Estradiol: Why You Should Care

Pharma TRT
302

[quote]itisme wrote:
when is the best time to take anastrozole? In the morning or before sleep? thanks for replies.[/quote]

I tell everybody to take it at night, that way it’s easier to judge your morning wood response. If you take it in the morning, you might be pitching a tent at work, (or not) and that’s not a good idea for for most of us…

Most of the guys I know that didn’t have consistent morning wood from taking their adex in the morning, switched to evening dosing and now have a predictable “response”.

303

[quote]Chushin wrote:
Assuming you haven’t yet, I’d get tested for an estradiol level. (Hopefully your doc isn’t one of those who believes it’s irrelevant!)[/quote]

Yes, I asked and basically they wrote me off. “Your levels look fine”. What about my estradiol levels. But your testosterone levels looks fine…but…argh…So now I’m considering using an AI until I can find a doctor willing to help.

304

so it seems… ‘wood’ seems to be a good measure of things…so 1-2 times during night while a sleep is good ? and then when i wake up ??

305

[quote]Get out the Door wrote:
buffd_samurai wrote:
Just a simple question (don’t know why I can’t seem to figure it out myself): is there a benefit (other than cost) of using arimidex versus aromasim? Arimidex appears to have some issues with increasing aromatase production after a time which forces the continual use of the product (not that this is a bad thing).

There also appears to be issues with lipid levels associated with arimidex (i.e. LDL increases, HDL decreases) and joint pain issues when too much is used.

From what I’ve read, aromasin (exemestane) appears to not suffer from any of those listed above. Lipid levels don’t go bad; aromatase production is not upregulated by the body (therefore no suffering from estrogen dominance upon cessation of use), and there appears to be some evidence with respect to a positive effect on bone mineral deposit.

Am I missing something?

I had a nice long response to this deleted. Dam computer

In a roundabout way, everything you said is correct.

Note that aromasin also boosts, or at the least, maintains IGF-1 levels. Arimidex, in many cases, reduces such levels.

[/quote]

The company I work with (Renewman) did my blood work and told me I have no pituitary output whatever. Time for HGH?

306

Headhunter,you can test for that ? what test do I ask for ,to have the out put tested ?

307

[quote]fightu35 wrote:
Headhunter,you can test for that ? what test do I ask for ,to have the out put tested ?[/quote]

Best one is the Arginine Infusion test (4 hours long, lots of vomiting), the other way is to test for IGF-1.

308

[quote]Headhunter wrote:
Get out the Door wrote:
buffd_samurai wrote:
Just a simple question (don’t know why I can’t seem to figure it out myself): is there a benefit (other than cost) of using arimidex versus aromasim? Arimidex appears to have some issues with increasing aromatase production after a time which forces the continual use of the product (not that this is a bad thing).

There also appears to be issues with lipid levels associated with arimidex (i.e. LDL increases, HDL decreases) and joint pain issues when too much is used.

From what I’ve read, aromasin (exemestane) appears to not suffer from any of those listed above. Lipid levels don’t go bad; aromatase production is not upregulated by the body (therefore no suffering from estrogen dominance upon cessation of use), and there appears to be some evidence with respect to a positive effect on bone mineral deposit.

Am I missing something?

I had a nice long response to this deleted. Dam computer

In a roundabout way, everything you said is correct.

Note that aromasin also boosts, or at the least, maintains IGF-1 levels. Arimidex, in many cases, reduces such levels.

The company I work with (Renewman) did my blood work and told me I have no pituitary output whatever. Time for HGH?

[/quote]

“”"
There also appears to be issues with lipid levels associated with arimidex (i.e. LDL increases, HDL decreases) and joint pain issues when too much is used.
“”"

Totally wrong!!!

The problem and that people do not understand the context of what they read. WE are using Arimidex/anastrozole to lower E2 levels to that of a young lean virile male. Those guys have excellent lipid profiles.

Women who use Arimidex or other AIs to force E2 down to levels close to zero can have lipid and other problems created by a lack of estrogen. Some body builders who are trying to eliminate all fat to increase muscle defintion also can have problems.

Males who are lowering E2 to the lower 20’s [<54 pg/ml]do not have lipid problems. A large number of TRT guys in this forum have lab results to back this up.

“”"
… and joint pain issues when too much is used.
“”"

When used too much: There are a lot of things that have adverse results. We should stick the implications of using things properly.

309

[quote]Headhunter wrote:
fightu35 wrote:
Headhunter,you can test for that ? what test do I ask for ,to have the out put tested ?

Best one is the Arginine Infusion test (4 hours long, lots of vomiting), the other way is to test for IGF-1.

