Can someone point me to or explain to me the DHEA, Test, Free Test, E2 relationship?
Thanks,
In the testes and other tissues: cholesterol → pregnenolone [done by mitochondria]
In the adrenals: pregnenolone → DHEA
In the testes: DHEA — … —> testosterone
In the testes and in peripheral tissues, aromatase performs T → E2
In the blood stream, T binds with SHBG and that is no long bio-available. About 2% of T remains as free T [FT]
Increased E2 causes the liver to make more SHBG and T+SHBG is removed by the liver.
Increased E2 reduces LH/FSH which reduces TT and FT levels.
In some males, DHEA is freely converted to E2, in other males, no noticeable effect like that.
Study this: Steroid hormone - Wikipedia
Which is also linked from the advice for new guys sticky which you should read.