under control but now have the general fatigue /no energy symptoms. The day after injection I feel great. Which makes me think it is somehow dose related.

Has anyone else experienced this? Any recommendations wrt time of dosing of T, when to take anastrozole relative to T, not injecting hcg the same day?

Appreciate any insight anyone might have.

I too had some post injection fatigue. However, as a side effect it was short lived. Maybe a month or so. My advice to you is to try not to over correct your symptoms with different protocols and dosing schedules. Make one change and let things settle out for 6 wks. before making another change.
Am I correct in that you are dosing at 60mg total test cyp. for the week?

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Thanks for the quick reply. I’ve been doing 20 mg every other day now for a while. Which averages out to 70mg per week I believe. Yeah I do tend to want to make changes when I’m not feeling great, so good advice to not make too many changes at once. I did decide to try dosing my hcg on the off day (this morning I dosed T but no hcg and was planning to do that tomorrow, just because of the intensity of fatigue with both done the same time). I don’t love the idea of injecting something every day though.

At your dosage and dosing schedule I believe that you would fall well outside the curve for those requiring an AI. Do you have blood tests to support the need for an AI? and were you having high E2 symptoms?
Also, Is there any particular reason for taking HCG? Fertility, Shrinkage? etc.

I was on hcg monotherapy for a little over a year and had a lot of anxiety which was why I was on the anastrozole. And estradiol levels were always in the 50-60 pmol/L range. I stopped it when I started on T, and after my first 2 month bloods, e2 was in the 90s and instructed to restart again. No gynecomastia or fluid retention that I’m aware of.

And hcg to prevent shrinkage now with T

HCG mono therapy will increase your E2 levels
HCG + Testosterone will increase your E2 levels even more.
I’ve been one TRT for a year at 140-160mg per week and have noticed zero shrinkage without HCG.
To me it sounds like you are taking additional drugs to counteract the effect of other drugs.
If your taking HCG in order to lessen the effect of POSSIBLE shrinkage. I would remove the HCG. Keep your test the same and do nothing for 6 wks then retest for TT, FT, SHBG and E2 and see where you land.
All though your E2 does seem high for the amount of test you are taking. It’s probably elevated because of the HCG.
The way it stands now. You need to take anastrozole to counter act the effects of the unneeded HCG.
Just my .02 cents

Thank you! Appreciate your input. Yeah I should probably consider the need for hcg.

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I take my T (and anything else that causes fatigue or brain fog) in the evening so I can sleep through the effects.

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Thanks for this!