[/quote]

vomiting ? Ill take the IGF-1 im going next week…so Ill ad that, thanks again

310

I recently had my testosterone levels checked. My total testosterone is 313. I do not have all of my results yet. My doctor tested for TT, FT, E2, Prolactin, T3, T4 and Hematocrit. They said my other results were normal but I do not have a copy of them yet.

My doctor wants to put me on androgel. My question is should I get them to test my LH levels first, or does the Prolactin test suffice? Does a normal Prolactin test indicate that LH levels are also normal? I was wondering if I should explore hCG therapy first or if the normal Prolactin test eliminates that from the table.

For the record I am 31 years old and have been having symptoms for 7 years or so. I originally thought I was just depressed or had seasonal depression and I never considered that I might have low testosterone because of my age and the fact that I am a big SOB.

311

Normal prolactin levels indicate your pituitary is functioning correctly, which would suggest that LH levels will also be within range.

Your doctor is going to believe that your hypogonadism is primary (your testes aren’t functioning correctly) in which case, he will say hCG probably won’t help. Plus, people are abusing hCG right now for weight loss and so scrips for hCG are getting a closer look and he’ll probably do everything he can to avoid writing one.

As for being a big SOB, that needs some clarification. If you’re big and lean, that’s one thing, but if you’re big and fat, then that’s an issue because fat produces E2 AND aromatase and if your aromatase and E2 are elevated, then that in itself could explain lower T levels and your symptoms. Just because your E2 is in range, doesn’t mean it is where it should be, so if I were you I would want to see the numbers.

312

[quote]happydog48 wrote:
Normal prolactin levels indicate your pituitary is functioning correctly, which would suggest that LH levels will also be within range.

Your doctor is going to believe that your hypogonadism is primary (your testes aren’t functioning correctly) in which case, he will say hCG probably won’t help. Plus, people are abusing hCG right now for weight loss and so scrips for hCG are getting a closer look and he’ll probably do everything he can to avoid writing one.

As for being a big SOB, that needs some clarification. If you’re big and lean, that’s one thing, but if you’re big and fat, then that’s an issue because fat produces E2 AND aromatase and if your aromatase and E2 are elevated, then that in itself could explain lower T levels and your symptoms. Just because your E2 is in range, doesn’t mean it is where it should be, so if I were you I would want to see the numbers.[/quote]

I believe his business actually prescribes hCG for weight loss in women.

I am 6’5" and 290. I am a former college football player and was a strength & conditioning all-american in college. I don’t think I’m fat, but there is always room for improvement I suppose.

I will post my test results when I get them in the mail.

Thank you for your advice. I think this is the only forum on T-Nation that you can post a question and expect an honest educated answer.

314

[quote]Chushin wrote:
BigBen72 wrote:
Thank you for your advice. I think this is the only forum on T-Nation that you can post a question and expect an honest educated answer.

That’s because we keep young, under-35 kids like you out!

Ha ha, just kidding. This IS the best forum here.

Good luck to you.[/quote]

Thanks for the kind words.

My test results are as follows:
E2 21 pg/mL Ref. Range: 12-41 pg/mL
Prolactin 5.8 ng/mL Ref. Range: 2.1-17.7 ng/mL
Testosterone 313 ng/dL Ref. Range: 175-781 ng/dL
Free Testosterone 9.3 pg/mL Ref. Range: 8.7-25.1 pg/mL
Hemoglobin A1C 5.3 Ref. Range: 4.0-6.0
TSH 1.65 ulU/ml Ref. Range: .34-5.6 ulU/ml
T4, Free 1.2 ng/dL Ref. Range: .6-1.2 ng/dL

315

[quote]BigBen72 wrote:

My test results are as follows:
E2 21 pg/mL Ref. Range: 12-41 pg/mL
Prolactin 5.8 ng/mL Ref. Range: 2.1-17.7 ng/mL
Testosterone 313 ng/dL Ref. Range: 175-781 ng/dL
Free Testosterone 9.3 pg/mL Ref. Range: 8.7-25.1 pg/mL
Hemoglobin A1C 5.3 Ref. Range: 4.0-6.0
TSH 1.65 ulU/ml Ref. Range: .34-5.6 ulU/ml
T4, Free 1.2 ng/dL Ref. Range: .6-1.2 ng/dL
[/quote]

Tyroid seems good with that T4 level. But watch that T4 does not go over range over time. Your lower TSH level suggestes that your thyroid has no problem making hormones.

Your E2 appears to be very good. However, your TT is low and your FT is low as well. So your E2 would not appear to be lowering T via HPTA repression. But your E2:FT ratio is probably adverse in some respects.

