All I can find are studies on women with breast cancer who take 1mg/day of Anastrozole and keep their E2 close to 0 pg/mL for years on end and ultimately end up having serious health issues.
Are there any studies showing that AI’s are inherently bad for you even in small dosages to keep your E2 within normal range?
Dis gon b good 
Some men can’t keep E2 in range no matter the AI dosage (0.050), therefore AI’s are bad for them.
E2 has all sorts of health benefits so you don’t want to use an AI unless necessary and in that instance you want to keep your E2 as high as possible without sides. When I took and AI my HDL noticeably dropped by about 20% and my LDL increased almost the same as a reference to just one of the negatives of AIs.
I’m thinking about it because I tried every possible protocol and always feel sluggish physically and mentally. No drive, can’t push myself when working out even compared to when I was natural with low T. A little bloated also, even on a low dose.
My last protocol I’ve been doing 125 mg/week in daily injections. Free T is just at the top of the range (25ng/dL), all health markers look great, but I still feel sluggish and apathetic. Only thing I can think of is E2 (sensitive) is way out of range.
How much did you take when you took an AI? I was thinking of trying a small dose, maybe 0.125mg twice/week, and see what happens
What did your labs show? I was on .25mg with each pin at 2x per week. Your starting dose seems reasonable.
My E2 (sensitive) was around 60 pg/mL with a range of <29 pg/mL.
So while my TT and FT are at the top of the range, my E2 is 2x the range. I think that’s the problem. It would make sense to me if they were all around the same percentile/number of standard deviations, but that’s clearly not the case. E2 is relatively speaking way higher than TT or FT for me.
I want to at least try to get E2 around 30pg/mL and see if it makes a difference. I honestly don’t know what else to do at this point.
Losing 30 lbs. of fat can decrease estrogen substantially.
Not really. It is not approved for use in men and considered off label. Given the differences in the way humans respond to hormones, it is probably a mistake to focus on lab numbers when using TRT.
Anastrozole Administration in Elderly Hypogonadal Men - Full Text View - ClinicalTrials.gov
Ask yourself what exactly is “normal range”, and does this range include men on exogenous testosterone. Or is the “normal range” specifically for men who are not on exogenous testosterone?
My E2 was “perfectly” in range for 7 years while on anastrozole with TRT. Every blood test result showed E2 in the low to mid 20’s, right where my TRT provider said was perfect.
I developed excruciating joint pain in my feet and ankles, that went away after I stopped anastrozole.
Can I ask what your protocol was for Test and Anastrozole during that time?
160-200 mg per week testosterone, split into two doses. IOW, e3.5 days.
.25mg anastrozole approx. 24 hours post injection.
None that I’ve found yet, and I’ve def looked around. Seems to be all the AI or none of the AI in the medical community so far
Prolactin levels? I think som sides of high e2 can be attributed to PRL