Dose response of LH / Endogenous T suppression with exogenous TC administration in healthy male subjects (with 95% individual confidence limits):
I’d have to dig for the SARM data which IIRC there’s some variation in the dose response on LH suppression for various SARMs.
Good question.
https://academic.oup.com/jcem/article/103/9/3215/5047294
No detectable LH suppression which tells me the TT drop was explainable by drop in SHBG (i.e., free T if measured would not have dropped and that no real HPTA suppression). The authors of the study don’t seem to get that :-). See the next sentence after the highlighted part. Next time they should measure fT using LC-MS/MS + equilibrium dialysis and I’d bet fT didn’t change over the time course.
In this study the authors used Vermeulen calculation for fT estimate. As shown, almost no suppression of fT level and again to be accurate they should have measured with equilibrium dialysis. TT followed the SHBG drop.
No measurable suppression of LH levels:
TT follows SHBG which will drop with SARM use. I’d agree after going back and scanning literature (see posts above) that your endogenous production (LH and fT) weren’t meaningfully suppressed if at all. Hence SARM data shared indicates minimal to no HPTA/LH/endogenous T shutdown for a 30 day course.
This, in combination with the lowering of lipids with RAD140 makes a pretty strong case that the cycle I took could be safer than any regular Test blast IMO.
Hmmm, interesting hypothesis. I’d look at the lipid data from the studies I posted as well as the liver data. Higher dosing looks to mess up your lipid particle counts (LDL up, HDL down).
YMMV. Good luck. I’m wary enough of Pharma grade stuff from compounding pharmacy. I would never roll the dice with research chemicals or internet supplements.
Honestly I’m going to need a bit to sit down and comprehend everything in this graphic 
Knowing what I know now, I wouldn’t either. But this was all when I was young and dumb (still young, a little less dumb).
Can I ask why? I’ve heard/seen some heat directed towards compounding pharmacies (I think some was generated by you RE faked pharma HGH (?)) and was curious if you knew more.
Are you one of the folks that does your own compounding as to avoid this?
Imma go a bit off the topic, but looking at @tareload latest posts i became interested… so you have lots of references to data about what works, what not, whats good, whats bad…
BUT… do you have the info, or would be willing to switch your focus for an experiment?
Could you gather info and write up a “perfect steroid blast” ? I would be willing to do it, if you would be willing to switch your focus for this experiment 
You might need to give him some parameters to work within. “Perfect” is subjective anyway but goals for the blast would be appropriate starting point.
Imo there is only 1 objective - build as much lean muscle as possible.
I dont think people should blast to cut as cuts take longer than average blast and the whole blast idea in no way speeds up the cut.
Yes, but that’s where the parameters are important. If the only parameter is to put on as much lean mass as possible, then just permablast 2g test/wk, 500mg tren/day, 20iu HGH/day and add insulin. But obviously this is a stupid cycle because imminent death awaits.
So parameters… (examples)
But if the question was being asked for a first time AAS cycle…
These are examples of parameters and why they would vary from person to person. A blast for you would look massively different than a blast for me
Done it, didnt work. (not the 500mg tren a DAY? That wouldnt produce gains, it would produce death). did around 800mgs a week tho.
yes
for the sake of fun - lets turn this one off… nothing good ever comes to those who think about health besides…health, haha 
yes
No…
Thats why i asked him if he is up to it. Because he might have some actual info on - is 20iu of GH actually doing anything.
Going by stuff he posted on this thread - i didnt even know there was such research so im sure i dont know what else is there.
I was wondering if he could switch his health saving mindset to producing GAINS, and just use the knowledge of literature to actually produce gains with scientifically supported advice.
For example, 20ius of GH might not be better than 10…
Also 2gs of test might only do 10% better than 800mgs of test. I dont know if he has such info and abilities but thats why i asked.
But yes, the experiment is for me. I would be willing to try it.
I’m not poo-poohing the idea of a ‘smart’ blast for those who are advanced in the realm of AAS, I was just trying to make a point that parameters (as @blshaw mentioned) are absolutely needed when it comes to giving AAS advice.
