Does T3 Increase Cortisol? TRT Not Working. Feeling Horrendous

Please don’t regret spending the time to post. I found the info very useful and plan to try some of the things you have figured out. Thank you.

work on getting bf % down , this could have affects that you wouldn’t think it does. im 6’1 240lbs 20% bf and need to drop 5% I know ill feel better and levels will be more favorable .

incline walk at 3.5mph on treadmill at 6-8% incline 40 mins a day is great

Dude, who told you magnesium slashes SHBG? If that was true many old people will fix their issues with magnesium…

How can I join this group, is it paid?

It doesn’t. The OP is uninformed and aggressively ignorant; a bad combination.

" As expected, magnesium sulfate administration induced a significant increase in serum magnesium levels (delta ) compared to placebo (delta ) (). Interestingly, total T levels remained substantially unchanged (delta ) in the intervention group while they were significantly decreased in the placebo group (delta ). The difference in total T levels between the 2 groups touched the statistical significance () (Figure 1). No differences were appreciated in bioavailable T (Bio-T), IGF-1, and SHBG concentrations."

He is right that in known studies, licorice has been shown to slightly reduce testosterone, but this is a moot point when administering exogenous testosterone.

The OP’s primary issues come from high cortisol levels which are resulting in high rt3 levels. If he’s able to reduce cortisol and rt3 he will feel significantly better. If t3 isn’t improving symptoms of high rt3, i.e. he’s still experiencing cold hands & feet etc AND he’s somehow validating that it’s increasing his cortisol levels, maybe T3 isn’t the solution.

But hey, keep knocking on a locked door. Seems like a smart idea. What do I know though.

Supplements proven to reduce cortisol or blood pressure:

Magnesium
DHEA
Fish Oil
Ashwaganda
Eurycoma Longifolia Jack
Ginkgo biloba

I have the studies on these too if you’d care to discuss them.

I also have not noticed a drop in SHBG provided I supplement magnesium. But I supplement only 150mg-300mg aspartate because with more I feel too sleepy the next day :frowning:

I can say from personal experience aswagandha makes me more relaxed(450mg per day) but have not measured cortisol since I started to take it

Do all those supplements listed reduce both cortisol and blood pressure? Or are some one or the other? I’ve had higher blood pressure readings with my doc so I’ve been trying to use some supps to help lower it. Have been using l-citrulline and magnesium for a while now and just started back up longjack. After reading your list I was hopeful that the longjack would help too when that wasn’t an intention with it.

All reduce cortisol with the exception of magnesium which lowers only blood pressure specifically. Another one to try for blood pressure reduction is vinpocetine.

Surprised no one here has mentioned phosphatidylserine…this is the go to supplement to reduce cortisol.

I was in the same situation as you, sky high cortisol, high RT3, high DHEA. First you need to start doing everything you can to lower cortisol. Lower stress, sleep, and have a consistent day/night cycle. You should take a dinural salivary cortisol test too. That will help tell us if you still have a dinural variation and lifestyle is causing these issues or if there is something else going on.

Thanks @Hostile. You a Beartooth fan? Just noticed your avatar was one of their album covers.

I like phosphatidylserine and have used it in the past but for me, I seem to build a tolerance to it quickly.

I am! Good band.

Scroll down to cortisol.

I was thinking about giving this to my 2 ADHD kids. They talk about soy derived type. Not sure what to do. Hate to mess with their development. They 13. They have issues learning

Any advice or knowledge on this @highpull @unreal24278

What are we talking about giving you’re children?

I have ADHD, I take dexamphetamine… I fucking hate it… But it works wonders regarding focus and concentration

Talking about phosphatidylserine

Soy based? Or sunflower lecithin? Any recommendations. Should I even?

@unreal24278

There does appear to be minor cognitive enhancement and reduction of symptoms associated with ADHD with supplementation of Phosphatidylserine. However I’m no expert on the substance, nor do I know the mechanism as to behind how it works (though I could research it a bit if ya want). I’ve heard of it before as nootropics/drugs/medicine in general fascinates me.

One study shows it blunts exercise induced increase in cortisol and has no effect on T

Either way I’m not particularly comfortable giving drug advice to anyone, esp 13 y/Olds. I don’t have much experience or knowledge regarding Phosphatidylserine.

Yes. Please. @unreal24278

Also if Soy based? Or sunflower lecithin? Is better/safer

I started drinking coffee at 12. It’s a form of self-medication among many ADD/ADHD people (I was not aware that I had ADD at the time, I was never hyperactive). Do they lift? That does more for me than any other thing I have tried so far, and it has only minor sides that I can live with ; )

I have heard of this but have little real experience with it. I do know someone who specializes in treating kids with ADHD and uses a lot of diet and supplements. I’ll see what I can find out.