Estradiol: Why You Should Care

[quote]KSman wrote:
I found a good book on this: …[/quote]

Just checking to see if you had written your book yet.

[quote]thr61 wrote:
I have been off this board for a while seeing if my TRT treatment protocol is working.

Current situation is as follows: 48 years old, blood work last week:

E2 = 51

TT = 597

SHBG = 31.3

I am current on 120 subcu T cyp divided in 2 doses, 25 units HCG 2 x weekly, 20 mg Danzol 5x weekly.

I finally got my doctor to prescribe arimidex and now have a bottle of 1 mg tablets. He started out prescribing .2 mg 2x weekly. I am guessing this is way too little. Since the pills are hard to divide, I should have enough to take a bit more. My thought is to go with .25 mg 2x weekly, or do you think more makes sense given my levels?

Thanks for all thoughts. The E2 problem has been my biggest challenge with all of this so far.[/quote]

For most men, 1mg/week of adex will lower their E2 level by 1/2. Cut the tabs into 1/4’s (I do)
and as an example take 1/4 on Sunday, Tuesday, Thursday, and Saturday or whatever suits your schedule best. I don’t know what you weigh, but if it is a long way from 160 pounds, 1mg/week may not be enough, unless you are an over-responder.
A friend of mine weighs around 260 and most of it is fat, so he decided to take 1/4mg six days a week, and wait two weeks. His libido started to return, but it wasn’t “enough” he thought, so he started taking 1/2mg M,W,F, and 1/4mg T,TH,Sat. The mornings following the 1/2mg tab days his life sucked, and the 1/4 tab days were just fine. If you go from mediocre erections to erections that are unbelievable, great, but if the the great ones won’t orgasm no matter what you do, it’s too much adex.

I am 6’ 1" and weigh 190. My BF is about 9-10%. I am going to go with .25 tab 3x weekly and see how that goes. I will get tested in 2 weeks and then adjust from there. Make sense or should I push it to the full 1 mg per week?

[quote]thr61 wrote:
I have been off this board for a while seeing if my TRT treatment protocol is working.

Current situation is as follows: 48 years old, blood work last week:

E2 = 51

TT = 597

SHBG = 31.3

I am current on 120 subcu T cyp divided in 2 doses, 25 units HCG 2 x weekly, 20 mg Danzol 5x weekly.

I finally got my doctor to prescribe arimidex and now have a bottle of 1 mg tablets. He started out prescribing .2 mg 2x weekly. I am guessing this is way too little. Since the pills are hard to divide, I should have enough to take a bit more. My thought is to go with .25 mg 2x weekly, or do you think more makes sense given my levels?

Thanks for all thoughts. The E2 problem has been my biggest challenge with all of this so far.[/quote]

There is plenty on info on the site that will show you where you want to go with that E2 level. My estradiol is a slight bit higher than yours (I’m only 20!) and I have something to help me with that. I’ll get back to you on my blood tests once they’re done and I’ve been on for a few weeks.

42 y.o. 220lbs 6’1
Low t symptoms since last January(most likely since my mid twenties now that I recognize the symptoms) My primary doc was reluctant to even consider TRT. I researched and ended up at the office of one of the pioneers in TRT. Began Androgel in December. Finished at 8 pumps and No improvement(TT 328) and put on 18lbs mostly gut and moobs. Had weird side effects at around 4 months:around 5 hrs after application sick, weak gonna die flu like waves, and anxiety. Would pass after a few hours. This forum finally enlightened me to the E2 connection. Doc decided I’m not a good TD absorber(last month).Made appt to start Test Cyp 100 weekly. I printed some info from here about E2,hCG and AI. I mentioned the side effects as well. My highest E2 was 39 best was 24 and recent was low. He couldn’t discount some kind of gel side effect but totally dismissed the suggested protocol (T + hCG + AI). He said they only use those separately as TRT modes… not all at once. He even said high E2 is not a bad thing! He conceded if and only if I get gyno symptoms he might consider Arimedex. Just took first T inj 100mg 4 days ago. I will go every 3.5 days with 50mg from here but am I better off to just RC’ing the Hcg and AI? I have concerns with how to know trustworthy RC sources.If my symptoms were from E2 I want to preempt that scenario by all means… it felt horrible.

bylli, You need a new doc. Are you seeing shippen? Find and talk to compounding pharmacies, explain your case and get referrals. Use Google earth to find “compounding pharmacy” in the ‘fly to’ box and explore the websites.

[quote]KSman wrote:
bylli, You need a new doc. Are you seeing shippen? Find and talk to compounding pharmacies, explain your case and get referrals. Use Google earth to find “compounding pharmacy” in the ‘fly to’ box and explore the websites.[/quote]

hello KS,man…where should I post a ? about T ? and whats goin gon now with my indiot of a dr. ? do want to hi-jack anyones thread…

[quote]fightu35 wrote:
KSman wrote:
bylli, You need a new doc. Are you seeing shippen? Find and talk to compounding pharmacies, explain your case and get referrals. Use Google earth to find “compounding pharmacy” in the ‘fly to’ box and explore the websites.

hello KS,man…where should I post a ? about T ? and whats goin gon now with my indiot of a dr. ? do want to hi-jack anyones thread…[/quote]

Open a new thread with current dosing, timing and lab numbers.

