There is nothing wrong with anastrozole. It is your body that is different some how. We have seen many needing 1/4th expected dose and a couple needing 1/t8th expected dose. In some cases low dose aromasin is a viable alternative. There is no way to know who will face these challenges in advance. I hope that you are on the path to getting this resolved.
Felt great for 3 weeks on new protocol which is curently:
50mg Test cyp every 3 days.
250 IU Hcg 3 Times a week.
I felt off this week. Anxious, meh erection. Drew labs to see what direction I am trending.
Drew labs the afternoon after Injected 50mg sub Q. So this is not a trough drawing.
Labs:
Total test 772 ng/dL (300-1080)
SHBG: 28.6 (16-55)
Free calc: 189.8 pg/mL (47-244)
E2 : < 17 pg/mL non estrogen sensitive (<60pg/mL)
Problems:
Despite no dex or DIM and more frequent injections my E2 continues to run low. My total T has dropped from avg 1100-1250 over the last 2 years to 700’s.
Any protocol recommendations? I need my E 35-45 to feel good. I took a previous commenters recommendations and lowered my total dose. Predictably my E went lower too which was not my goal. I need E higher.
Think my new protocol had to many chances.
Dropped total dose, more frequent injections, spilt my HCG from twice a week to 3 times a week. These are all strategies used to control high E not raise E which is what I need.
Or is the every 3 day injection frequency even the right path for me. I took your precautions to heart and dropped to 150/3 with less than adequate results.
I must be one of the few who completely lose E2 control injecting EOD no matter the dosage, damn I special. Most find success injecting smaller doses if SHBG is low enough, otherwise no.
If your having issues with low E2 injecting more frequently is going in the wrong direction! You want more E2 inject larger dosages less frequent. Raise T dose to increase E2, drop the AI for awhile and inject 50-60mg twice weekly to start.
If E2 is always low you shouldn’t even be on an AI at all. Keep increasing T dosage until E2 is where you like it. Make changes every 6 weeks, gauge how you feel, then run labs and decide if you’re happy with results. If not increase dosage a little more and back off if you go too far.
Yes I’ve kicked AI for 2 months. Had my E 25ish and still felt meh. I thought increasing T frequency would lead to consistently higher T levels with E to follow and stay higher. Tried micro dosing with no success. Plan is to increased T dose.
This recent change was 50mg every 3 days 150/week.
If you’re having trouble aromatizing with the T injections, could you not experiment with small increases in HCG to see if it can raise your estrogen through direct conversion in the testicles?
Yes that would be an option. My last change I split my hcg from 375iu twice weekly to 250iu 3 times per week following my increase in test frequency. I was doing HCG the day before my T injection.
My options as I see them:
1 - stay three times per week but up total T back to 200. 66/66/66. Can tweak hcg back to twice weekly total 750 or keep 3 times.
2- go back to 200/week injecting 100/100. Can switch hcg back to 750 total spot 375/375
Oh yeah I’ve updated on my running thread. I’ve been off of anstrazole for 11 months now.
I switched to 50mg Test cyp SQ eod in maybe April/May and I’ve never been better honestly.
In June/July I started throttling my doses. Moving between 45-60mg eod with fabulous results. I’ve finally after nearly 3 yrs on trt found what works for me.