TRT will be good for you. If you train, sweat and shower a lot, transderal T may be wrong for you and your alternative would be injections.

When you start TRT, you should start Arimidex at the same time. And you need 250iu hCG SC EOD to keep your testes alive.

Dose on-TRT Arimidex to keep E2 at 22pg/ml. Scale your starting dose to be your weight divided by 160 to get milligrams per week.

T+AI+hCG

316

[quote]KSman wrote:
BigBen72 wrote:

My test results are as follows:
E2 21 pg/mL Ref. Range: 12-41 pg/mL
Prolactin 5.8 ng/mL Ref. Range: 2.1-17.7 ng/mL
Testosterone 313 ng/dL Ref. Range: 175-781 ng/dL
Free Testosterone 9.3 pg/mL Ref. Range: 8.7-25.1 pg/mL
Hemoglobin A1C 5.3 Ref. Range: 4.0-6.0
TSH 1.65 ulU/ml Ref. Range: .34-5.6 ulU/ml
T4, Free 1.2 ng/dL Ref. Range: .6-1.2 ng/dL

Tyroid seems good with that T4 level. But watch that T4 does not go over range over time. Your lower TSH level suggestes that your thyroid has no problem making hormones.

Your E2 appears to be very good. However, your TT is low and your FT is low as well. So your E2 would not appear to be lowering T via HPTA repression. But your E2:FT ratio is probably adverse in some respects.

TRT will be good for you. If you train, sweat and shower a lot, transderal T may be wrong for you and your alternative would be injections.

When you start TRT, you should start Arimidex at the same time. And you need 250iu hCG SC EOD to keep your testes alive.

Dose on-TRT Arimidex to keep E2 at 22pg/ml. Scale your starting dose to be your weight divided by 160 to get milligrams per week.

T+AI+hCG[/quote]

is e2 of 12 alittle low I am experiencing symptoms of over dosing on adex according to the instrucitons

317

“is e2 of 12 alittle low I am experiencing symptoms of over dosing on adex according to the instrucitons”

Is that a typo? E2=12 pg/ml will create serious problems!

318

[quote]KSman wrote:
BigBen72 wrote:

My test results are as follows:
E2 21 pg/mL Ref. Range: 12-41 pg/mL
Prolactin 5.8 ng/mL Ref. Range: 2.1-17.7 ng/mL
Testosterone 313 ng/dL Ref. Range: 175-781 ng/dL
Free Testosterone 9.3 pg/mL Ref. Range: 8.7-25.1 pg/mL
Hemoglobin A1C 5.3 Ref. Range: 4.0-6.0
TSH 1.65 ulU/ml Ref. Range: .34-5.6 ulU/ml
T4, Free 1.2 ng/dL Ref. Range: .6-1.2 ng/dL

Tyroid seems good with that T4 level. But watch that T4 does not go over range over time. Your lower TSH level suggestes that your thyroid has no problem making hormones.

Your E2 appears to be very good. However, your TT is low and your FT is low as well. So your E2 would not appear to be lowering T via HPTA repression. But your E2:FT ratio is probably adverse in some respects.

TRT will be good for you. If you train, sweat and shower a lot, transderal T may be wrong for you and your alternative would be injections.

When you start TRT, you should start Arimidex at the same time. And you need 250iu hCG SC EOD to keep your testes alive.

Dose on-TRT Arimidex to keep E2 at 22pg/ml. Scale your starting dose to be your weight divided by 160 to get milligrams per week.

T+AI+hCG[/quote]

Interesting…so, to make sure I’ve got it, my weight (254 lbs) divided by 160 would be my weekly Arimidex dose, spread out over 7 days? Roughly 1.75 mg (the caps come in .25 mg), so one cap per day? Or is 2 EOD better? I know you like the EOD protocol.

And BigBen…I am jealous of those numbers, bro, 'cept for the T! Lucky!!

319

That is a good on-TRT starting dose until labs or other suggest adjustments. With a later lab, with E2=Y as the result and E2=22 the goal, new dose would be old_dose x Y/22

All need to understand the implications of been an adex over-responder.

320

[quote]KSman wrote:
That is a good on-TRT starting dose until labs or other suggest adjustments. With a later lab, with E2=Y as the result and E2=22 the goal, new dose would be old_dose x Y/22

All need to understand the implications of been an adex over-responder.[/quote]

I started the Arimidex at .25 mg EOD. Felt great for 2 or 3 weeks, then everything kind of disappeared and my libido crashed. I feel like the dentist who was trying to drill my 6 year old daughter’s tooth and the target keeps moving!
AAARRRRGGGHHHH! ;>