It’s not that you are a newbie, but if a newbie poster comes on asking for cycle advice - the first thing everyone does is vet him/her to see what advice is best given in the scenario. If the poster is definitely NOT a newbie to AAS, then different advice is given. This vetting process, in a way, is the same thing as providing parameters. Same thing here, that’s all
I love you too but you may be giving me too much credit. I spend my time on here for free (delusionally) in the hope of making an impact for harm reduction. If I was to go full darkside then I would try to get paid $$ like all these other coaches. But that’s not me.
If you turn remove the health/safety constraint to the below graph then it becomes dosing/drug choice question:
So we arrive at the issue of you and I being “sinks” as you like to paraphrase @RT_Nomad . Then you have to get more creative on your methods:
I’ll give this some thought.
I think it comes back to what a well-known NPC competitor told me circa 1997. “Dude, you need to find another hobby.” Some guys just have the genes for it and some don’t until we figure out how to use CRISPR safely in humans. But then it won’t be fun since anyone will be able to do it and only scarcity creates value…
Case Report
Figure 1.
Photographs of the Child at the Ages of Six Days and Seven Months (Panel A), Ultrasonograms (Panel B) and Morphometric Analysis (Panel C) of the Muscles of the Patient and a Control Infant, and the Patient’s Pedigree (Panel D).A healthy woman who was a former professional athlete gave birth to a son after a normal pregnancy. The identity of the child’s father was not revealed. The child’s birth weight was in the 75th percentile. Stimulus-induced myoclonus developed several hours after birth, and the infant was admitted to the neonatal ward for assessment. He appeared extraordinarily muscular, with protruding muscles in his thighs (Figure 1A) and upper arms. With the exception of increased tendon reflexes, the physical examination was normal. Hypoglycemia and increased levels of testosterone and insulin-like growth factor I were excluded. Muscular hypertrophy was verified by ultrasonography when the infant was six days of age (Figure 1B and Figure 1C). Doppler echocardiography and electrocardiography performed soon after birth and every six months thereafter were consistently normal. At 4.3 years of age (body-surface area, 0.78 m2), the child had a pulse rate of 95 beats per minute, a left ventricular ejection fraction of 70 percent, fractional shortening at the midwall of 56 percent, and a cardiac output of 2.81 liters per minute, with a left ventricular measurement of 3.42 cm during diastole (50th percentile) and 1.99 cm (25th percentile) during systole and respective septal measurements of 0.59 cm (75th percentile) and 0.81 cm (75th percentile).
The stimulus-induced myoclonus gradually subsided after two months. The child’s motor and mental development has been normal. Now, at 4.5 years of age, he continues to have increased muscle bulk and strength, and he is able to hold two 3-kg dumbbells in horizontal suspension with his arms extended.
Several family members (Figure 1D) have been reported to be unusually strong. Family member II-3 was a construction worker who was able to unload curbstones by hand. The 24-year-old mother of the child (III-5) appeared muscular, though not to the extent observed in her son; she did not report any health problems. No family members aside from the mother were available to provide samples for genetic analysis.
Read this last paragraph carefully:
It’s been the talk for decades now that myostatin inhibitors would be the thing. I’m waiting for them
Me as well, hence giving up blasting to just do TRT cruising.
I tried a cycle of YK-11 and had okay results but nothing crazy noticeable. Not worth the sides I had; wouldn’t recommend. That being said, the science looked good 
https://www.sciencedirect.com/science/article/pii/S0006291X21000668
(sorry, it’s the most scientific article I could find about YK-11)
@tareload thanks for the info and insight. I’m glad you reference with some actual science. I know many go to bro science, which does have merit, but research always helps.
I’ll admit I bought it on a whim because it was in limited supply. Wasn’t sure if I’d ever use it or sell it. I’m in the same boat with mk677. Bought a ton but due to potential blood sugar issues I’m not sure if its worth it.
In terms of sarms I’ve used ostarine at 25mg with great sucess… well… consindering its a Sarm and not AAS.
Long story short I used it for 3 month along with BPC 157. My shoulder went from needing surgery to full recovery.
Then the following year I did a 2 month ostarine cycle at 25mg. Did blood work and inbody measurement. Dropped 3% bodyfat while eating about 250 more calories a day then usual and gained 10lbs of muscle according inbody BIA. No major changes in blood work.
I’m I’m sure 250mg test for 12 weeks would double those results. Just can’t get over the complications with injecting.
Anyways to back track, I really appreciate the info guys!
My pleasure and thanks for coming back to the thread and saying thank you. Best wishes and to your health!
