http://www.sciencenews.org/view/feature/id/57132/title/Stomach’s_Sweet_Tooth
Summary: There are taste receptors in the gut, and artificial sweeteners stimulate them, with the response being more insulin production.
[quote]florin wrote:
http://www.sciencenews.org/view/feature/id/57132/title/Stomach’s_Sweet_Tooth
Summary: There are taste receptors in the gut, and artificial sweeteners stimulate them, with the response being more insulin production.[/quote]
So the real problem with soft drinks sweetened with sugar is the INSULIN RESPONSE and not the extra 100 calories they provide per serving?
Can you please show me a study where fasted subjects exhibit a significant insulin response when a reasonable amount of commonly available diet soda or equivalent is consumed in the absence of other food or calorie sources?
I’m with stronghold.
I refuse to believe that diet sodas are the enemy of fat loss. Overall health, perhaps. But, people that drink diet sodas that are fat, aren’t fat because of diet sodas.
Hypothetically, there may be a problem not in that there is significant insulin release in response to artificial sweetener, but that with habitual users the body has “learned” not to release insulin in response to detection of sweet taste whereas this ordinarily would be occurring.
It would become a problem then in that where real sugar is consumed, the body then does not release insulin in the same timing and amount as is the case after learning, from inappropriate responses to artificial sweetener, that in fact sweet taste does not necessarily mean glucose is coming in.
There is support for this hypothesis from at at least one rat study.
Whether it holds with humans, I don’t know.
HMnn yeah, I guess all those competitive bodybuilders who live on diet sodas during their contest preps must not have read that article -lol.
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[quote]florin wrote:
http://www.sciencenews.org/view/feature/id/57132/title/Stomach’s_Sweet_Tooth
Summary: There are taste receptors in the gut, and artificial sweeteners stimulate them, with the response being more insulin production.[/quote]
I don’t believe this sole study. I know plenty of diabetics who drink diet soda without an insulin response.
[quote]jsbrook wrote:
[quote]florin wrote:
http://www.sciencenews.org/view/feature/id/57132/title/Stomach’s_Sweet_Tooth
Summary: There are taste receptors in the gut, and artificial sweeteners stimulate them, with the response being more insulin production.[/quote]
I don’t believe this sole study. I know plenty of diabetics who drink diet soda without an insulin response. Skimming this, it doesn’t even seem to be a real study, where the insulin response of people was actually measured after drinking diet soda. Instead it’s just an observation (without eliminating any confounds) that some fat people drink a lot of soda. [/quote]
Dr.Scott Connelly was recently on Heavy Muscle Radio and he was asked a similar question about the receptors that recognize glucose as soon as you take a bite of something and send signals to begin insulin production. I believe it was John Romano who asked if sweeteners can fool the receptors. Connelly claimed that they only recognize glucose.
Well, there’s also the discussion of sugar alcohols, which, despite what some people may think, are pretty much ignored by the body because it gets confused, and really doesn’t know what to do with them (hence they keep going right on through!)
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[quote]The Mighty Stu wrote:
Well, there’s also the discussion of sugar alcohols, which, despite what some people may think, are pretty much ignored by the body because it gets confused, and really doesn’t know what to do with them (hence they keep going right on through!)
S[/quote]
This reminds me of a time when I was dieting pretty hard, and I went out to the movies with some friends. I like to have something sweet at the movies, so I had a bunch of this “sugar free” candy that was sweetened with sugar alcohols. I had to skip going out for the post-movie dinner because it gave me some of the worst shits of my life. My gut was churning like a cement mixer.
[quote]The Mighty Stu wrote:
Well, there’s also the discussion of sugar alcohols, which, despite what some people may think, are pretty much ignored by the body because it gets confused, and really doesn’t know what to do with them (hence they keep going right on through!)
S[/quote]
And then you start farting 
I didn’t read the study because the page won’t load (can anybody tell me the author names?); however, artificial sweeteners cause release of hormones that potentiate insulin secretion. Whether these hormones stimulate insulin release in this situation, I’m not sure. Also, sweeteners increase expression of glucose transporters in the intestinal epithelial cells. To my limited knowledge, these are the two ways they would elicit an insulin response.
The finding that obese/overweight consume higher amounts of diet soda than lean people, I think, is a cause of obese/overweight attempting to lose weight by drinking diet soda as others have said.
Hah yea I’m not sure what is going on here; the writer/hypothesizer appears to lack some knowledge. Someone is not interpreting this correctly.
GLP-1 causes glucose-dependent insulin secretion, hence if the diet soda has no glucose in it, then the GLP-1 release induced by the diet soda will not cause ANY insulin secretion.
GLP-1 only causes insulin release from the Beta cell when the Beta cell is detecting a certain level of glucose from the bloodstream; it has a specific mechanism to accomplish this. The GLP-1 released can have other physiological effects which are for the most part desirable, look up the physiology of GLP-1 - it does a lot.
If you are eating food on top of the diet soda then maybe you could argue there is a bit more insulin released, but since you are already eating, you are going to release GLP-1 from the solid food anyways and the glucose in the solid food will permit the GLP-1 to induce insulin secretion (along with its other physiological functions).
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15069-74.
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM.
National Institute on Aging/National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
Abstract
Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protein gustducin, and several other taste transduction elements.
Mouse intestinal L cells also express alpha-gustducin. Ingestion of glucose by alpha-gustducin null mice revealed deficiencies in secretion of GLP-1 and the regulation of plasma insulin and glucose. Isolated small bowel and intestinal villi from alpha-gustducin null mice showed markedly defective GLP-1 secretion in response to glucose.
The human L cell line NCI-H716 expresses alpha-gustducin, taste receptors, and several other taste signaling elements. GLP-1 release from NCI-H716 cells was promoted by sugars and the noncaloric sweetener sucralose, and blocked by the sweet receptor antagonist lactisole or siRNA for alpha-gustducin.
We conclude that L cells of the gut “taste” glucose through the same mechanisms used by taste cells of the tongue. Modulating GLP-1 secretion in gut “taste cells” may provide an important treatment for obesity, diabetes and abnormal gut motility.
I had my dentist tell me that despite your body not being able to process the artificial sweeteners, bacteria can still utilize it. So unfortunately for us, diet soda still feeds all the little critters in your mouth which could be contributing to tooth decay. Now where did I put that diet mountain dew…
[quote]MODOK wrote:
Insulin is released in response to serum glucose concentration increase and not because something tastes sweet, right? If people got a spike of insulin each time they drank a diet coke while they are dieting or have a blood glucose of 80 or so, there would be a shitload of hypoglycemic people walking around…wouldn’t there?[/quote]
Bingo.
If diet soda caused any sort of insulin response in any sort of significant amounts, I would be dead right now.
I’m gonna go out on a limb and assume TNATOR is one of the guys Doc Connelly is sueing over that ProGenix nonsense -lol
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[quote]The Mighty Stu wrote:
Well, there’s also the discussion of sugar alcohols, which, despite what some people may think, are pretty much ignored by the body because it gets confused, and really doesn’t know what to do with them (hence they keep going right on through!)
S[/quote]
Really? I didn’t know. I was under the impression they had an effect close to sugar.