[quote]KSman wrote:
bylli, You need a new doc. Are you seeing shippen? Find and talk to compounding pharmacies, explain your case and get referrals. Use Google earth to find “compounding pharmacy” in the ‘fly to’ box and explore the websites.[/quote]

We are located just 45 minute from shippen. We have alot of his patients actually because hes getting to retire. Feel free to PM me.

ok thank you…I after months founda dr.,just got blood work today…full metabolic profile…crp protein,glucose,test…E2…etc…
he was talking about using TEST PELLETS…thanks again

[quote]KSman wrote:
fightu35 wrote:
KSman wrote:
bylli, You need a new doc. Are you seeing shippen? Find and talk to compounding pharmacies, explain your case and get referrals. Use Google earth to find “compounding pharmacy” in the ‘fly to’ box and explore the websites.

hello KS,man…where should I post a ? about T ? and whats goin gon now with my indiot of a dr. ? do want to hi-jack anyones thread…

Open a new thread with current dosing, timing and lab numbers.[/quote]

Is there a thread for finding hCG on line with out a perscirption.

[quote]GeoBob wrote:
Is there a thread for finding hCG on line with out a perscirption. [/quote]

Please note the subject of this sticky! -and no

[quote]KSman wrote:
GeoBob wrote:
Is there a thread for finding hCG on line with out a perscirption.

Please note the subject of this sticky! -and no[/quote]

you have a PM sir,thank you

I’ve been following this thread on and off for a while now, very helpful, especially KS and happy, many others as well.

I have not seen anything relative to sugar and T levels. I ran across this bit of information and wanted to post it, I do apologize if it has already been mentioned:

http://cancerres.aacrjournals.org/cgi/content/full/66/11/5960

One question, is it the general consensus that if your DHEA levels are below the range (70-310 ug/dL) that they should be supplemented? I was told that DHEA can be converted to cortisol (or estradiol) if too much is taken, is this true?

Thanks in advance for all replies.

When TRT is low and there is insulin resistance, often as part of the spectrum of syndrome X or metabolic disorders, TRT can improve insulin sensitivity. Insulin resistance in extreme is type II diabetes. Chromium as a trace element is important for sugar metabolism, and some other TEs.

The testes make most of your pregnenolone, the adrenals make most of your DHEA from pregnenolone. In the testes, DHEA progresses to progesterone then cortisol as NEEDED. The testes use DHEA to make testosterone as NEEDED. DHEA does not spontaneously turn into other hormones.

If DHEA is low, that can rate limit the production of down stream hormones, then DHEA supplementation can address some of that. Men and women start to loose significant levels of DHEA after 30 years of age. And we all start to age significantly from there. There are some good argument to supplement DHEA and there is a lot written about that. Because drug companies are not getting profits, they are not in control of what you here. But the message is still not simple or clear.

Guys on TRT without hCG have their testes shutdown and loose the biggest single source of pregnenolone in their bodies. That lowers DHEA and all of the other steroid hormones. Brain, mind and body all suffer.

You can safely take DHEA supplements. If your E goes high, that is another problem that needs to be studied and dealt with. If your cortisol is high, you need to look at how you are stressing your mind and body before the adrenals get weakened… another kind of hell. You do not want to manage E2 or cortisol with a lack of DHEA.

I’ve read through a lot of threads and searched online and come up with very little in terms of where to find Arimidex/Liquidex. I’ve been doing TRT for nearly a year now, and while both the total and free T are much better, my E2 is 38 (the high on this range is 41). I know I should be closer to like 20, so I asked my doc if being nearly double that was a problem. Of course she said no. I’m pretty confident that isn’t correct.

I guess my question first is would Anastrozole be the way to go here (I’ve read 1mg per week would be an adequate dose), and second (and it seems people can’t answer this in the thread), but how would I go about finding a reputable site to order it? I’d greatly appreciate some help either here or via PM. Thanks in advance.

I have been adding 1mg liquidex (0.5 twice per weeks) and 250iu twice per week hcg to my nebido protocol but have killed my Estrogen level (test = 29pmol/l (43.0 - 151.0))Testosterone is up nicely at 19nmol/l and I feel great no stiffness etc but morning wood is getting weaker.

Would a large shot of HCG get the Estrogen number back up in range. I have a specific reason to get the estrogen number for early next week rather than just stopping the liquidex and waiting a couple of weeks.

I hope this is felt to be relative to this thread if not please feel free to move it mods

Regards from UK

kesam: Less or no adex will have a predictable result. hCG response is not predictable. Depends on age, how long the testes have been shutdown, how much they have shrunk, how fast they recover and how well then work when recovered. If you have recovered with hCG, then any E2 response will be faster.

If you take 1/2 of the adex, E2 might double. You might be an anastrozole over-responder. That would typically require 1/4th of the expected dose.

If you dose adex EOD, then E2 levels will be steadier. You could have sampled a low point. How you dose T also plays into this. T levels will swing over a period of months with nebido. Your E2 levels depend on ratio of adex to TT [probably bio-T]. So we can expect E2 levels to swing over a period of months. Your adex dose and E2 cannot be well controlled.

[quote]happydog48 wrote:
mikemass wrote:
Finally, has anyone considered using 6-OXO vs. arimidex for aromatase inhibition? Seems there’s some support for its effects:

I’ve used 6-OXO and found it to be not very effective at 300mg per day. It worked better at 600mg per day but I can’t justify the cost. Anastrozole works well and nothing else comes close to the price.

[/quote]

The pub med report stated that DHT was increased with 6-OXO. Isn’t DHT the culprit that causes hair loss?

250 eod of HCg and dropped the liquidex for now. Yesterday must have been similar to going cold turkey on some sort of drug. I’m positive my E2 must have hit zero, my wife said I looked drunk and I was sweating like a menopausal woman, tried to get in the gym but no way was my body having it. Feeling a lot better today and on the way up again I’m sure.

I know I wasn’t ill as I am a diabetic and my blood sugars were fine so it had to be something hormonal. I appreciate the advice KS but I wont be touching the liquidex again until I get itchy nips. I don’t wish that on my enemies.