I have a doubt with the half life of cypionate, really with de half-life in general … Someone can explain me??
For example if you inject 250 mg of cypionate testosterone for month , how the body assimilattes??. I was lookin for the information but i can´t understand.
For example if the half life is 12 days, day 12 i´ll have 125?? and the day 24 i´ll have 62,5… ufff sorry i think i´m complicating myself jaja
I don’t know half life means… because my doctor tells that cypionate can put once every 4 weeks but i know this is not good, but i don’t understand how cipionate works…
Everyone metabolizes testosterone at a different rate, SHBG levels play a huge part. Any doctor suggesting injections once a month will see hormone levels lower than pre-TRT. It says your doctor doesn’t do TRT very often, if he did he would have learned by now that injections once a month let alone once every 2 weeks would have seen patients coming in and complaining of low T symptoms long before the next injection.
This doctor is basing everything off theory and zero experience.
Wow, your spelling/typing is terrible. My doc put me on cyp 100 mg once a month, which was even worse than what you were prescribed. I think you do have a generally correct vague understanding of how half life works. You will want to find a doc that is willing to at least let you do once a week injections, maybe more often depending on SHBG. Good luck!
I told doc if i could divide dosage for 4, But he tells that de half life covers the whole month. It’s my obsession with half life :))
i read that with high shbg is more complicated, but i only want to speak with doc that 250mg once for month is a bad idea
But someone could explain me how half-life works with 250mg of cypionate???
my T level are low 210
shbg is high 68,70
T free is low 2’50
the rest are in range. thyroid too
I have 32 years old and no sex drive and fatigue.
Thanks for reply my and if someone can explain me a bit i’m very thankfull
I saw 2 docs and one tells me 250 mg and other 100 mg once a month and in two month reevaluate.
Thanks for all!!!
TRT isn’t outdated in your country, the doctors are just not educated in TRT. If you do the math a man will be below 300 ng/dL after about 2-3 weeks. The object of TRT is to maintain stable levels with little fluctuations as possible.
Endocrinology seems to be the only field of medicine that never considers the half life of the hormone being injected. This is what happens when doctors have zero knowledge, so they start you out on 250mg once a month and after running tests right before your next injection 6 weeks later they find your levels at the bottom of the ranges.
So they now know once a month injections doesn’t work, this is how doctors learn, not from the guidelines, but from actual experience and your doctors have none. The guidelines and instructions on the T-cyp are utterly useless for a proper TRT protocol.
Hyper focusing on within ranges is a mistake and I believe it’s just lazy mindedness, symptoms must be considered as well, most doctors just triage people without considering if you have symptoms.
Show your doctor this study, it should end the discussion that once a month injections is a good idea. Look at what happens after only 6 days, testosterone drops dramatically below the optimal range. The 14 day mark, your right back in low testosterone land.
When I was injecting 200mg every 3 weeks, after only 5 days my energy plunged as if I fell off a cliff. My co-works would see it firsthand and ask me am I alright.
I would like to remind everyone that this study is over 12 year old!
??? I respectfully disagree with this statement. While there are always some endocrinologists/ doctors with a lack of experience in the field of TRT, it doesn’t mean they know nothing about it. Retaining all info learned from med school is hard, very hard, but usually they’ll still know more about hormones than you or me, because they’re doctors. If a doc is inexperienced in the field of TRT, then experience can help them fine tune their practices over time regardless. While 250mg once per month is a terrible protocal, I don’t think it’s the doctors fault for putting him on such a protocal, it’s what the guidelines state, therefore if one isn’t experienced in the field of TRT or other practice of medicine but needs to prescribe the guidelines can be a doctor’s best friend, as guidelines are typically very helpful, it’s the guidelines that need to be updated though, and I’m sure in 5-10 years from now we will have a new set of guidelines @systemlord
Hello jokem your english is fine I understand your question.
Here I hope this will help you understand the half life of T cyp.
[quote] Medication in system doubles when it reaches it’s steady state (5 half lives of that specific medication).
So if you took 100mg of test cyp/ week, the milligrams in your body would constantly be increasing until roughly 40 days go by. That means at 40 days, you will have 200mg in your system, not 100mg anymore.
If you don’t feel anything that great even after a few weeks on a specific dosage of testosterone, just be patient. Your total testosterone should constantly be increasing from day one until day 40.
With test cyp, only make dosage changes after 40 days of being on that specific dosage and frequency. This is why people always say it takes testosterone sometimes 3-6 weeks to “kick in”. It has to do with your receptors getting acclimated to these new testosterone levels, but it also has to do with the fact that maybe that 100mg in your system when you started didn’t really make you feel that great or raise your testosterone levels high enough, but after 40 days (5 weeks), you now have 200mg in your system and your total testosterone should now be doubled from when you first started, and this amount of milligrams in your system might be just what you needed to feel good and get your numbers where they should be. [/quote]
I hope this helps you on your path to understanding what we are talking about when halflife is discussed.
EDIT: additional reference info:
Testosterone Cyp (Half life 8 days) - Steady state in 40 days
Arimidex (Half life 2 days) - Steady state in 10 days
Aromasin (Half life 1 day) - Steady state in 5 days
HCG (Half life 2 days) - Steady state in 10 days.
Clomid ( Half life 6 days) - Steady state in 30 days.
thanks man!!! between your information and the explanation of hrdlvn i already resolve my doubt.
i think like yours, the meds are not educated in this. doctor can’t know all… but there isn’t the problem. the problem are the doctors which they don’t want hear pacients and discuss. ufff in sometimes it’s a bit exasperating…
thanks so much
I agree, but there’s nothing we can do about it, the only way to make a change is to work on the inside, publish data that shows without a doubt the flaws in 1x2-3-4week protocals and the benefits of more frequent (say 1xwk) injections and I intend to do exactly that later on in my life, so… Yeet
