You know that simply isn’t always the answer, atleast not for everyone. Can you also answer my previous post in where I ask why would it really matter where the aromatase is blocked considering there will be a supply of E2 in the blood?
Have you guys seen Everything Mainstream Medicine Gets Wrong About the Side Effects of Hormone Optimization?
Just watched it. Thanks for sharing. Funny how the presenter talks about the dangers of extrapolation then proceeds at the end to talk about running women to 300 ng/dl mean TT and they feel good. So what’s the problem? Guess we will find out if there is a problem once we have long term data.
Notice this paper wasnt mentioned either…
Conclusions
Our data and others support an association between hyperandrogenism and mild elevations in blood pressure, endothelial dysfunction, and dyslipidemia in trans men and women with AE-PCOS. Despite the evidence that androgen exposure during gender-affirming hormone therapy is associated with mild hypertension, endothelial dysfunction, and dyslipidemia in trans men, the lack of long-term studies and infrequent follow-up measures for existing studies has led to uncertainty about the effects of HT on cardiovascular outcomes [80]. Cardiovascular markers are not always treated in trans men or AE-PCOS, leaving these cohorts at greater risk for cardiovascular events and future CAD, and even mild hypertension can be detrimental to the cardiovascular system when chronic. AE-PCOS is often diagnosed in the early teenage years, and gender transition often occurs at a young age. In both cases, androgen exposure will last for many years. Long-term and follow-up research are needed to develop guidelines for cardiovascular outcomes during HT and support health and longevity in trans men.
Paper he mentions at the end:
https://www.maturitas.org/article/S0378-5122(12)00373-8/fulltext
Also, great that he clarified PV vs erythrocytosis but then missed a great opportunity to discuss what drives blood viscosity…two major components (Hct and plasma viscosity). So there is no such thing as thick blood? Hmmm.
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As someone who gets phlebotomies every month, just got back from one today, I would like to see this study of the mice with 83% hematocrit and no circulatory problems.
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@enackers ???
Watch this video here guys. Doctor Nichols clearly explains this .
You can watch the video above. Doesn’t matter what’s said. Most won’t even acknowledge what he’s saying out of fear…
He has many patients over a long time line and not one has had issues with blood due to trt.
I personally don’t give blood and my hematocrit had increased several points 
.
I have zero symptoms of PCV. I feel great.
I am asking you what does it matter where the AI works as long as you don’t crash E2 and it circulates to all the tissues….
Also “me me me me me”
Brother you do not know for a fact where it’s being blocked. You do not know.
I sound like a broken record.
When one realizes how vital E is to our health, you would shy and run away from AI usage.
It simply isn’t an option.
Trt folks confuse PCV polycythemavera or however it’s spelled.
Literally exact same thing happens to men on trt that happens to men who live at high altitude.
This isn’t a blood cancer or disease that’s going to make the blood thick …
The video explains it all.
Dr Keith has many patients and backed by Rouzier. Not once have we seen their patients sue them or come to these forums because someone had died from thick blood.
By now it would of happened.
It’s been a very long time and thousands of examples …
You don’t pay attention to anything I’ve said man.
You know I’ve clarifird that E is vital for the health of everything from libido found in the brain, bone health, endothelial lining , cardio vascular and so much more.
Why would you want these areas to be effected by an AI. What if you are getting less estrogen to your bones or heart than it needs.
Honestly I don’t give a shit what you do. I’m just explaining what and why, but you refuse to understand.
How does somebody discuss a topic with you, when you don’t even read what’s being said?
Once again……. What does it matter where the conversion is blocked??? It’s not a SERM.
Me me me me me me me
By asking this question you don’t understand how testosterone and it’s active metabolites work. I suggest you watch the video. Estradiol does not act as an endocrine hormone in males, it acts as a paracrine hormone. Testosterone reaches the target tissues and is converted into it’s active metabolites in the tissues. What you are measuring in the serum wit regard to estradiol is what is produced peripherally mainly by the adipocytes and it does not have an endocrine effect. When you take an aromatase inhibitor you block the conversion of testosterone to estradiol everywhere therefore you lose the beneficial effects of testosterone at the tissue level. Your thought process is that since estradiol is circulating through the blood it will then enter the tissues and exert its effects but that’s not how estradiol works. I suggest you watch the video before responding and maybe learn something in the process
Lol all you groupies with your usual sources and the same talking points that don’t have much substance. Watch the video you say? Is what they are saying clinical proven and shown in practice?
Some people like yourself refuse to learn don’t you? There’s not a single guideline on testosterone therapy that recommends measuring and controlling estradiol. Not one, not one in the USA or not one in the European countries. The reason you do it isn’t because the medical literature does it. You do it because it’s the way you learn from forums and other non-evidence based medicine sources such as the bodybuilders etc. You refuse to acknowledge that all the studies showing benefits of testosterone in men didn’t block estradiol.
You also refused to even learn how testosterone actually works in the various tissues. It works through it’s active metabolites DHT and estradiol. Testosterone primarily acts as testosterone in muscle tissues. When are you take an aromatase inhibitor you actually block the beneficial effects of testosterone in the tissues where it is needed. What you are measuring in the serum is not what’s actually at the tissue level. So let’s think about this why don’t you or anyone else provide us with a study that gave testosterone to men and blocked estradiol and there was benefit. Just give us one.
How about I provide you with every study ever done with testosterones that showed benefits as a counter argument. You can’t provide one single article to support what you do. Even mainstream medicine knows better than to block estradiol in men on testosterone therapy and the most recent guidelines which were co-written by Dr. Abraham Morgenthaler specifically states do not block estradiol and don’t use non-aromatizable androgens for testosterone therapy. It is clinically proven that testosterone therapy exerts its beneficial effects through its active metabolites and when you block those active metabolites you will cause harm just like what we’re seeing with the five alpha reductase inhibitors and then aromatase inhibitors. It’s OK to continue to follow bodybuilding science and ignore actual medical science. It’s perfectly OK to do that if you like
No glass test tubes or lab viscometers here…
https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP280141
Enjoy.
More in my hematocrit thread. No coverage of this study in the podcast.
I already watched it and the other one talking about hematocrit (everything mainstream medicine got wrong about hormone optimization) after Jay Campbell replied to my post about phlebotomies every month.
It’s going to take time for mainstream medicine to do a 180 on some things related to sex hormones.
My second Kaiser endo told me high hematocrit and hemoglobin on TRT is of no consequence, sadly he retired.
Show evidence in where it shows circulating estrogen is not up taken by tissue and the main supply of E2 to tissue is through T uptake first.