My HDL (40) was unaffected on 120mg/week of Testosterone Cypianate. I added Nandrolone Decanoate, Oxandrolone, Anastrozole and Minoxidil.
I gradually increased up to 300mg/week of Testosterone, increased the Nandrolone from 100mg/week to 250mg/week, Oxandrolone sublingual at 40mg/day pre workout and 1mg Anastrozole 3/week.
After a few months I had a blood test and my HDL dropped from 40 down to 20 which was concerning.
I stopped the Nandrolone, Oxandralone and Minoxidil and lowered the Anastrozole and five weeks later a blood test showed my HDL back up at 40 which is normal for me.
Which compound(s) were most likely responsible for the huge drop in HDL? I want to add back the Nandrolone and Oxandrolone and keep the dosages of the Testosterone and Nandrolone as high as I can without lowering my HDL so much.
Agree with everyone else. The oxandrolone did the most damage. Anastrozole will likely impact HDL, but much less than oxandrolone (probably a tenth or less of an impact).
All of em.
My LDL is always normal, but my HDL has been barelly existant no matter what i take, so i dont even bother with it. I take my statins, i take my omegas and lecithin, i do my cardio, and i just hope for the best because my HDL is almost the same low on 3 grams of gear total as it is on just trt-cruise dose of test.
Nope. Anavar is “mild” which means you either take low dose and dont get any benefits or take large dose and get benefits and sides.
Stuff like tren is “harsh” which means benefits and sides at low dose and more benefits with more sides at higher dose, haha. At the end, everything that yields any benefit, also gives sides.
Consider changing only one variable at a time. You need to run a “design of experiments” meaning: use the information you have for yourself and known bro science to run a series of experiments to see which variable(s) effect HDL.
Assuming the oxandrolone is the main culprit, run X weeks of T at 120 mg/week (since you have data showing this doesn’t effect HDL for you) and oxandrolone 40mg/day. Take nothing else and then test to see what changes.
The next experiment will be based on that result. So if nothing changes, increase T to XXX mg/week and hold oxandrolone constant at 40 mg/day.
And so on. Takes time, but you seem to care about your general health so it’s seem worth the effort.
I reapectfully disagree on this topic. Its the Anavar. Take it at any dose, and your HDL will decrease and your LDL will increase. No experimentation needed.
Sometimes we fool oursleves to hope beyond hipe that we can crack some magic code that will allow us to avoid the negative side effects.
Yes, there are side effect generalities that can be assumed for any person. But it’s not about avoiding the side effects completely. That’s wishful thinking. It’s about managing the level to which I am comfortable.
I was on oxandrolone 25mg/day for 3 months. Went off for 2 weeks then blood test. Yeah, pretty small dose, but zero change in my lipids from prior blood test with no oxandrolone. But I thought my lipids were supposed to change for the worse?
I won’t know my limit unless I experiment with higher doses.
What were your lipids ON oxandrolone (mid-cycle)? This is the point. Not two weeks after stopping the drug. We all (hopefully) return to normal after cycling…
The timing of my last blood test and stopping oxandrolone didn’t align.
I’m not anywhere close to an expert on any of this stuff, but it seems unlikely my lipids would return to normal in only two weeks if they were way out of whack. But maybe my lipids recover faster than I realize.
I’m going to be on oxandrolone for my next blood test to see the impact.
IME when I run Var, at any dose, it takes about 1 week for it to impact my blood work and it takes 2 weeks for me to recover. SHGB, lipids, eGFR all are back to normal at the end of week 2. That doesn’t mean it didn’t impact those markers while I was on it tho.
All AAS will impact HDL to some degree, but as others have said, it was the Var. Anavar being bro-moted as the “safest” is not true. It wrecks lipids. Adex will to a lesser degree, and it was in there too, so…
Consider looking into 500 mg of citrus bergamot am and pm.
Thank you. I have been taking citrus bergamot three times a day along with Ubiqunol the same three times per day. I have also been taking Flush Niacin 125mg four times a day as I heard it is supposed to also help with raising HDL. The dosage of flush Niacin I am taking is lower than what I have heard to take but usually taking more brings on the heat and itching sensation.
Just an FYI, you use a “design of experiments” so you don’t have to change one variable at a time. It is a method used to minimize the amount of tests you need to run to understand impacts on a characteristic from several variables (each trial will vary more than one variable).
What you are suggesting is called an OFAT study (one factor at a time). I would do this (and it seems you agree). I would highly suggest not running a DOE (design of experiments) here. They are tough to get right, and I wouldn’t play with my body like that haha.
FWIW, I have only run 2 or 3 DOEs, and all failed. It is tough getting the variables you think matter identified, as well, it’s tough to have the settings right to get a meaningful response.
