Nah, it’s bullshit. It’s not only used in HIV patients. But anyways, my topic is about Boldenone. You’re a very active member here, right? In your opinion what kind of steroids can I run for my goals besides it?
I was giving an example. Nandrolone is occasionally used for postmenopausal osteoporosis, anaemia associated with chronic renal failure, aplastic anaemia and is typically not considered a “first line” drug/is used in conjunction with other therapies. The drug is occasionally scripted off label for “joint pain”, typically in conjunction with testosterone.
I don’t feel comfortable giving out this type of advice.
You always give advices in this forum, specially in pharma topics LMAO
You just had to say “I don’t know” because I think many here don’t too. Somethig in comum in internet is that everyone is egocentryc acting like the smart ones when in reality are all npcs agrouped.
Oh, whatever…
I’ve occasionally given advice regarding tactics to reduce harm associated with PED use. Giving advice under the guise of “these are the drugs you should use” isn’t something I’d do as I am not qualified to do so. This has nothing to do with me having too much of an “ego” to reply.
You shouldn’t come on here expecting to be spoon fed advice. If I’m being honest you come across as undiplomatic and set in your ways.
You claim high estradiol is the culprit of perceived neuropsychiatric abberations, yet you are bipolar and admit you have a pre-existing penchant for excess anxiety/aggression.
All anabolic steroids interfere with neurotransmission. Some have a higher penchant for inducing neuropsychiatric disturbances. Boldenone/19-nors appear have gained the most notoriety regarding impacts on mental health.
I’m not giving advice, but if you don’t want to be using aromatizing androgens as you believe estrogen is culpable for mood alteration… Perhaps look into non-aromatizing androgens. I’ll even list out the most commonly used non-aromatizing AAS used
Methenolone
Drostanolone
Oxandrolone (c-17aa)
Stanozolol (c-17aa)
Chlorodehydromethyltestosterone (c-17aa)
Mesterolone
Trenbolone
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As an organic chemist, I can say that the structure of boldenone is not a favorable one for aromatization of the 1st ring. Its quinone-like properties and the methyl at the C-10 position would inhibit easy aromatization. It would have to be demethylated and then oxidized into a phenol moiety, which is not thermodynamically favorable. This would explain the E2 crash.
Good to know there’s others out there who studied chemistry. You’re very welcome my friend.
True. That’s why I wrote:
So it acts as a quasi aromatase inhibitor in that way.
I actually don’t see quinone like properties as there’s no redox partner for the Keto at C3. Maybe you can help me there.
This is actually exactly what aromatase does with androgens. It oxidizes and then demethylates.
I agree. In this case the molecule is more stable than testosterone (or other 1-2 reduced androgens) making it possibly more difficult for aromatase to do its job.
And I agree with your perception. Aromatase does convert Boldenone in too low quantities to get E2 up enough. But my point, why I wrote all the above, was that more plates more dates theory is chemically unsubstantiated. If something happens it’s conversion to E2.
There’s also other reasonable hypothesis why E1 could be high.
Edit: just reread and realized how bitchy that came off haha. Wasn’t meant that way. Just clarifying. Feel free to give your opinion, I like the exchange of thought!
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Honestly, I didn’t see it as snarky or anything. I’ve been a long-time lurker on Pharma; I’ve never done any steroids, but I’ve been researching it for more than a year now to decide whether I want to dive in. You’re one of the ones I actually listen to.
Yes, it would be a damn good competitive inhibitor for test at the binding site on aromatase.
It’s not a true quinone, that’s why I used “quinone-like.” The 2 alkenes and the carbonyl “lock” the ring in that configuration, like a quinone. There is still resonance, where the 1-ene could shift and the carbonyl would form an alkoxide, with a + on C-2 {edit: I meant C-1}; this would help facilitate the elimination reaction that aromatase would perform after demethylation, which would have to occur first. (This could actually the crux of the issue: usually, after enolization, the demethylation and elimination are concerted, forming an aromatic ring. The fact that the enol cannot easily form, subsequently allowing this concerted step, could be the cause of the higher activation energy.) The resulting zwitterion would not be favored thermodynamically, which is why test aromatizes much more easily- there is no formally-charged intermediate.
So yes, it is possible, just unfavored. The activation energy is very high.
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Very nice! When I drew the reaction for myself that’s what I came up with. The elimination of the proton from an already positively charged carbon was the problem. That was the reason I had to skim study after study to see if there was one which found that the reaction happened. Because all the theoretical knowledge in the world sometimes doesn’t match nature’s ways. Aromatase is indeed an interesting enzyme.
For clarification: You mean a 
on C-1 right?
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It would be nice if the theoretical turned out to be true just a little more often, but oh well. And yes you are correct, it’s C-1. Thanks for catching that. I should have been looking at the structure when I was typing.
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I don’t recommend taking boldenone. It has various side effects, especially for men. Some studies show boldenone has significantly harmed males’ reproductive system. Besides, it led to a decreased size of the testes and lower sperm mobility. I would suggest trying sedative pills if you suffer from anxiety. My husband orders them from aptekastore.com. He suffers from anxiety and panic attacks. When taking the pills, he doesn’t have difficulty concentrating and doesn’t get easily irritated. Boldenone may not only worsen your anxiety but cause unpredictable side effects.
You realize this is two years old?
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I dont suggest you ever drive a car then. Statistically, that is the most dangerous activity on the planet.
And this, yea.
I laughed at this one but refrained from comment.
Yes as do all steroids. This is a pharma forum. IMO it happens to be no greater than the middle of the spectrum of side effect profiles for anabolics. Its pretty tolerable to most.
Lost me on this one. As opposed to what… race horses? Women? Mystical creatures?
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You laugh but @BrickHead had a centaur as a child that died from AAS’s. That’s why he’s such a staunch supporter of remaining natty.
RIP Claude 
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Is this in reference to my mention of the centaur pose that is so popular amongst women on IG? @wanna_be
It is not. It was 100% just a joke and I had no idea there was any connection lol
I wanted the possible mythical creature owner to be well respected, above reproach kinda guy to really sell the story. Your name popped up in my mind.
Edit: just to make sure the joke is fully ruined Claude was the name of your supposed creature who died of bold poisoning
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It’s all good. 
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